2014
DOI: 10.1590/0074-0276140123
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Abstract: Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence … Show more

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Cited by 66 publications
(102 citation statements)
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References 97 publications
(88 reference statements)
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“…According to the previous epidemiologic studies, the prevalence rate of G6PD deficiency is higher among males than females [11,27,[30][31][32][33][34][35]. In line with these studies, the current study also revealed a higher prevalence rate of G6PD deficiency among males compared to the females.…”
Section: Discussionsupporting
confidence: 88%
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“…According to the previous epidemiologic studies, the prevalence rate of G6PD deficiency is higher among males than females [11,27,[30][31][32][33][34][35]. In line with these studies, the current study also revealed a higher prevalence rate of G6PD deficiency among males compared to the females.…”
Section: Discussionsupporting
confidence: 88%
“…There are some evidences that the frequency of G6PD deficiency differed across the world depending on the ethnic groups and regions [11,21,25]. On the contrary, in the present study, the distribution of G6PD deficiency was the same among the Iranian and foreign immigrants (Afghan and Pakistani participants).…”
Section: Discussioncontrasting
confidence: 82%
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“…Patients with G6PDd should not take drugs that cause high oxidative stress such as primaquine, an antimalarial, because of an associated risk of serious side effects, including acute hemolysis and further renal failure. Deaths resulting from these adverse effects, and attributed to primaquine intake, have been reported 1,2 . However, primaquine is the only effective drug for radical cure of Plasmodium vivax malaria commercially available.…”
Section: Dear Editormentioning
confidence: 99%