Features to validate cerebral toxoplasmosis

Abstract

Introduction: Neurotoxoplasmosis (NT) sometimes manifests unusual characteristics. Methods: We analyzed 85 patients with NT and AIDS according to clinical, cerebrospinal fl uid, cranial magnetic resonance, and polymerase chain reaction (PCR) characteristics. Results: In 8.5%, focal neurological defi cits were absent and 16.4% had single cerebral lesions. Increased sensitivity of PCR for Toxoplasma gondii DNA in the central nervous system was associated with pleocytosis and presence of >4 encephalic lesions. Conclusions: Patients with NT may present without focal neurological defi cit and NT may occur with presence of a single cerebral lesion. Greater numbers of lesions and greater cellularity in cerebrospinal fl uid improve the sensitivity of PCR to T gondii.

Diagnóstico diferencial de lesiones cerebrales con realce en anillo en tomografía computarizada y resonancia magnética

“…Sin embargo, rara vez se presentan en conjunto 9 . Pueden aparecer convulsiones tónico-clónicas, cefalea, hemiparesias, síndrome motor deficitario, síndrome cerebeloso, alteraciones de la memoria y la concentración, déficit focales en pares craneales; todos dependientes del número y localización de lesiones en el SNC 11 . El método de diagnóstico definitivo, se basa en estudios imagenológicos con TC y RM, asociado a hallazgos serológicos y Biopsia 12 .…”