2014
DOI: 10.1590/0074-0276130563
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Abstract: Antimony compounds are the cornerstone treatments for tegumentary leishmaniasis. The reactivation of herpes virus is a side effect described in few reports. We conducted an observational study to describe the incidence of herpes zoster reactivation during treatment with antimony compounds. The global incidence of herpes zoster is approximately 2.5 cases per 1,000 persons per month (or 30 cases per 1,000 persons per year). The estimated incidence of herpes zoster in patients undergoing antimony therapy is highe… Show more

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“…Reactivation of latent viruses, such as several herpes viruses, frequently occurs in older people that are more likely to be under conditions of immunosuppression; whereas herpes viruses are infrequently re-activated in younger adults, particularly in those with normally functioning immune systems (Effros 2011). There are several reports of antimony activating latent varicella zoster virus among patients treated for leishmaniasis or schistosomiasis with antimonial compounds (Barros et al 2014; Hartzell et al 2006; Ritchken and Kantor 1947). Since antimony accumulates highly and rapidly in blood cells after in vivo administration (Winship 1987) and also induces oxidative damage in leukocyte cells (Muller et al 1998; Wyllie and Fairlamb 2006), antimony exposure may contribute to cumulative oxidative damage.…”
Section: Discussionmentioning
confidence: 99%
“…Reactivation of latent viruses, such as several herpes viruses, frequently occurs in older people that are more likely to be under conditions of immunosuppression; whereas herpes viruses are infrequently re-activated in younger adults, particularly in those with normally functioning immune systems (Effros 2011). There are several reports of antimony activating latent varicella zoster virus among patients treated for leishmaniasis or schistosomiasis with antimonial compounds (Barros et al 2014; Hartzell et al 2006; Ritchken and Kantor 1947). Since antimony accumulates highly and rapidly in blood cells after in vivo administration (Winship 1987) and also induces oxidative damage in leukocyte cells (Muller et al 1998; Wyllie and Fairlamb 2006), antimony exposure may contribute to cumulative oxidative damage.…”
Section: Discussionmentioning
confidence: 99%