2016
DOI: 10.1590/0102-311x00056715
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Abstract: O estrogênio sintético 17α-etinilestradiol, principal componente utilizado em formulações de contraceptivos orais, tem sido apontado como um dos principais compostos responsáveis por provocar efeitos adversos no sistema endócrino de várias espécies. O objetivo deste estudo foi analisar o estado da arte dos dispositivos legais e normativos referentes ao controle desse estrogênio sintético nas águas da Europa e dos Estados Unidos, e traçar um paralelo com a realidade brasileira. No geral, os países têm buscado a… Show more

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Cited by 30 publications
(16 citation statements)
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References 50 publications
(48 reference statements)
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“…According to some authors, chemical agents can act by multiple mechanisms, as well as blocking or disrupting agents of hormonal action, and may have not only cumulative but potentiated action in the development of organisms. 87 89 Some studies suggest that time of exposure is more important than the dose of exposure to these chemicals. It is still not possible to determine the likely mechanism of action of these agents.…”
Section: Discussionmentioning
confidence: 99%
“…According to some authors, chemical agents can act by multiple mechanisms, as well as blocking or disrupting agents of hormonal action, and may have not only cumulative but potentiated action in the development of organisms. 87 89 Some studies suggest that time of exposure is more important than the dose of exposure to these chemicals. It is still not possible to determine the likely mechanism of action of these agents.…”
Section: Discussionmentioning
confidence: 99%
“…The level of treatment to be adopted by the industry is associated with the legal release requirements and the desired quality standard of the treated effluent 24 . In relation to the Brazilian regulation regarding the launch of drugs in the environment, there is a need for its suitability, mainly due to new evidences of effects on wild biota and men 25,26 . However, the countries of the European Union already have standardization for the subject [27][28][29] .…”
Section: Introductionmentioning
confidence: 99%
“…Com o avanço da ciência e do conhecimento sobre os efeitos decorrentes da poluição dos corpos hídricos, alguns países da União Europeia e os Estados Unidos vêm buscando ampliar a regulamentação e o monitoramento de novos compostos, como os desreguladores endócrinos, que antes não eram objeto de atenção por parte dos dispositivos legais (Cunha et al, 2016).…”
Section: Introductionunclassified