Ausência de associação entre o índice de fragilidade e a sobrevivência de idosos no Brasil: Estudo FIBRA

Pereira, Alexandre Alves; Borim, Flávia Silva Arbex; Néri, Anita Liberalesso

doi:10.1590/0102-311x00194115

Cited by 8 publications

(8 citation statements)

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“…We identified in our sample, in which all individuals were living in a high social vulnerability context, that 33.4% of aged subjects investigated fulfilled criteria for physical frailty. A possible explanation for these differences may be related to the fact that in our study, most of the participants were in the 60 to 69 year old age group (53.3%; data not shown) and few participants were above 80 years old (13.5%; data not shown), while in a study carried out by Pereira et al [ 38 ] the age group ranging from 60 to 69 years old represented only 36.4% of the sample. More importantly, in the study by Pereira et al [ 38 ], the authors did not evaluate frailty using Fried’s score, but instead used the frailty index (FI), which probably contributed to the difference found in both studies, regarding frailty prevalence.…”

Section: Discussioncontrasting

confidence: 49%

“…A possible explanation for these differences may be related to the fact that in our study, most of the participants were in the 60 to 69 year old age group (53.3%; data not shown) and few participants were above 80 years old (13.5%; data not shown), while in a study carried out by Pereira et al [ 38 ] the age group ranging from 60 to 69 years old represented only 36.4% of the sample. More importantly, in the study by Pereira et al [ 38 ], the authors did not evaluate frailty using Fried’s score, but instead used the frailty index (FI), which probably contributed to the difference found in both studies, regarding frailty prevalence. Accordingly, Collard et al [ 39 ], in a systematic review of 21 studies ( n = 61,500), described that the prevalence of frailty in a community-dwelling population has a high variability, ranging from 4 to 59.1%.…”

Section: Discussioncontrasting

confidence: 49%

“…Frailty is a geriatric syndrome associated with disability and mortality outcomes in older people. In a recent multicenter, a population-based cross-sectional study showed a prevalence around 38% of frailty in Brazilian community-dwelling older people [ 38 ]. We identified in our sample, in which all individuals were living in a high social vulnerability context, that 33.4% of aged subjects investigated fulfilled criteria for physical frailty.…”

Section: Discussionmentioning

confidence: 99%

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Higher levels of tumor necrosis factor β are associated with frailty in socially vulnerable community-dwelling older adults

et al. 2018

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BackgroundThe complex physiology underpinning the frailty syndrome is responsible for the absence of robust biomarkers that can be used for screening, diagnostic and/or prognostic purposes and has made clinical implementation difficult. Considering socially vulnerable populations, who have poor health status and increased morbidity and mortality, this scenario is even more complex. However, to the best of our knowledge, there are no studies available to investigate frailty biomarkers in socially vulnerable populations. Thus, the aim of this cross-sectional study was to identify potential blood-based biomarkers of frailty in a socially vulnerable population.MethodsA sample consisting of 347 community-dwelling older people living in a context of high social vulnerability was divided into non-frail (robust), pre-frail and frail groups, according to modified Fried frailty phenotype criteria. Blood samples were collected and analyzed for basic metabolic parameters and for inflammatory cytokines.ResultsLevels of Interleukin-1α (IL-1α) and Tumor Necrosis Factor α (TNF-α) were significantly higher in pre-frail subjects, compared to non-frail ones. Tumor Necrosis Factor β (TNF-β) levels presented higher values in the frail compared to non-frail individuals. Interleukin-6 (IL-6) levels in pre-frail and frail subjects were significantly higher compared to the levels of non-frail subjects. Using an ordinal regression analysis, we observed that socially vulnerable older people at higher risk of developing frailty were subjects above 80 years old (OR: 2.5; 95% CI: 1.1–5.6) and who presented higher levels of TNF-β (≥0.81 pg/mL, OR: 2.53; 95% CI: 1.3–4.9).ConclusionAs vulnerable populations continue to age, it is imperative to have a greater understanding of the frailty condition, identifying novel potential blood-based biomarkers. The results presented here could help to implement preventive healthcare strategies by evaluating frailty and at the same time measuring a set of inflammatory biomarkers, paying special attention to TNF-β plasmatic levels.Electronic supplementary materialThe online version of this article (10.1186/s12877-018-0961-6) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

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Higher levels of tumor necrosis factor β are associated with frailty in socially vulnerable community-dwelling older adults

et al. 2018

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“…In two other large studies of the FIBRA Network, one conducted in Rio de Janeiro (RJ) with 737 elderly people 31 and another in Campinas (SP) with 900 32 , it was also found that approximately 70% and 76.5% of elderly, respectively, exceeded the MMSE cutoff point. Thus, it is clear that there is a certain similarity in the profile of elderly people in different regions of Brazil (North, Northeast, Midwest and Southeast), considering the MMSE score and other characteristics.…”

Section: Resultsmentioning

confidence: 93%

“…Em outros dois grandes estudos da Rede FIBRA, Fragilidade de Idosos Brasileiros (banco de dados de estudos realizados em várias cidades do Brasil sobre fragilidade de Idosos), um realizado no Rio de Janeiro (RJ) com 737 idosos 31 e outro em Campinas (SP) com 900 32 , também foi verificado que aproximadamente 70% e 76,5% dos idosos, respectivamente, superaram o ponto de corte do MEEM. Desta forma, percebe-se que existe uma certa similaridade no perfil de idosos nas diferentes regiões do Brasil (Norte, Nordeste Centro-Oeste e Sudeste), considerando a pontuação do MEEM e outras características.…”

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2019

Mundo Saúde

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The carrying out activities of daily life and falls are factors directly related to quality of life, which can influence the independence and autonomy of elderly people. The objective of the study was to evaluate activities of daily living, risk and fear of falling in elderly people in Campo Grande, MS. This was a cross-sectional study, carried out with 32 elderly men and women, age ≥60 years and were participants in the Open University for the Elderly program, from April to September 2018. A Mini-Mental State Examination score ≥19 points was considered as the inclusion criterion. Instruments used were: Sociodemographic questionnaire; Katz index; Lawton-Brody scale; Downton scale that assesses the risk of falling and the Falls Efficacy Scale-International (FES-I-BRASIL) which assesses the fear of falling. According to the Katz Index, most elderly people were independent (84.4%). The Lawton-Brody Scale classified the majority of the elderly participants as independent (53.1%) and partially dependent (46.9%). On the Downton scale, the age group from 70 to 82 years old reached a score of (3.6±1.5) demonstrating a high risk of falling, at FES-I-BRASIL female elderly reached (25.6±6.6) points, showing a greater fear of falling. There was a relationship between the FES-I-BRASIL and Lawton-Brody scales (r=-0.443/ p=0.011), that is, the more thy carrying out crucial activities of daily living, the lower their concern is with falling. Elderly people in a more advanced age group have a higher risk of falling and female participants were more concerned about falling than their male peers.

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A multidimensional approach to frailty compared with physical phenotype in older Brazilian adults: data from the FIBRA-BR study

et al. 2021

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Background Frailty is a predictor of negative health outcomes in older adults. The physical frailty phenotype is an often used form for its operationalization. Some authors have pointed out limitations regarding the unidimensionality of the physical phenotype, introducing other dimensions in the approach to frailty. This study aimed to create a multidimensional model to evaluate frailty in older Brazilian adults and to compare the dimensions of the model created among the categories of the physical frailty phenotype. Methods A cross-sectional study was conducted using data from 3569 participants (73.7 ± 6.6 years) from a multicenter and multidisciplinary survey (FIBRA-BR). A three-dimensional model was developed: physical dimension (poor self-rated health, vision impairment, hearing impairment, urinary incontinence, fecal incontinence, and sleeping disorder), social dimension (living alone, not having someone who could help when needed, not visiting others, and not receiving visitors), and psychological dimension (depressive symptoms, concern about falls, feelings of sadness, and memory problems). The five criteria of the phenotype created by Fried and colleagues were used to evaluate the physical frailty phenotype. The proposed multidimensional frailty model was analyzed using factorial analysis. Pearson’s chi-square test was used to analyze the associations between each variable of the multidimensional frailty model and the physical phenotype categories. Analysis of variance compared the multidimensional dimensions scores among the three categories of the physical frailty phenotype. Results The factorial analysis confirmed a model with three factors, composed of 12 variables, which explained 38.6% of the variability of the model data. The self-rated health variable was transferred to the psychological dimension and living alone variable to the physical dimension. The vision impairment and hearing impairment variables were dropped from the physical dimension. The variables significantly associated with the physical phenotype were self-rated health, urinary incontinence, visiting others, receiving visitors, depressive symptoms, concern about falls, feelings of sadness, and memory problems. A statistically significant difference in mean scores for physical, social, and psychological dimensions among three physical phenotype categories was observed (p < 0.001). Conclusions These results confirm the applicability of our frailty model and suggest the need for a multidimensional approach to providing appropriate and comprehensive care for older adults.

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Ausência de associação entre o índice de fragilidade e a sobrevivência de idosos no Brasil: Estudo FIBRA

Cited by 8 publications

References 43 publications

Higher levels of tumor necrosis factor β are associated with frailty in socially vulnerable community-dwelling older adults

Higher levels of tumor necrosis factor β are associated with frailty in socially vulnerable community-dwelling older adults

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A multidimensional approach to frailty compared with physical phenotype in older Brazilian adults: data from the FIBRA-BR study

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