Crohn's disease (CD) is a chronic, multifocal transmural inflammatory disease that affects any portion of the gastrointestinal tract. Clinically, it presents with intermittent abdominal pain, diarrhea, hematochezia, failure to thrive, fever and weight loss. 1,2 The pathophysiology of the disease is dictated by the interaction of environmental and personal factors including diet with effects on the microbiome and genetic predisposition. The natural history is multifaceted as the disease is associated with a spectrum of clinical phenotypes and complications requiring surgical intervention. 3 2 | PRE VALEN CE/IN CIDEN CE Crohn's disease was initially thought to be a disease affecting primarily Ashkenazi Jewish patients, Northern European countries and the United States. It has been estimated that prevalence of CD in the United States is approximately 201/100 000 with an incidence of 3.1-20.2/100 000. 4 Currently, over 1.5 million patients in the United States and >2 million in Europe are known to be affected by the disease. 4-7 Over the past decade, the incidence of CD has been increasing particularly in populations previously regarded to be lowrisk, especially in Asia. 8,9