2014
DOI: 10.1590/0074-0276140085
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: A cohort of 123 adult contacts was followed for 18‐24 months (86 completed the follow-up) to compare conversion and reversion rates based on two serial measures of QuantiFERON (QFT) and tuberculin skin test (TST) (PPD from TUBERSOL, Aventis Pasteur, Canada) for diagnosing latent tuberculosis (TB) in household contacts of TB patients using conventional (C) and borderline zone (BZ) definitions. Questionnaires were used to obtain information regarding TB exposure, TB risk factors and socio-demographic data. QFT (… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
5
0

Year Published

2017
2017
2022
2022

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 7 publications
(5 citation statements)
references
References 33 publications
0
5
0
Order By: Relevance
“…For example, the TST is not completely specific, because patients that have been vaccinated with the Bacillus Calmette Guerin (BCG) vaccine will show a positive result ( 62 ). On the other hand, the IGRA tests have yielded high rates of conversions between positive and negative latent tuberculosis infection (LTBI), mainly due to the cutoff values ( 63 ). Although these tests are highly accepted, they are not foolproof and represent a challenge when trying to correctly diagnose patients.…”
Section: Tuberculosismentioning
confidence: 99%
“…For example, the TST is not completely specific, because patients that have been vaccinated with the Bacillus Calmette Guerin (BCG) vaccine will show a positive result ( 62 ). On the other hand, the IGRA tests have yielded high rates of conversions between positive and negative latent tuberculosis infection (LTBI), mainly due to the cutoff values ( 63 ). Although these tests are highly accepted, they are not foolproof and represent a challenge when trying to correctly diagnose patients.…”
Section: Tuberculosismentioning
confidence: 99%
“…There were five individuals with tests that reverted from positive to negative at follow-up, and it has been suggested that borderline results (falling within an "uncertain range" of e.g., 0.22-0.71 IU/ml) may be more likely to change at follow-up [20,24]; however, we did not see an association with borderline positivity of the first and the outcome of the second test. The apparent randomness and inconsistency of reversions at follow-up has been identified in previous research [25,26] and changes have not been explained by occupational exposure in HCW [27]. Therefore, reversions identified in serial QTF testing should be interpreted with caution.…”
Section: Discussionmentioning
confidence: 76%
“…0.22-0.71 IU/mL) may be more likely to change at follow-up (20,24); however, we did not see an association with borderline positivity of the rst and the outcome of the second test. The apparent randomness and inconsistency of reversions at follow-up has been identi ed in previous research (25,26) and changes have not been explained by occupational exposure in HCW (27). Therefore, reversions identi ed in serial QTF testing should be interpreted with caution.…”
Section: Discussionmentioning
confidence: 79%