Impact of Roux-en-Y gastric bypass on lipid and inflammatory profiles

Oliveira, Cleiton da Silva; Beserra, Bruna Teles Soares; Cunha, Rafael Xavier; Brito, Ana Gabriela Estevam; Miranda, Rafaella Cristina Dimbarre de; Zeni, Lucia; Nunes, Everson Araújo; Trindade, Erasmo Benício Santos de Moraes

doi:10.1590/0100-69912015005007

Cited by 6 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Both RYGB and LSG induced a drastic weight loss during the follow-up period, concomitantly with an improvement of glycemic parameters and insulin resistance, a decrease of triglyceride and an increase of HDL-cholesterol. A reduction of total and LDL-cholesterol was observed in the RYGB group but not in the LSG group, which is in agreement with previous studies [33,34]. As glycemic parameters including glycemia, insulinemia and C-peptide decreased post-operatively and glicentin progressively increased, it is not surprising that ratios of glicentin reported to glycemic parameters increased over time.…”

Section: Discussionsupporting

confidence: 92%

Fasting Circulating Glicentin Increases After Bariatric Surgery

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 92%

Fasting Circulating Glicentin Increases After Bariatric Surgery

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In several studies, the influence of MDA on LDL-C was also observed in different morbidities [19][20][21][22]. The total antioxidant capacity (TAC), homocysteinemia, C-reactive protein (CRP), alpha-1-acid glycoprotein (AGP), waist circumference (WC) and cholesterol intake, based on methodological protocols for different morbidities, LDL-C levels were correlated with these variables [11,[23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

The direct correlation between oxidative stress and LDL-C levels in adults is maintained by the Friedewald and Martin equations, but the methylation levels in the MTHFR and ADRB3 genes differ

et al. 2020

View full text Add to dashboard Cite

Low-density lipoprotein (LDL-C) concentrations are a standard of care in the prevention of cardiovascular disease and are influenced by different factors. This study compared the LDL-C concentrations estimated by two different equations and determined their associations with inflammatory status, oxidative stress, anthropometric variables, food intake and DNA methylation levels in the LPL, ADRB3 and MTHFR genes. A cross-sectional population-based study was conducted with 236 adults (median age 37.5 years) of both sexes from the municipality of João Pessoa, Paraíba, Brazil. The LDL-C concentrations were estimated according to the Friedewald and Martin equations. LPL, ADRB3 and MTHFR gene methylation levels; malondialdehyde levels; total antioxidant capacity; ultra-sensitive C-reactive protein, alpha-1-acid glycoprotein, homocysteine, cobalamin, and folic acid levels; usual dietary intake; and epidemiological variables were also determined. For each unit increase in malondialdehyde concentration there was an increase in the LDL-C concentration from 6.25 to 10.29 mg/dL (p <0.000). Based on the Martin equation (≥70 mg/dL), there was a decrease in the DNA methylation levels in the ADRB3 gene and an increase in the DNA methylation levels in the MTHFR gene (p <0.05). There was a positive relation of homocysteine and cholesterol intake on LDL-C concentrations estimated according to the Friedewald equation and of waist circumference and age based on the two estimates. It is concluded the LDL-C concentrations estimated by the Friedewald and Martin equations were different, and the Friedewald equation values were significantly lower than those obtained by the Martin equation. MDA was the variable that was most positively associated with the estimated LDL-C levels in all multivariate models. Significant relationships were observed based on the two estimates and occurred for most variables. The methylation levels of the ADRB3 and MTHFR genes were different according to the Martin equation at low LDL-C concentrations (70 mg/dL).

show abstract

“…Dentre as funções das proteínas encontradas, destacam-se: proteínas relacionadas ao metabolismo lipídico e glicídico (ASLEH et al, 2006;DABROWSKA et al, 2015;IX et al, 2006;JENSEN et al, 2014;KOHAN et al, 2015;LEE et al, 2010;MANSUY-AUBERT et al, 2013;PICHÉ et al, 2005 AHSAN; KHAN, 2013); à coagulação sanguínea (CALDER et al, 2013;TRACY et al, 1999) e proteínas de fase aguda (ENGSTRÖM et al, 2007;LEE et al, 2010;LEE et al, 2015;LUO et al, 2015;OLIVEIRA et al, 2015;ORTIZ et al, 2014;SITAR;AYDIN;CAKATAY, 2013;TESSEROMATIS et al, 2011;VAN CAMPENHOUT et al, 2003).…”

Section: Análise Quantitativa Dos Dados Da Proteômicaunclassified

“…Alpha-1-acid glycoprotein 1 (A1AG1) é uma proteína plasmática de fase aguda sintetizada pelo fígado e sua concentração sérica aumenta em resposta à lesão tecidual sistêmica, inflamação, infecção ou câncer (TESSEROMATIS et al, 2011). A1AG1 é considerada uma proteína de fase aguda positiva e um indicador de inflamação (LEE et al, 2015;LUO et al, 2015;OLIVEIRA et al, 2015;TESSEROMATIS et al, 2011).…”

Section: Alpha-1-acid Glycoproteinunclassified

Proteômica em dois grupos metabólicos de crianças e adolescentes com diferente perfil lipídico e glicídico submetidos à suplementação de micronutrientes

Landell¹

View full text Add to dashboard Cite

Eu, Prof(a). Dr(a). Jacqueline Pontes Monteiro declaro para os devidos fins que CAROLINA DE ALMEIDA COELHO LANDELL, aluna de Doutorado regularmente matriculada no Programa de Pós-Graduação Saúde da Criança e do Adolescente, sob minha orientação, está apta à defesa pública de sua tese Proteômica em dois grupos metabólicos de crianças e adolescentes com diferente perfil lipídico e glicídico submetidos à suplementação de micronutrientes, que está sendo depositada na presente data. A presente tese teve como objetivo descrever dois diferentes grupos metabólicos em um estudo de intervenção nutricional; descrever o perfil lipídico, os níveis de glicose e os dados proteômicos ao longo do estudo nesses dois grupos. A técnica estatística "k-means clustering" foi utilizada para alocar os participantes em dois grupos metabólicos distintos (cluster 1 e cluster 2), de acordo com os perfis glicídicos e lipídicos (glicemia, triglicerídeos, colesterol total, LDL, HDL e VLDL colesterol) que os indivíduos apresentaram nos três momentos do estudo. O cluster 1 (n = 111) teve melhor perfil glicolipídico e também apresentou menores valores para índice de massa corporal, circunferência de cintura e porcentagem de gordura corporal nos três momentos do estudo, comparado ao cluster 2 (n = 25). A ingestão alimentar não diferiu entre os clusters em nenhum momento do estudo. Com a suplementação de micronutrientes, o cluster 1 apresentou redução de glicemia, LDL e colesterol total, além de diminuir sua ingestão de energia, carboidrato, lipídeo e proteína, enquanto o cluster 2 reduziu LDL, colesterol total e HDL e não alterou sua ingestão de energia e macronutrientes. Foi identificada a expressão de 20 proteínas no plasma dos indivíduos dos clusters 1 e 2, sendo que a maioria delas evoluiu de maneira diferente entre os dois grupos após a intervenção. Com a suplementação, o cluster 1 apresentou aumento na expressão de alpha-1-acid glycoprotein 1, alpha-2-HS-glycoprotein, ceruloplasmin e de fibrinogen alpha, beta e gamma chain, bem como redução na expressão de apolipoprotein A-IV, haptoglobin, Ig alpha-1 chain C region, serotransferrin e vitamin D-binding protein. No mesmo período, o cluster 2 mostrou aumento de alpha-1-antitrypsin, ceruloplasmin, haptoglobin, Ig alpha-1 chain C region e plasma protease C1 inhibitor, além de diminuição na expressão de alpha-1-acid glycoprotein 1 e de fibrinogen alpha, beta e gamma chain. É possível que tenha ocorrido aumento de expressão de proteínas que podem ter auxiliado na melhora do perfil glico-lipídico dos participantes. O cluster de pior perfil parece ter se beneficiado mais com a intervenção em relação à expressão de proteínas do que o cluster de melhor perfil.

show abstract

Impact of Roux-en-Y gastric bypass on lipid and inflammatory profiles

Abstract: Roux-en-Y gastric bypass promoted a decrease in plasma concentrations of CRP and Alpha-1-acid glycoprotein, improving lipid and inflammatory profiles.

Cited by 6 publications

References 26 publications

Fasting Circulating Glicentin Increases After Bariatric Surgery

Fasting Circulating Glicentin Increases After Bariatric Surgery

The direct correlation between oxidative stress and LDL-C levels in adults is maintained by the Friedewald and Martin equations, but the methylation levels in the MTHFR and ADRB3 genes differ

Proteômica em dois grupos metabólicos de crianças e adolescentes com diferente perfil lipídico e glicídico submetidos à suplementação de micronutrientes

Contact Info

Product

Resources

About