New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study

Man, Adrian; Ciurea, Cristina Nicoleta; Păsăroiu, Dan; Savin, Ana Ioana; Toma, Felicia; Sular, Floredana; Santacroce, Luigì; Mare, Anca Delia

doi:10.1590/0074-02760170098

Cited by 36 publications

(25 citation statements)

References 25 publications

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“…C. albicans cells have the ability to modify their transcriptome by inhibiting the genes involved in gluconeogenesis, in the Krebs cycle or in the glyoxylate pathway, encouraging glycolysis and fermentation [ 86 ]. Other sugars such as fructose may change the outcome of an infection by increasing the generation time of Candida, thus inhibiting its growth rate [ 87 ].…”

Section: The Virulence Of Candida Sppmentioning

confidence: 99%

Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits

et al. 2020

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One of the most important questions in microbiology nowadays, is how apparently harmless, commensal yeasts like Candida spp. can cause a rising number of infections. The occurrence of the disease requires firstly the attachment to the host cells, followed by the invasion of the tissue. The adaptability translates into a rapid ability to respond to stress factors, to take up nutrients or to multiply under different conditions. By forming complex intracellular networks such as biofilms, Candida spp. become not only more refractive to antifungal therapies but also more prone to cause disease. The inter-microbial interactions can enhance the virulence of a strain. In vivo, the fungal cells face a multitude of challenges and, as a result, they develop complex strategies serving one ultimate goal: survival. This review presents the virulence factors of the most important Candida spp., contributing to a better understanding of the onset of candidiasis and raising awareness of the highly complex interspecies interactions that can change the outcome of the disease.

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Section: The Virulence Of Candida Sppmentioning

confidence: 99%

Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits

et al. 2020

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“…in DM patients. Man et al [50] evaluated the growth rate of C. albicans in the presence of different concentrations of glucose and fructose to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients. The authors determined that the glucose concentration is directly related to C. albicans growth, which may be linked to the frequent yeast infections that occur in non-controlled diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

“…This is an important outcome in oral Candida sp. biofilms, especially for patients who use prosthesis [50]. In fact, other carbon compounds such as sucrose, maltose, and lactose increase the fungal population density [43,51,52] and decrease the activity of antifungal agents.…”

Section: Introductionmentioning

confidence: 99%

Candida sp. Infections in Patients with Diabetes Mellitus

Rodrigues

Henriques

2019

JCM

179

144

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Candidiasis has increased substantially worldwide over recent decades and is a significant cause of morbidity and mortality, especially among critically ill patients. Diabetes mellitus (DM) is a metabolic disorder that predisposes individuals to fungal infections, including those related to Candida sp., due to a immunosuppressive effect on the patient. This review aims to discuss the latest studies regarding the occurrence of candidiasis on DM patients and the pathophysiology and etiology associated with these co-morbidities. A comprehensive review of the literature was undertaken. PubMed, Scopus, Elsevier’s ScienceDirect, and Springer’s SpringerLink databases were searched using well-defined search terms. Predefined inclusion and exclusion criteria were applied to classify relevant manuscripts. Results of the review show that DM patients have an increased susceptibility to Candida sp. infections which aggravates in the cases of uncontrolled hyperglycemia. The conclusion is that, for these patients, the hospitalization periods have increased and are commonly associated with the prolonged use of indwelling medical devices, which also increase the costs associated with disease management.

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“…A diet during the gestational period and in the 2 months following birth, therefore, during lactation, rich in L. rhamnosus and Bifidobacterium lactis brings beneficial effects on maternal health, fetal growth, and morbidity of the baby [15]. The same use of probiotics can guarantee, even in part, good bone regeneration and prevent mothers from any pathologies related to bone and dental loss [16], [17], [18].…”

Section: Discussionmentioning

confidence: 99%

Probiotics May Improve Serum Folate Availability in Pregnant Women: A Pilot Study

Ballini¹,

Signorini²,

Inchingolo³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Probiotics are living microorganisms that confer a health benefit when administered in adequate amounts. There is evidence in the current literature about the importance of probiotic use in pregnancy. The early supplementation of probiotics in the perinatal and postnatal periods seems to have a positive impact on the overall mother’s health and future health of infants. AIM: Our pilot study aimed to test the ability of specific probiotics strains in combination with the kiwi-unique enzyme actinidin to improve the availability of folic acid in 20 pregnant women. METHODS: We investigate 20 pregnant women in early (4–10 weeks) (6 patients), intermedium (11–20 weeks) (6 patients), and late (21–30 weeks) (8 patients) pregnancy. RESULTS: Our findings show that the tested formula promotes increased concentration of serum folate in women’s blood and contributes to the control of blood sugar and body weight, regardless of the gestational period (early, intermediate or late). CONCLUSIONS: Our data support the main results reported in the scientific literature about the importance of probiotics intake in pregnancy.

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New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study

Cited by 36 publications

References 25 publications

Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits

Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits

Candida sp. Infections in Patients with Diabetes Mellitus

Probiotics May Improve Serum Folate Availability in Pregnant Women: A Pilot Study

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