Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results

Braga, Cynthia; Albuquerque, Maria de Fátima Pessoa Militão de; Cordeiro, Marli Tenório; Castanha, Priscila M. S.; Ramesh, Anita; Alexander, Neal; Mello, Maria Júlia Gonçalves de; Marques, Ernesto T. A.; Martelli, Celina Maria Turchi

doi:10.1590/0102-311x00095815

Cited by 6 publications

(7 citation statements)

References 27 publications

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“…In fact, the proportion of losses was similar in other cohort studies in the same region (30.7%-35%) 29 . However, losses were smaller (14.7%) in a hospital-based infant dengue cohort study carried out in Recife, Pernambuco State 15 .…”

Section: Discussionmentioning

confidence: 90%

“…Most of the primary dengue cases occurred in children under 6-years-old 13,14 . In Brazil, a birth cohort study was carried out in Recife showing a cumulative incidence of dengue of 10% in infants in their first year of life 15 . Prospective studies including both passive and active serological surveillance are important to estimate the incidence of arbovirosis and to guide control measures.…”

Section: Introductionmentioning

confidence: 99%

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A populational-based birth cohort study in a low-income urban area in Rio de Janeiro, Brazil: implementation and description of the characteristics of the study

et al. 2019

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A comprehensive cohort study including an entomological surveillance component can contribute to our knowledge of clinical aspects and transmission patterns of arbovirosis. This article describes the implementation of a populational-based birth cohort study that included an entomological surveillance component, and its associated challenges in a low-income community of Rio de Janeiro, Brazil. The participants were recruited in two periods: from 2012 to 2014, and from 2015 to 2017. The children had scheduled pediatric consultations and in case of fever. Epidemiological, clinical data and biological samples were collected at pediatric visits. Active febrile surveillance was performed by telephone calls, social networking, message apps, and household visits. A total of 387 newborns and 332 new children were included during the first and second recruitment periods, respectively. By July 2017, there were 451 children on follow-up. During the study, 2,759 pediatric visits were performed: 1,783 asymptomatic and 976 febrile/rash consultations. The number of febrile or rash consultations increased 3.5-fold after the use of media tools for surveillance. No temporal pattern, seasonality or peak of febrile cases was observed during the study period. A total of 10,105 adult mosquitoes (including 3,523 Aedes spp. and 6,582 Culex quinquefasciatus) and 46,047 Aedes eggs were collected from households, schools, and key sites. Although challenging, this structured sentinel populational-based birth cohort is relevant to the knowledge of risks and awareness of emerging pathogens.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

A populational-based birth cohort study in a low-income urban area in Rio de Janeiro, Brazil: implementation and description of the characteristics of the study

et al. 2019

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“…This follow-up strategy was adopted to minimize loss to follow-up due to repeated venous punctures. The strategy allowed for the collection of clinical data and blood samples every 2 months in the first year and at two different points (months 18 and 24) in the second year [18]. Losses to follow-up in the cohort were attributable to refusal in participate of the study and by difficulties in tracing cohort participants due to incorrect and/or change of residence address.…”

Section: Methodsmentioning

confidence: 99%

“…The details of the study methodology were previously described [18]. Briefly, healthy pregnant women were enrolled at the time of admission for delivery.…”

Section: Methodsmentioning

confidence: 99%

“…In Brazil, despite the high transmission of the different DENV serotypes, dengue incidence and the risk factors associated with infection at early ages remains unknown. Therefore, we conducted a prospective birth cohort study in a large urban centre and hyperendemic dengue area in Northeast Brazil [18] to investigate the incidence of dengue infection and the kinetics of maternally transferred dengue antibodies among children in the first 2 years of life. We have previously described the high seroprevalence (∼90%) of DENV-specific antibodies among pregnant women enrolled at baseline [19], the efficient placental transfer of dengue antibodies to neonates and the kinetics of decay of these antibodies in this cohort [20].…”

Section: Introductionmentioning

confidence: 99%

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Incidence and risk factors for Dengue virus (DENV) infection in the first 2 years of life in a Brazilian prospective birth cohort

et al. 2017

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This study assessed the incidence and risk factors for dengue virus (DENV) infection among children in a prospective birth cohort conducted in the city of Recife, a hyperendemic dengue area in Northeast Brazil. Healthy pregnant women (n = 415) residing in Recife who agreed to have their children followed were enrolled. Children were followed during their first 24 months of age (May/2011-June/2014), before the 2015 Zika virus outbreak. DENV infection was detected by reverse-transcriptase polymerase chain reaction and/or serology (anti-DENV IgM/IgG). The incidence rates per 1000 person-years (py) and its association with risk factors by age bands (0-12, >12-30 months) were estimated through Poisson regression models. Forty-nine dengue infections were detected; none progressed to severe forms. The incidence rates were 107·6/1000py (95% CI 76·8-150·6) and 93·3/1000py (95% CI 56·1-154·4) in the first and second years of age, respectively. Male children (risk ratios (RR) = 2·33; 95% CI 1·09-4·98) and those born to DENV-naïve mothers (RR = 2·42; 95% CI 1·01-5·80) were at greater risk of infection in the first year of age. In the second year, children born to Caucasian/Asian descent skin colour mothers had a threefold higher risk of infection (RR = 3·34; 95% CI: 1·08-10·33). These data show the high exposure of children to DENV infection in our setting and highlight the role of biological factors in this population's susceptibility to infection.

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Dengue Virus and Other Flaviviruses (Zika): Biology, Pathogenesis, Epidemiology, and Vaccine Development

Alves

Ángel

2017

Human Virology in Latin America

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Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results

Cited by 6 publications

References 27 publications

A populational-based birth cohort study in a low-income urban area in Rio de Janeiro, Brazil: implementation and description of the characteristics of the study

A populational-based birth cohort study in a low-income urban area in Rio de Janeiro, Brazil: implementation and description of the characteristics of the study

Incidence and risk factors for Dengue virus (DENV) infection in the first 2 years of life in a Brazilian prospective birth cohort

Dengue Virus and Other Flaviviruses (Zika): Biology, Pathogenesis, Epidemiology, and Vaccine Development

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