2017
DOI: 10.1590/0100-69912017005015
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Abstract: Pancreatic necrosis occurs in 15% of acute pancreatitis. The presence of infection is the most important factor in the evolution of pancreatitis. The diagnosis of infection is still challenging. Mortality in infected necrosis is 20%; in the presence of organic dysfunction, mortality reaches 60%. In the last three decades, there has been a real revolution in the treatment of infected pancreatic necrosis. However, the challenges persist and there are many unsolved questions: antibiotic treatment alone, tomograph… Show more

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Cited by 19 publications
(17 citation statements)
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“…The diagnosis of infected necrosis is an absolute indication for antibacterial drugs [86]. Despite the fact that the majority of patients with pancreatic infection require surgical intervention, the available clinical experience suggests that conservative treatment alone with carefully targeted antibacterial therapy will suffice in certain categories of patients [87][88][89][90][91][92]. The choice of antibiotic for infected necrosis is determined by the pathogenic bacterial agent and its sensitivity to antibiotics.…”
Section: Antibacterial and Antifungal Therapy In Patients With Infectmentioning
confidence: 99%
“…The diagnosis of infected necrosis is an absolute indication for antibacterial drugs [86]. Despite the fact that the majority of patients with pancreatic infection require surgical intervention, the available clinical experience suggests that conservative treatment alone with carefully targeted antibacterial therapy will suffice in certain categories of patients [87][88][89][90][91][92]. The choice of antibiotic for infected necrosis is determined by the pathogenic bacterial agent and its sensitivity to antibiotics.…”
Section: Antibacterial and Antifungal Therapy In Patients With Infectmentioning
confidence: 99%
“…Cytological examination by fi ne-needle aspiration was widely used in medicine, but nowadays its use is restricted and controversial. There are reports about secondary contamination that may occur in patients with pancreatic necrosis and the detection of the etiological agent becomes more diffi cult [8].…”
Section: Introductionmentioning
confidence: 99%
“…The mortality rate is influenced by the severity of the disease with several prognostic factors having been described. The presence of persistent organ failure is associated with the highest mortality, which is as high as 60% in some series 3. Gallstone pancreatitis is more common in women over the age of 60, especially among those with microlithiasis, while alcoholic pancreatitis is more frequent in males 4…”
Section: Epidemiologymentioning
confidence: 99%