The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii

Ghafourian, Sobhan; Good, Liam; Hamat, Rukman Awang; Soheili, Sara; Sadeghifard, Nourkhoda; Neela, Vasantha Kumari

doi:10.1590/0074-0276130601

Cited by 20 publications

(17 citation statements)

References 9 publications

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“…The HigBA and SplTA TA systems were particularly common (88.6% predominance, taking into account the 476 clinical samples). Remarkably, in 46 of the A. baumannii isolates analyzed, expression of the HigBA toxin-antitoxin system was not observed (399,400). All of these toxin-antitoxin systems were found in most clinical isolates of A. baumannii belonging to the ECI and ECII groups worldwide.…”

Section: Toxin-antitoxin Systemsmentioning

confidence: 94%

Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments

et al. 2018

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SUMMARYPathogens that infect the gastrointestinal and respiratory tracts are subjected to intense pressure due to the environmental conditions of the surroundings. This pressure has led to the development of mechanisms of bacterial tolerance or persistence which enable microorganisms to survive in these locations. In this review, we analyze the general stress response (RpoS mediated), reactive oxygen species (ROS) tolerance, energy metabolism, drug efflux pumps, SOS response, quorum sensing (QS) bacterial communication, (p)ppGpp signaling, and toxin-antitoxin (TA) systems of pathogens, such as , spp., spp., spp., , spp., spp., spp., and , all of which inhabit the gastrointestinal tract. The following respiratory tract pathogens are also considered:, ,, , and Knowledge of the molecular mechanisms regulating the bacterial tolerance and persistence phenotypes is essential in the fight against multiresistant pathogens, as it will enable the identification of new targets for developing innovative anti-infective treatments.

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Section: Toxin-antitoxin Systemsmentioning

confidence: 94%

Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments

et al. 2018

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“…Firstly, the target should be prevalent in the subjected population. So, the bioinformatics analysis helps to find the prevalent target genes and it could have confirmed by experimental analysis (7). Therefore, this type of analysis is cost and time effective in the laboratories.…”

Section: Discussionmentioning

confidence: 99%

“…Because of attractive data in genomic databases, it is suggested the bacteria firstly go under the bioinformatics analysis to gain the accurate data (6). Toxin antitoxin (TA) systems in bacteria are currently attractive antimicrobial target (7). There are six different types and mostly are known as a regulon of virulence and alternatively antimicrobial resistant genes (8).…”

Section: Introductionmentioning

confidence: 99%

Potent antimicrobial target in Staphylococcus aureus by bioinformatics analysis

Mahmoudi

Mohamadian

Maleki

et al. 2019

Preprint

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Objectives: Staphylococcus aureus could be considerable pathogenic bacterium because it can be changed from a microbiome to a lethal pathogen. Another remarkable ability of this bacterium is its colonization ability, which has been cloned in one-third of the world's population. Also, one of the most important issue in S. aureus is its severe resistance to antibiotics, which can lead to failure in antimicrobial therapy in many diseases such as abscesses, sinusitis, food poisoning, toxic shock syndrome, atopic dermatitis as well as it is one of the five major causes of nosocomial infections, especially post- surgical ulcers. therefore, find a novel antimicrobial target for S. aureus is crucial. Some studies demonstrated that toxin antitoxin systems can be the regulon for controlling the pathogenic bacteria. To identify the reliable antimicrobial targets, bioinformatics analysis before any experimental study could be helpful. Results: we evaluate the potent TA loci of 36 S. aureus strains by bioinformatics analysis. As regards, this analysis was performed with Rasta data base, toxin antitoxin systems distributions were seen in all scores and the htx-xre has the preponderance total frequency, which we hope will be beneficial for further researches.

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“…The most common type II TA system in bacteria is mazEF [12][13][14], relEB [15], mqsRA [16]. Several studies suggested the role of TA systems in biofilm formation.…”

Section: Discussionmentioning

confidence: 99%

The Role of Peganum harmala Ethanolic Extract and Type II Toxin Antitoxin System in Biofilm Formation

et al. 2017

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Toxin antitoxin system is a regulatory system that antitoxin inhibits the toxin. We aimed to determine the role of TA loci in biofilm formation in K. pneumoniae clinical and environmental isolates; also inhibition of biofilm formation by Peganum harmala. So, 40 K. pneumoniae clinical and environmental isolates were subjected for PCR to determine the frequency of mazEF, relEB, and mqsRA TA loci. Biofilm formation assay subjected for all isolates. Then, P. harmala was tested against positive biofilm formation strains. Our results demonstrated that relBE TA loci were dominant TA loci; whereas mqsRA TA loci were negative in all isolates. The most environmental isolates showed weak and no biofilm formation while strong and moderate biofilm formation observed in clinical isolates. Biofilm formations by K. pneumoniae in 9 ug/ml concentration were inhibited by P. harmala. In vivo study suggested to be performed to introduce Peganum harmala as anti-biofilm formation in K. pneumoniae.

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The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii

Cited by 20 publications

References 9 publications

Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments

Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments

Potent antimicrobial target in Staphylococcus aureus by bioinformatics analysis

The Role of Peganum harmala Ethanolic Extract and Type II Toxin Antitoxin System in Biofilm Formation

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