Metastatic pulmonary calcification: contribution of imaging to noninvasive diagnosis

Torres, Pedro Paulo Teixeira e Silva

doi:10.1590/0100-3984.2017.50.5e2

Cited by 2 publications

(5 citation statements)

References 16 publications

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“…Different patterns of MPC may be appreciated on HRCT scan of the lungs and include the presence of numerous diffuse calcified nodules, patchy ground glass opacification or confluent hyperdense consolidation [1] , [2] , [3] .…”

Section: Discussionmentioning

confidence: 99%

“…Technetium 99m Methylene Diphosphonate nuclear scan (TC-99m MDP) may a be a useful tool in early detection of this metabolic disease which usually shows intense uptake of the tracer in the involved lung parenchyma [3 , 4 , 8] . 99m Tc MDP scintigraphy can evaluate metastatic calcification in other organs concurrently.…”

Section: Discussionmentioning

confidence: 99%

“…Metastatic pulmonary calcification (MPC) is considered to be a metabolic lung disease with disturbance in the calcium /phosphorus metabolism and its etiology is subdivided into benign and malignant causes [1] , [2] , [3] . It is seen most commonly in patients undergoing hemodialysis due to end stage renal disease and is often an underdiagnosed condition as almost 60-75% of patients on hemodialysis appear to have MPC at autopsy [4 , 5] .…”

Section: Introductionmentioning

confidence: 99%

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Metastatic pulmonary calcifications postcardiac transplant in a 15-year-old patient: A case report and review of literature

AlNuaimi

Elkaissi

Wahla

et al. 2020

Radiology Case Reports

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Metastatic pulmonary calcification is a metabolic lung disease that occurs due to a prolonged hypercalcemic state where calcium salts precipitate into numerous foci or nodules of fluffy calcifications in the lung apices, usually bilaterally. Calcifications can also occur in other organs such as in the stomach and the kidneys. It is often underdiagnosed and is usually associated with end stage renal failure and resultant secondary hyperparathyroidism. Nevertheless, it is rarely reported in the postcardiac surgery status and cardiac transplant patients. We present a case of a 15-year-old male patient with a recent history of cardiac transplant due to a complex congenital heart disease where findings of extensive metastatic pulmonary calcifications were seen a routine follow-up chest radiograph. Clinical manifestations of metastatic pulmonary calcifications can range from having no symptoms or mild dyspnea on exertion to fulminant respiratory failure. Therefore, early recognition of imaging features and initiation of proper management is crucial to the patient's outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metastatic pulmonary calcifications postcardiac transplant in a 15-year-old patient: A case report and review of literature

AlNuaimi

Elkaissi

Wahla

et al. 2020

Radiology Case Reports

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“…However, antemortem diagnosis was not routinely made until the advent of computed tomography (CT) on which MPC was first described in 1989 3 . Computed tomography subsequently has become the mainstay of diagnosis, typically obviating the need for lung biopsy 3–5 . Treatment of MPC is aimed at resolving the underlying disease, such as renal failure or hyperparathyroidism, to correct hypercalcemia or hyperphosphatemia 1 .…”

mentioning

confidence: 99%

“…3 Computed tomography subsequently has become the mainstay of diagnosis, typically obviating the need for lung biopsy. [3][4][5] Treatment of MPC is aimed at resolving the underlying disease, such as renal failure or hyperparathyroidism, to correct hypercalcemia or hyperphosphatemia. 1 Early diagnosis of MPC is beneficial, because lack of treatment may be associated with acute respiratory failure, leading to death.…”

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confidence: 99%

Metastatic Pulmonary Calcification: Single-Center Review of Typical and Atypical Imaging Features

Chen

Hossain

Jeudy

et al. 2023

J Comput Assist Tomogr

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Purpose The purpose of this study is to bring attention to an atypical form of metastatic pulmonary calcification, which is conventionally described as a metabolic process with upper lobe predominance in patients with a specific clinical history, which has not been reported as a distinct entity. Methods Patients with metastatic pulmonary calcification (MPC) were first identified with mPower keyword search, including MPC or metastatic calcifications on computed tomography chest radiological reports. Patients were then filtered on likelihood of MPC based off imaging reports. Images were then reviewed by three senior radiologists for pertinent characteristics such as location of MPC, degree of calcifications and pleural effusions. Based on the predominant location of MPC, cases were labeled as either typical or atypical. Clinical and imaging characteristics relevant to MPC were noted and compared across typical and atypical cases. Results In our study, we describe 25 patients with MPC, 13 defined as typical MPC and 12 with atypical MPC. Through consensus of senior radiologists, MPC was deemed to be mild (52%), moderate (44%), or severe (4%). Twenty-three patients (92%) had underlying renal disease including 21 requiring dialysis at the time of diagnosis. Outside of age at diagnosis, there was no significant clinical difference between the two groups. Evaluation of imaging characteristics (average HU attenuation, 267; range, 186–295), pattern and distribution of calcification, and clinical history strongly supported a diagnosis of atypical MPC. Conclusion This study presents several cases of lower lobe subpleural MPC associated with pleural effusions, which has not been reported as a distinct entity, despite comprising a significant portion of MPC cases at our institution.

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Metastatic pulmonary calcification: contribution of imaging to noninvasive diagnosis

Cited by 2 publications

References 16 publications

Metastatic pulmonary calcifications postcardiac transplant in a 15-year-old patient: A case report and review of literature

Metastatic pulmonary calcifications postcardiac transplant in a 15-year-old patient: A case report and review of literature

Metastatic Pulmonary Calcification: Single-Center Review of Typical and Atypical Imaging Features

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