2014
DOI: 10.1590/0074-02760140208
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Trypanosoma cruzi infection may be caused by different strains with distinct discrete typing units (DTUs) that can result in variable clinical forms of chronic Chagas disease. The present study evaluates the immune response and cardiac lesions in dogs experimentally infected with different T. cruzi strains with distinct DTUs, namely, the Colombian (Col) and Y strains of TcI and TcII DTU, respectively. During infection with the Col strain, increased levels of alanine aminotransferase, erythrocytes, haematocrit … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

4
21
0
3

Year Published

2017
2017
2021
2021

Publication Types

Select...
6
2
1

Relationship

0
9

Authors

Journals

citations
Cited by 30 publications
(28 citation statements)
references
References 46 publications
4
21
0
3
Order By: Relevance
“…Thus far, autochthonous human cases of T. cruzi infection in the United States for which the DTU has been determined have consisted of TcI or unresolved TcII/V/VI, with no findings of TcIV in humans . Different strain types appear to have different pathologic effects in dogs and potentially in humans, and determination of which strain type a dog is infected with could provide clinical insight or be relevant for zoonotic concerns.…”
Section: Discussionmentioning
confidence: 99%
“…Thus far, autochthonous human cases of T. cruzi infection in the United States for which the DTU has been determined have consisted of TcI or unresolved TcII/V/VI, with no findings of TcIV in humans . Different strain types appear to have different pathologic effects in dogs and potentially in humans, and determination of which strain type a dog is infected with could provide clinical insight or be relevant for zoonotic concerns.…”
Section: Discussionmentioning
confidence: 99%
“…7). Crucially, different lineages may carry variable health implications for people (Macedo and Pena 1998) and probably also for dogs (Duz et al 2014), something that opens up the possibility that dogs could evolve a degree of resistance to one strain in one region, while remaining exposed to others there or elsewhere. Canine trypanosomiasis in Africa reveals precisely this situation, especially with regard to T. congolense and when comparing native African dogs to those introduced to the continent from Europe (Mitchell 2015).…”
Section: Canine Trypanosomiasismentioning
confidence: 99%
“…This technique has been shown to be repeatable and reproducible in dogs [19]. In addition, the canine model has gained wide acceptance as another experimental model to study a wide variety of conditions associated with ChD; however, the development of vaccines as a prophylactic method has not been widely addressed [20][21][22][23][24][25][26][27][28][29][30].…”
Section: Introductionmentioning
confidence: 99%