The effect of tobacco additives on smoking initiation and maintenance

Variations in TAS1R taste receptor gene family modify food intake and gastric cancer risk in a Korean population

“…The alteration at this locus was relevant to the consumption of sweets and tobacco cigarettes. Tobacco smoking elevated the risk for GC and cigarettes contain a massive number of chemical molecules, including over 600 additives . The altered taste intensity associated with variant T1R1 may change the perception of the molecules in a cigarette, possibly leading those with the CC genotype to dislike the taste of tobacco and hence to reduced tobacco consumption.…”

O impacto dos aditivos do tabaco na toxicidade da fumaça do cigarro: uma avaliação crítica dos estudos patrocinados pela indústria do fumo

“…The relationship between effect (an increase in biomarker) and exposure is also poorly understood" 47 . As aforementioned, Anvisa's expert working group on tobacco additives also concluded that available scientific evidence (as to August 2014) was insufficient to support any conclusion that additives have no impact on tobacco smoke harmfulness 7,17 .…”

“…Tobacco company documents and reports disclosed by litigation (The Legacy Tobacco Documents Library, LTDL; https://industrydocuments.library.ucsf.edu/tobacco/) strengthened public health scientists' suspicions that such a diversity of tobacco additives is incorporated into cigarettes to make them more attractive, palatable and desirable to potential consumers 2,3,5,6,7,8,9,10,11 . By doing so, tobacco additives would facilitate smoking initiation and maintenance thereby increasing prevalence of smoking and tobacco-related diseases in the population.…”

“…An international expert working group on tobacco additives nominated by the Brazilian Health Regulatory Agency (Anvisa) reviewed the scientific literature, and Brazilian Tobacco Industry Association (ABIFUMO) and agency reports and concluded that the toxicology data available for tobacco additives were insufficient to support companies' claims that they do not enhance tobacco smoke harmfulness 7,17 .…”

The taste of smoke: tobacco industry strategies to prevent the prohibition of additives in tobacco products in Brazil

“…One of the technologies used by the TI is the use of additives. The TI’s own internal documents point to additives as an important technology for expanding its markets 16 17 19 23–28. The use of additives in tobacco products facilitates tobacco use, enhances the effects of nicotine and allows the TI to use false claims of properties associated with health and well-being 27 29–32…”