2014
DOI: 10.1590/0074-0276130531
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Abstract: We have analysed the whole mitochondrial (mt) genome sequences (each ~6 kilo nucleotide base pairs in length) of four field isolates of the malaria parasite Plasmodium falciparum collected from different locations in India. Comparative genomic analyses of mt genome sequences revealed three novel India-specific single nucleotide polymorphisms. In general, high mt genome diversity was found in Indian P. falciparum, at a level comparable to African isolates. A population phylogenetic tree placed the presently seq… Show more

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Cited by 7 publications
(9 citation statements)
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“…Interestingly, Indian P. falciparum shares many of the genetic properties with African isolates (see also Tyagi et al . ), but are very different from Asian P. falciparum . Considering Indian P. falciparum to be genetically more identical to Africa than to Asia, it seems very much probable that P. falciparum might have existed in India and Africa for a long time before being introduced into Southeast Asia (D. J. Conway, personal communication).…”
Section: Discussionmentioning
confidence: 79%
“…Interestingly, Indian P. falciparum shares many of the genetic properties with African isolates (see also Tyagi et al . ), but are very different from Asian P. falciparum . Considering Indian P. falciparum to be genetically more identical to Africa than to Asia, it seems very much probable that P. falciparum might have existed in India and Africa for a long time before being introduced into Southeast Asia (D. J. Conway, personal communication).…”
Section: Discussionmentioning
confidence: 79%
“…Due to their non-recombining and co-inherited evolutionary nature, apicoplast and mitochondrial genomes have recently been used in the development of barcoding tools for tracking Plasmodium spp. [2628]. …”
Section: Introductionmentioning
confidence: 99%
“…Publicly available P . falciparum full mitochondrial genome sequences (n = 745) were downloaded from NCBI Nucleotide [13], with geographical origins from the following reported regions: Africa, Brazil, Central America, Ghana, Haiti, India, Papa New Guinea, Philippines, Solomon Islands, South America, Southeast Asia, Tanzania, Thailand, and Vanuatu [6,8,9,1416].…”
Section: Methodsmentioning
confidence: 99%