Detection of the pandemic norovirus variant GII.4 Sydney 2012 in Rio Branco, state of Acre, northern Brazil

Silva, Luciana Damascena da; Rodrigues, E. L; Lucena, Maria Silvia Sousa de; Lima, Ian Carlos Gomes de; Oliveira, Darleise de Sousa; Soares, Luana da Silva; Mascarenhas, Joana D’Arc Pereira; Linhares, Alexandre da Costa; Gabbay, Yvone Benchimol

doi:10.1590/0074-0276130293

Cited by 19 publications

(19 citation statements)

References 22 publications

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“…In the present study, the frequency observed (4.7%) was lower than that observed in Rio de Janeiro (13.5%) and São Paulo (28.2%), but similar to the 3.9% and 5.4% found in Belém, which is also in the Amazon Region. In Rio Branco City, few studies have been performed involving only NoV genotyping characterization, reinforcing the importance of the data presented herein.…”

Section: Discussionmentioning

confidence: 61%

“…Among these we can highlight: NoV infections in Belém (inpatients: 36.5%), NoV in cruise ships (outbreak: 3%), outbreak of acute diarrheal disease in Paraíso do Tocantins (4%), infections among hospitalized children in Porto Velho (7.8%), detection of a recombinant GII.7/GII.20 strain in an African‐descendant community (19.7%), and NoV in high prevalence among sporadic cases in Manaus (35.2%) . NoV was previously reported in Rio Branco, Acre, in two situations; detection of genotypes GII.16 and GII.17 in a study involving Brazil states, as well as the first description of the GII.4 Sydney variant in Brazil …”

Section: Introductionmentioning

confidence: 99%

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Epidemiological and molecular investigation of norovirus and astrovirus infections in Rio Branco, Acre, Northern Brazil: A retrospective study

Bitencurt

Siqueira

Medeiros

et al. 2019

Journal of Medical Virology

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Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis (AGE) outbreaks worldwide, with infections reported in semiclosed environments, particularly in hospitals and nursing homes. Astrovirus (HAstV) is prevalent worldwide, especially in developing countries. We aimed to determine the prevalence, spatial distribution, and genetic diversity of NoV and HAstV in children under 5 years of age in Rio Branco city, Acre State, Amazon Region, Brazil. Stool samples from children with (n = 240) and without (n = 248) AGE were collected from January to December 2012 from seven neighborhoods. The overall NoV prevalence was 12.3% (60 of 488); representing 15.8% (38 of 240) of the symptomatic samples and 8.9% (22 of 248) of the controls. HAstVs infection was observed in 4.7% (23 of 488) of the samples tested, 6.2% (15 of 240) of AGE cases, and 2.4% (6 of 248) of the controls (plus two without information about feces consistency). Infections were found in all age groups with higher frequency in children less than two years of age, for both viruses. NoV was detected in all neighborhoods, with a higher concentration in the fourth (30%; 18 of 60). NoV nucleotide sequencing performed in 86.7% (52 of 60) of the positive samples showed the circulation of the strains GII.4 (57.7%; 30 of 52), GIIPe/GII.4 (19.2%; 10 of 52), GII.7, GII.Pg/GII.1, and GII.Pc (3.8%; 2 of 52 for each), GII.6 and GII.Pg (1.9%; 1 of 52 for each), and GI.3 (7.7%; 4 of 52). Three GII.4 variants were detected: Den Haag_2006b (n = 1), New Orleans_2009 (n = 1), and Sydney_2012 (n = 14). HAstV types HAstV‐1a (81.8%; 9 of 11) and HAstV‐2c (18.2%; 2 of 11) were observed in the 47.8% (11 of 23) of characterized samples. This is the first data obtained in Acre State regarding the prevalence of these viruses and provides epidemiological and molecular information for a better understanding of their role among children with and without AGE.

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Section: Discussionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Epidemiological and molecular investigation of norovirus and astrovirus infections in Rio Branco, Acre, Northern Brazil: A retrospective study

Bitencurt

Siqueira

Medeiros

et al. 2019

Journal of Medical Virology

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“…In Brazil, GII.4 NoV is most frequently reported from emergency departments [5,6,29,30]. The presence of a variety of genotypes in Sergipe and the periodic shift of GII.4 variants (i.e., GII.4 New-Orleans_2009 and GII.4 Sydney_2012) reflects the emergence worldwide of GII.4 variants [29,[31][32][33][34][35][36], confirming that the NoV genotypes have a wide geographical distribution. The increased detection of GII.4 could be explained by GII.4 theoretically causing more severe disease than other genotypes [31,37], but GII.4 diarrhoea severity in our patients was similar to other genotypes and we do not have evidence of an increased severity.…”

Section: Discussionmentioning

confidence: 93%

Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil

Santos

Gurgel

Cavalcante

et al. 2017

Journal of Clinical Virology

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Running title: Norovirus diarrhoea in children in BrazilWord count: Abstract: 199. Manuscript: 2255. Highlights Gastroenteritis is one of the most important causes of morbidity and mortality in children.  Noroviruses are a leading cause of sporadic cases and outbreaks of acute gastroenteritis.  Norovirus annual detection rates increased over the study period.  The detection of norovirus was higher among young children. AbstractBackground: Gastroenteritis is one of the most important causes of morbidity and mortality

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“…A recent report demonstrated this variant as circulating in Northern Brazil, causing sporadic cases in hospitalized children [41]. This strain also became the predominant NoV variant in the USA in 2012/2013, but its emergence was not associated with an increase in the activity of outbreaks when compared to previous seasons [63].…”

Section: Discussionmentioning

confidence: 95%

Temporal Dynamics of Norovirus GII.4 Variants in Brazil between 2004 and 2012

et al. 2014

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Noroviruses (NoVs) are the major cause of acute gastroenteritis outbreaks, and, despite a wide genetic diversity, genotype II.4 is the most prevalent strain worldwide. Mutations and homologous recombination have been proposed as mechanisms driving the epochal evolution of the GII.4, with the emergence of new variants in 1–3-year intervals causing global epidemics. There are no data reporting the dynamics of GII.4 variants along a specific period in Brazil. Therefore, to improve the understanding of the comportment of these variants in the country, the aim of this study was to evaluate the circulation of NoV GII.4 variants during a 9-year period in 3 out of 5 Brazilian regions. A total of 147 samples were sequenced, and a phylogenetic analysis of subdomain P2 demonstrated the circulation of six GII.4 variants, Asia_2003, Hunter_2004, Den Haag_2006b, Yerseke_2006a, New Orleans_2009, and Sydney_2012, during this period. The most prevalent variant was Den Haag_2006b, circulating in different Brazilian regions from 2006 to 2011. A Bayesian coalescent analysis was used to calculate the mean evolutionary rate of subdomain P2 as 7.3×10−3 (5.85×10−3–8.82×10−3) subst./site/year. These analyses also demonstrated that clade Den Haag_2006b experienced a rapid expansion in 2005 and another in 2008 after a period of decay. The evaluation of the temporal dynamics of NoV GII.4 in Brazil revealed a similar pattern, with few exceptions, to the worldwide observation. These data highlight the importance of surveillance for monitoring the emergence of new strains of NoV GII.4 and its impact on cases of acute gastroenteritis.

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Detection of the pandemic norovirus variant GII.4 Sydney 2012 in Rio Branco, state of Acre, northern Brazil

Cited by 19 publications

References 22 publications

Epidemiological and molecular investigation of norovirus and astrovirus infections in Rio Branco, Acre, Northern Brazil: A retrospective study

Epidemiological and molecular investigation of norovirus and astrovirus infections in Rio Branco, Acre, Northern Brazil: A retrospective study

Acute norovirus gastroenteritis in children in a highly rotavirus-vaccinated population in Northeast Brazil

Temporal Dynamics of Norovirus GII.4 Variants in Brazil between 2004 and 2012

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