2014
DOI: 10.1590/0074-0276140193
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Abstract: The interferon (IFN)-γ response to peptides can be a useful diagnostic marker of Mycobacterium tuberculosis (MTB) latent infection. We identified promiscuous and potentially protective CD4+ T-cell epitopes from the most conserved regions of MTB antigenic proteins by scanning the MTB antigenic proteins GroEL2, phosphate-binding protein 1 precursor and 19 kDa antigen with the TEPITOPE algorithm. Seven peptide sequences predicted to bind to multiple human leukocyte antigen (HLA)-DR molecules were synthesised and … Show more

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Cited by 3 publications
(5 citation statements)
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References 39 publications
(45 reference statements)
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“…This implies the presence of either dead or live and presumably sequestered mycobacteria, able to sustain T cell activation. Persistent antigen specific T cells are presumed to play a role in maintenance of latent TB, but in contrast, T cells from latently infected individuals express low levels of activation molecules on TB specific cells, as demonstrated in many studies including our own [25,[31][32][33]. The clinical significance of persistent activation molecules on TB specific cells after therapy is not clear.…”
Section: Discussionmentioning
confidence: 92%
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“…This implies the presence of either dead or live and presumably sequestered mycobacteria, able to sustain T cell activation. Persistent antigen specific T cells are presumed to play a role in maintenance of latent TB, but in contrast, T cells from latently infected individuals express low levels of activation molecules on TB specific cells, as demonstrated in many studies including our own [25,[31][32][33]. The clinical significance of persistent activation molecules on TB specific cells after therapy is not clear.…”
Section: Discussionmentioning
confidence: 92%
“…T cell stimulation in response to specific antigen is well described to result in the induction of markers for activation and proliferation which subsequently decay as the stimulus is removed [19][20][21]. The observation here that of the decrease in expression of such molecules over many months of therapy presumably reflects the gradual diminution of mycobacterial load and disappearance of pro-inflammatory and/or presence of anti-inflammatory mediators [19][20][21][22][23][24][25][26]30] Further research is needed to define non-antigen specific activation in human disease, its loss with disease resolution, and its association with other biomarkers.…”
Section: Discussionmentioning
confidence: 99%
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“…Both tests are based on the cell-mediated immune response to MTB antigens. The IGRA is an immune response to merely 2 or 3 tuberculosis antigens but the TST is immune response to 200 tuberculosis antigens [2,3,5]. From positive TST to negative TST is known reversion.…”
Section: Discussionmentioning
confidence: 99%