2020
DOI: 10.1590/0101-60830000000241
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Abstract: Background: Previous studies have shown that major depressive disorder (MDD) is associated with a variety of cognitive deficits, which can persist even in remitted states. Nevertheless, the relationship between the cognitive and affective symptoms in depression remains obscure. The aim of the present study was to explore the clinical characteristics and correlates of the cognitive deficits in patients with MDD. Methods: Clinical and neuropsychological assessments were conducted at baseline and 6-month follow-u… Show more

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Cited by 11 publications
(9 citation statements)
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References 26 publications
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“…Neuropsychological results showed an improvement in several objective cognitive functions with a larger effect size in attention (d = -1.37) and processing speed (d = -1.18) and a lower effect size in working memory (d = -0.26) and executive function (-0.54). This nding is similar to the nding obtained in Ji et al's research [32], suggesting that they may function as important trait markers for MDD [33]. It can be said that there may be two fundamentally distinct cognitive dysfunctions in acute episodes of MDD, with executive functions possibly arising from cumulative effects of the duration of the illness (trait CI) and processing speed possibly arising from temporary effects of the common depressive episode (state CI) [33], which can explain this nding.…”
Section: Discussionsupporting
confidence: 93%
“…Neuropsychological results showed an improvement in several objective cognitive functions with a larger effect size in attention (d = -1.37) and processing speed (d = -1.18) and a lower effect size in working memory (d = -0.26) and executive function (-0.54). This nding is similar to the nding obtained in Ji et al's research [32], suggesting that they may function as important trait markers for MDD [33]. It can be said that there may be two fundamentally distinct cognitive dysfunctions in acute episodes of MDD, with executive functions possibly arising from cumulative effects of the duration of the illness (trait CI) and processing speed possibly arising from temporary effects of the common depressive episode (state CI) [33], which can explain this nding.…”
Section: Discussionsupporting
confidence: 93%
“…Several studies confirm that attention deficits are related to depression both in the acute phase of the illness ( 2 , 44 ) and in remission ( 51 , 79 , 80 ). Ji et al ( 72 ) found improvements in digit span in remission, that could indicate a relationship between MDD and attention. In addition, another study found an association between attention and inflammatory markers, which could partly explain state effects in attentional deficits.…”
Section: Resultsmentioning
confidence: 99%
“…Still, they conclude that remission, rather than numbers of previous episodes, has a high impact on cognitive performance in MDD patients, thereby supporting a state model. Other studies consistently find EF impaired in the depressed state (70,71), with some inconsistencies with regards to improvements with symptom reduction (54,72,73). Pu et al (46) found small correlations between an EF composite and depressive symptoms; however, this could vary by specific EF tasks measured (63).…”
Section: The Domain Of Executive Functioning (Ef)mentioning
confidence: 96%
“…The mental disturbance known as major depressive disorder (MDD) is characterized by the occurrence of frequent and severe emotional, cognitive, and somatic symptoms, and in most severe cases, it can result in suicide. According to the World Health Organization (WHO), MDD affects about 264 million people around the world . Also, according to a WHO’s projection, by 2030, this mental disorder will be the main cause of absence from work due to health issues, which causes a meaningful social and economic problem .…”
Section: Introductionmentioning
confidence: 99%