Prevalence of low bone mass and changes in vitamin D levels in human immunodeficiency virus-infected adults unexposed to antiretrovirals

Abstract

Introduction: The prevalence of low bone mass is 3 times higher in people living with human immunodeficiency virus (PLWH) and using antiretrovirals than in the HIV-unaffected population. Changes in vitamin D levels is one of the factors associated with decreased bone mass. The objective of this study is to evaluate the low bone mass and altered vitamin D levels in PLWH who have not been exposed to antiretrovirals. Methods: A cross-sectional study was carried out with HIV-infected individuals between the ages of 18 and 55 years immediately prior to the start of antiretroviral therapy in a specialized reference center focusing on infectious and parasitic diseases. Results of clinical examination (patient's weight, height, blood pressure, and clinical history), laboratory tests, and X-ray absorptiometry, were collected. Results: Sixty patients were included, with a mean age of 34 years. Nine (16.7%) patients presented with low bone mass and 4 (7.1%) patients showed low total femur BMD. Analysis revealed that 23.3% and 36.7% of the patients had deficient and insufficient levels of 25-hydroxyvitamin D3, respectively. Conclusions: Our study population presented with compromised bone health and with low bone mineral density and 25-(OH)-vitamin D levels.

Vitamin D and Hemostasis Parameters in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Patients with Pulmonary Tuberculosis Coinfections

“…Vitamin D concentration within the body is affected by general factors, including genetics, exposure to ultraviolet light, skin color, culture, seasons, as well as latitude [8]. Inflammation may interfere with renal hydroxylation, leading to a decrease in Vitamin D concentration [9].…”