Current status of herpesvirus identification in the oral cavity of HIV-infected children

Abstract

Introduction: Some viruses of the Herpesviridae family are frequently the etiologic agents of oral lesions associated with HIV. The aim of this study was to identify the presence of herpes simplex virus types 1 and 2 (HSV-1, HSV-2), Varicella Zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), human herpesvirus type 6, type 7 and type 8 (HHV-6, HHV-7 and HHV-8) in the oral cavity of HIV-infected children/adolescents and verify the association between viral subtypes and clinical factors. Methods: The cells of oral mucosa were collected from 50 HIV infected children/adolescents, 3-13 years old (mean age 8.66). The majority (66%) of selected were girls, and they were all outpatients at the pediatric AIDS clinic of a public hospital in Rio de Janeiro. Nested-PCR was used to identify the viral types. Results: Absence of immunosuppression was observed in 66% of the children. Highly active antiretroviral therapy (HAART) was used by 72.1% of selected and moderate viral load was observed in 56% of the children/adolescents. Viral types were found in 86% of the children and the subtypes were: HSV-1 (4%), HSV-2 (2%), VZV (4%), EBV (0%), HCMV (24%), HHV6 (18%), HHV-7 (68%), HHV8 (0%). Conclusions: The use of HAART has helped to reduce oral lesions, especially with herpes virus infections. The health professionals who work with these patients should be aware of such lesions because of their predictive value and the herpes virus can be found circulating in the oral cavity without causing lesions.

Oral shedding of human herpesviruses in patients undergoing radiotherapy/chemotherapy for head and neck squamous cell carcinoma is not affected by xerostomia

“…It is known that HHV-6 and HHV-7 herpesviruses can be detected in healthy individuals who are asymptomatic [34] as exanthema subitum can be caused by a primary infection by HHV-6 and, less frequently, by HHV-7 [35,36]. The rate of oral excretion of HHV-6 in the healthy population is low (i.e.…”

“…HHV-6 and HHV-7 can be observed not only in healthy patients, but also in immunocompromised ones. A study by Pinheiro et al evaluated the oral desquamation in children with positive HIV status, reporting that 68% of them presented HHV-6 and 18% presented HHV-7 in the oral cavity [36]. HHV-6 oral shedding seems to be higher and continuous in children compared to adults [38].…”

Manifestações bucais em pacientes pediátricos infectados pelo HIV - uma revisão sistemática da literatura

“…De uma forma geral, as principais manifestações bucais presentes em pacientes pediátricos infectados pelo HIV encontradas nos artigos selecionados foram: cárie, candidose, queilite angular, eritema linear gengival, lesões na mucosa, patologias nas glândulas salivares, Sarcoma de Kaposi, Linfoma não Hodgkin, doenças fúngicas, doenças virais, doença periodontal, hipoplasia de esmalte e condiloma acuminado 1,[3][4][5][6][7][9][10][11] . Com relação às inferências deixadas pelos artigos, pode-se dizer que os pacientes pediátricos infectados pelo HIV, comumente, apresentam algum tipo de manifestação bucal em fases não específicas de sua infância, apesar de terem sido encontrados poucos estudos que correlacionam a temática com a Odontologia [1][2][3][4][5][6][7][9][10][11][12] .…”

“…Com relação às inferências deixadas pelos artigos, pode-se dizer que os pacientes pediátricos infectados pelo HIV, comumente, apresentam algum tipo de manifestação bucal em fases não específicas de sua infância, apesar de terem sido encontrados poucos estudos que correlacionam a temática com a Odontologia [1][2][3][4][5][6][7][9][10][11][12] . [1][2][3] .…”

Detecção dos herpesvirus humanos na mucosa oral de pacientes irradiados para tratamento de carcinoma epidermoide em região de cabeça e pescoço

“…O HHV-6 é o agente etiológico do exantema súbito, enquanto a infecção por HHV-7 é geralmente assintomática (Ward et al, 2005;Pinheiro et al, 2013). A taxa de excreção oral do HHV-6 na população geral é baixa, girando em torno de 10% (Biganzoli et al, 2010;Magalhães et al, 2010).…”