2014
DOI: 10.1590/0074-0276140028
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Abstract: American cutaneous leishmaniasis (ACL) is a vector-transmitted infectious disease with an estimated 1.5 million new cases per year. In Brazil, ACL represents a significant public health problem, with approximately 30,000 new reported cases annually, representing an incidence of 18.5 cases per 100,000 inhabitants. Corte de Pedra is in a region endemic for ACL in the state of Bahia (BA), northeastern Brazil, with 500-1,300 patients treated annually. Over the last decade, population and family-based candidate gen… Show more

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Cited by 37 publications
(35 citation statements)
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“…Indeed, recent studies show that LRV1 in Lbr clinical isolates correlates with drug treatment failure (16), as was also seen in Lgy (20). Thus, although other parasite or host factors may play a significant role in the development of MCL (21,22), current data now bolstered by our studies of isogenic LRV1 + /negative lines support a role for LRV1 in the severity of human leishmaniasis caused by Lbr. (30), and clonal lines were derived, validated, and used.…”
Section: Discussionsupporting
confidence: 72%
See 1 more Smart Citation
“…Indeed, recent studies show that LRV1 in Lbr clinical isolates correlates with drug treatment failure (16), as was also seen in Lgy (20). Thus, although other parasite or host factors may play a significant role in the development of MCL (21,22), current data now bolstered by our studies of isogenic LRV1 + /negative lines support a role for LRV1 in the severity of human leishmaniasis caused by Lbr. (30), and clonal lines were derived, validated, and used.…”
Section: Discussionsupporting
confidence: 72%
“…Recent studies show that LRV1 in Lbr and Lgy clinical isolates correlates with drug treatment failure (16,20). Thus, although other parasite or host factors may play a significant role in the development of MCL (21,22), current data support a role for LRV1 in exacerbating the pathogenesis of human leishmaniasis caused by Lbr and Lgy. A similar role in pathogenicity has been proposed for the Trichomonas vaginalis totiviruses (23).…”
Section: Significancementioning
confidence: 77%
“…However, in some instances, metastasis and relapse after drug treatment also occur in the absence of LRV1 (13). The basis for these discrepancies is of considerable interest; the hypothesis put forward includes the significance of the presence of other parasite species, microbial or host factors that are known to play an important role in the development of MCL (14)(15)(16).…”
mentioning
confidence: 99%
“…Although in some studies LRV1 was not correlated with MCL clinical manifestations (17,18), in others there was a strong association (6,19,20). The basis for these discrepancies is of considerable interest, hypotheses for which include other parasite or host factors known to play a significant role in the development of MCL (13,21,22), or…”
mentioning
confidence: 99%