La traduccion del conocimiento en cancer cervicouterino: una brecha entre la investigacion sobre las causas y la investigacion sobre la atencion al paciente?

Fajardo-Ortiz, David; Ochoa, Héctor; Garcı́a, Luis; Castaño, V. M.

doi:10.1590/0102-311x00168512

Cited by 6 publications

(9 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, there are not clearly defined frontiers dividing the research fronts. However, the standard in the scientometrics study of research fronts seems to be to use clustering methods that define frontiers between the modules [14, 17, 18, 24, 25, 27, 28], probably because this is make much more understandable the community structure in a literature network. Moreover, our analysis reveals the front that is most relevant to each paper.…”

Section: Discussionmentioning

confidence: 99%

“…There are some studies that focused in the structure of the biomedical knowledge on specific diseases [14, 16, 17, 27, 28]. Our previous research has been particularly focused in the core region of the literature networks [14, 17, 27]. By doing this we have discovered the key feature of the organization of the knowledge on cervical cancer [27] and Ebola fever [17].…”

Section: Introductionmentioning

confidence: 99%

“…Our previous research has been particularly focused in the core region of the literature networks [14, 17, 27]. By doing this we have discovered the key feature of the organization of the knowledge on cervical cancer [27] and Ebola fever [17]. Others have reported the evolution of research fronts in anthrax research [16], cancer research [28] and cardiovascular medicine [28].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The emergence and evolution of the research fronts in HIV/AIDS research

et al. 2017

Self Cite

View full text Add to dashboard Cite

In this paper, we have identified and analyzed the emergence, structure and dynamics of the paradigmatic research fronts that established the fundamentals of the biomedical knowledge on HIV/AIDS. A search of papers with the identifiers "HIV/AIDS", "Human Immunodeficiency Virus", “HIV-1” and "Acquired Immunodeficiency Syndrome" in the Web of Science (Thomson Reuters), was carried out. A citation network of those papers was constructed. Then, a sub-network of the papers with the highest number of inter-citations (with a minimal in-degree of 28) was selected to perform a combination of network clustering and text mining to identify the paradigmatic research fronts and analyze their dynamics. Thirteen research fronts were identified in this sub-network. The biggest and oldest front is related to the clinical knowledge on the disease in the patient. Nine of the fronts are related to the study of specific molecular structures and mechanisms and two of these fronts are related to the development of drugs. The rest of the fronts are related to the study of the disease at the cellular level. Interestingly, the emergence of these fronts occurred in successive "waves" over the time which suggest a transition in the paradigmatic focus. The emergence and evolution of the biomedical fronts in HIV/AIDS research is explained not just by the partition of the problem in elements and interactions leading to increasingly specialized communities, but also by changes in the technological context of this health problem and the dramatic changes in the epidemiological reality of HIV/AIDS that occurred between 1993 and 1995.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The emergence and evolution of the research fronts in HIV/AIDS research

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…This methodology could be useful for the development of an innovation roadmap for nanomedicine. This mapping strategy could inform about which research groups, ideas or approaches are effectively connecting the basic research with the clinical observation [16,7]. Moreover, we have shown, in a previous research, how this methodology could provide accurate information about the current status of development of a nanomedicine research.…”

Section: Introductionmentioning

confidence: 96%

“…The journals inter-citations are then analyzed [20,21]. Finally, we have developed an innovative methodology [16,17] which combines semantic analysis with network analysis to identify hidden colleges and/or stages of the innovation process. This methodology is based on the semantic analysis performed by GOPUMED [22], which is based in controlled vocabularies (Medical Subject Heading [23] and Gene Ontology [24]).…”

Section: Introductionmentioning

confidence: 99%

Mapping knowledge translation and innovation processes in Cancer Drug Development: the case of liposomal doxorubicin

et al. 2014

Self Cite

View full text Add to dashboard Cite

We explored how the knowledge translation and innovation processes are structured when theyresult in innovations, as in the case of liposomal doxorubicin research. In order to map the processes, a literature network analysis was made through Cytoscape and semantic analysis was performed by GOPubmed which is based in the controlled vocabularies MeSH (Medical Subject Headings) and GO (Gene Ontology). We found clusters related to different stages of the technological development (invention, innovation and imitation) and the knowledge translation process (preclinical, translational and clinical research), and we were able to map the historic emergence of Doxil as a paradigmatic nanodrug. This research could be a powerful methodological tool for decision-making and innovation management in drug delivery research.

show abstract

Hegemonic structure of basic, clinical and patented knowledge on Ebola research: a US army reductionist initiative

Fajardo-Ortiz

Ortega-Sánchez-de-Tagle

Castaño

2015

J Transl Med

Self Cite

View full text Add to dashboard Cite

BackgroundEbola hemorrhagic fever (Ebola) is still a highly lethal infectious disease long affecting mainly neglected populations in sub-Saharan Africa. Moreover, this disease is now considered a potential worldwide threat. In this paper, we present an approach to understand how the basic, clinical and patent knowledge on Ebola is organized and intercommunicated and what leading factor could be shaping the evolution of the knowledge translation process for this disease.MethodologyA combination of citation network analysis; analysis of Medical heading Subject (MeSH) and Gene Ontology (GO) terms, and quantitative content analysis for patents and scientific literature, aimed to map the organization of Ebola research was carried out.ResultsWe found six putative research fronts (i.e. clusters of high interconnected papers). Three research fronts are basic research on Ebola virus structural proteins: glycoprotein, VP40 and VP35, respectively. There is a fourth research front of basic research papers on pathogenesis, which is the organizing hub of Ebola research. A fifth research front is pre-clinical research focused on vaccines and glycoproteins. Finally, a clinical-epidemiology research front related to the disease outbreaks was identified. The network structure of patent families shows that the dominant design is the use of Ebola virus proteins as targets of vaccines and other immunological treatments. Therefore, patents network organization resembles the organization of the scientific literature. Specifically, the knowledge on Ebola would flow from higher (clinical-epidemiology) to intermediated (cellular-tissular pathogenesis) to lower (molecular interactions) levels of organization.ConclusionOur results suggest a strong reductionist approach for Ebola research probably influenced by the lethality of the disease. On the other hand, the ownership profile of the patent families network and the main researches relationship with the United State Army suggest a strong involvement of this military institution in Ebola research.

show abstract

La traduccion del conocimiento en cancer cervicouterino: una brecha entre la investigacion sobre las causas y la investigacion sobre la atencion al paciente?

Cited by 6 publications

References 22 publications

The emergence and evolution of the research fronts in HIV/AIDS research

The emergence and evolution of the research fronts in HIV/AIDS research

Mapping knowledge translation and innovation processes in Cancer Drug Development: the case of liposomal doxorubicin

Hegemonic structure of basic, clinical and patented knowledge on Ebola research: a US army reductionist initiative

Contact Info

Product

Resources

About