In vitro and in vivo antileishmanial activity of Artemisia annua L. leaf powder and its potential usefulness in the treatment of uncomplicated cutaneous leishmaniasis in humans

Mesa, Luz Estella; Vásquez, Daniel; Lutgen, Pierre; Vélez, Iván Darío; Restrepo, Alejandro Estrada; Ortiz, I.; Robledo, Sara M.

doi:10.1590/0037-8682-0457-2016

Cited by 30 publications

(18 citation statements)

References 26 publications

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“…The disease is a disfiguring skin lesion caused by distinct species of the Leishmania parasites and the aetiologic agents of Old World CL include Leishmania tropica , Leishmania major , Leishmania aethiopica , as well as Leishmania infantum . Cutaneous leishmaniasis is a complex disease observed in humans, caused by the Leishmania parasites, which spreads via female sandfly bites.…”

Section: Introductionmentioning

confidence: 99%

Arginase activity of Leishmania isolated from patients with cutaneous leishmaniasis

Badirzadeh

Taheri

Abedi-Astaneh

et al. 2017

Parasite Immunology

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Cutaneous leishmaniasis (CL) is one of the most important vector-borne parasitic diseases, highly endemic in Iran, and its prevalence is increasing all over the country. Arginase (ARG) activity in isolated Leishmania parasites from CL patients is yet to be explored. This study aimed to compare the ARG activity of isolated Leishmania promastigotes from CL patients with a standard strain of Leishmania major and its influences on the disease pathogenesis. We recruited 16 confirmed CL patients from Qom Province, in central Iran; after detection of Leishmania species using PCR-RFLP, we assessed the levels of ARG in the isolated promastigotes and determined the parasites' growth rate. Only L. major was identified from CL patients. The level of ARG activity in the isolated Leishmania promastigotes from CL patients was significantly higher than that obtained from the standard strain of L. major. No significant correlations between ARG activity and lesion size, number or duration were observed; in contrast, a significant negative correlation was seen between ARG level and Leishmania' growth rate. The obtained results suggest that increased ARG expression and activity in the isolated Leishmania promastigotes might contribute to the higher parasite infectivity and play a major role in the pathogenicity of the CL.

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Section: Introductionmentioning

confidence: 99%

Arginase activity of Leishmania isolated from patients with cutaneous leishmaniasis

Badirzadeh

Taheri

Abedi-Astaneh

et al. 2017

Parasite Immunology

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“…In vivo antileishmanial effects of Pistacia khinjuk (Anacardiaceae) alcoholic extract on Leishmania tropica and Leishmania major was shown by Ezatpour et al The extract increased NO production (17). In another study in vivo potential effectiveness of Artemisia annua against Leishmania was reported (23). The methanolic extract from the leaves of the Vietnamese medicinal plant Maesa balansae displayed effective in vivo activity against Leishmania infantum with 90% reduction of liver amastigote burden (24).…”

Section: In Vivo Herbal Therapymentioning

confidence: 96%

Herbal Drugs with Promising Anti-Leishmanial Activity: New Hope for Leishmaniasis Treatment

et al. 2016

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Context: Leishmaniasis is one of the most common parasitic diseases. Many medicinal plants have been utilized for the treatment of leishmaniasis. Evidence Acquisition: Recent clinical trials have proven the efficacy of a number of herbal drugs. Synthetic agents and current drugs on the market have some disadvantages, such as side effects, high cost, and painful injections. Given the efficiency of herbal drugs, they can be a source of natural and harmless compounds for Leishmania treatment. Results: Several researches have shown a wide range of plant extract exhibiting remarkable anti-leishmanial activity in vitro and in vivo. Conclusions: Attempts for discovery of an effective strategy for leishmaniasis treatment with nominal side effects are being continued and herbal drugs are receiving much interest. More clinical studies should be done to investigate the efficacy and safety of herbal drugs for the production of effective and safe drugs for leishmaniasis treatment. This may also provide new hope for leishmaniasis treatment.

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“…Artemisia plants have shown a remarkable effect against several tropical diseases: malaria, schistosomiasis, Chagas, leishmaniasis. [1][2][3][4][5][6][7] Considering all these data it would not be surprising to find that these diseases and Artemisia plants also have an effect on some metabolic and bodily functions. 8 Epidemiological links between malaria parasitaemia and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Artemisia afra and hypertension

Lutgen¹

2019

PPIJ

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In vitro and in vivo antileishmanial activity of Artemisia annua L. leaf powder and its potential usefulness in the treatment of uncomplicated cutaneous leishmaniasis in humans

Cited by 30 publications

References 26 publications

Arginase activity of Leishmania isolated from patients with cutaneous leishmaniasis

Arginase activity of Leishmania isolated from patients with cutaneous leishmaniasis

Herbal Drugs with Promising Anti-Leishmanial Activity: New Hope for Leishmaniasis Treatment

Artemisia afra and hypertension

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