Cacipacore virus as an emergent mosquito-borne Flavivirus

Abstract

Introduction:Cacipacore virus (CPCV), a possible bird-associated flavivirus, has yet to be detected in mosquitoes. Our purpose is examining CPCV in mosquitoes from the Amazon region of Brazil. Methods: Approximately 3,253 Culicidae (grouped into 264 pools) were collected from the Amazon region during 2002-2006 and analyzed using a Flavivirus genus-specific reverse transcription-polymerase chain reaction followed by nested polymerase chain reaction assay and by nucleotide sequencing of amplicons. Results: Nucleotide sequences from five mosquito samples showed high similarity to the those of CPCV originally isolated in the Amazon region. Conclusions: This is the first report of CPCV-infected mosquitoes which has implications on the arbovirus maintenance in nature and transmission to man.

Isolation of Flaviviruses and Alphaviruses with Encephalitogenic Potential Diagnosed by Evandro Chagas Institute in the Period of 1954–2022: Six Decades of Discoveries

“…The presence of antibodies against this arbovirus was detected in freeliving monkeys captured in the state of Mato Grosso do Sul, with two animals showing antibodies against flaviviruses and one showing a monotypic reaction against CACV. More recent studies reported the isolation of CACV from mosquitoes collected in the Amazon region and from human blood in the state of Rondônia [88,89].…”