Spatial analysis of viral hepatitis and schistosomiasis coinfection in an endemic area in Northeastern Brazil

Santos, Márcio Bezerra; Santos, Allan Dantas dos; Silva, Patrícia Pereira da; Barreto, Aline Silva; Santos, Erlon Oliveira dos; França, Alex Vianey Callado; Barbosa, Constança Simões; Araújo, Karina Conceição Gomes Machado de

doi:10.1590/0037-8682-0411-2016

Cited by 14 publications

(13 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The analysis of spatial distribution patterns indicated a higher concentration of cases and hospital admissions for schistosomiasis in areas along the coast of the states of Pernambuco, Alagoas, and Sergipe, corroborating other studies that revealed high morbidity and mortality rates due to the disease and the formation of clusters in these areas [30,[45][46][47][48]. Hospital admissions due to schistosomiasis result from the evolution of the disease, when there were failures in the identification of cases, timely treatment, and healthcare of the affected person [8].…”

Section: Discussionsupporting

confidence: 87%

Persistence of Schistosomiasis-Related Morbidity in Northeast Brazil: An Integrated Spatio-Temporal Analysis

Silva

Ferreira

Silva³

et al. 2021

TropicalMed

View full text Add to dashboard Cite

Objective: To analyze the temporal trend and spatial patterns of schistosomiasis-related morbidity in Northeast Brazil, 2001–2017. Methods: Ecological study, of time series and spatial analysis, based on case notifications and hospital admission data, as provided by the Ministry of Health. Results: Of a total of 15,574,392 parasitological stool examinations, 941,961 (6.0%) were positive, mainly on the coastline of Pernambuco, Alagoas and Sergipe states. There was a reduction from 7.4% (2002) to 3.9% (2017) of positive samples and in the temporal trend of the detection rate (APC—11.6*; Confidence Interval 95%—13.9 to −9.1). There was a total of 5879 hospital admissions, with 40.4% in Pernambuco state. The hospitalization rate reduced from 0.82 (2001) to 0.02 (2017) per 100,000 inhabitants. Conclusion: Despite the reduction in case detection and hospitalizations, the persistence of focal areas of the disease in coastal areas is recognized. This reduction may indicate a possible positive impact of control on epidemiological patterns, but also operational issues related to access to healthcare and the development of surveillance and control actions in the Unified Health System.

show abstract

Section: Discussionsupporting

confidence: 87%

Persistence of Schistosomiasis-Related Morbidity in Northeast Brazil: An Integrated Spatio-Temporal Analysis

Silva

Ferreira

Silva³

et al. 2021

TropicalMed

View full text Add to dashboard Cite

show abstract

“…In addition to promoting the maintenance of the parasite's transmission cycle, these conditions cause delays in the diagnosis and timely treatment of ill patients. As a result, there is a higher risk for the occurrence of severe clinical forms, as the chronic hepatosplenic form, and death [ 12 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, we observed a high number of infectious diseases as associated causes to schistosomiasis, mainly viral hepatitis, septicemia, and pneumonia. Prior studies have investigated the association between schistosomiasis and hepatitis caused by viruses B and C, especially in Egypt and Brazil [ 12 , 30 - 32 ]. The authors emphasize that the occurrence of both infections can further aggravate the patient's clinical condition, with a greater risk of liver fibrosis, portal hypertension, and the progression of hepatic fibrosis into cirrhosis and hepatocellular carcinoma, which considerably increases the risk of death [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…In that regard, temporal and spatial analysis techniques are one of the most efficient methods, since they allow to monitor the impacts of the disease over time and in space [ 9 , 11 ]. Several studies have used spatial and spatiotemporal analysis tools to comprehend the dynamics of schistosomiasis in Brazil [ 4 , 6 , 12 ]. Nevertheless, there are no studies investigating the associated causes of death from the disease at the national level.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Basic and associated causes of schistosomiasis-related mortality in Brazil: A population-based study and a 20-year time series of a disease still neglected

et al. 2021

View full text Add to dashboard Cite

Background Schistosomiasis is a persistent public health problem in Brazil. Regardless advances in diagnosis and mass treatment, schistosomiasis has a severe impact on morbimortality in the country and remains a neglected tropical disease. Herein, we assessed the basic and associated causes of schistosomiasis-related deaths and the temporal and spatial patterns of mortality from the disease in Brazil between 1999 and 2018. Methods We conducted an ecological and time series study. The segmented log-linear regression model was applied to assess time trends, considering all deaths recorded in the category B65/ICD-10. Additionally, we elaborated maps of mortality rates from schistosomiasis in Brazil. Results A total of 4168 schistosomiasis-related deaths were recorded in Brazil in this period, as an associated cause. Time trend analysis revealed an increase in the average age of deaths from schistosomiasis (annual percentage change (APC) = 0.84), and stable trend in Brazil (APC = 0.31). Concerning schistosomiasis-related deaths, we observed disorders related to the digestive system, liver diseases, septicemias, and chronic diseases. Surprisingly, there were deaths caused by non-endemic Schistosoma species in Brazil. Also, municipalities from non-endemic areas in Brazil presented schistosomiasis-related deaths. Conclusion Altogether, our analyses demonstrated that schistosomiasis remains a significant cause of death in Brazil, and it is increasing in some areas, especially in the Northeast region. Additionally, women and the elderly showed a stable time trend of deaths. Thereby, it urgently requires improvements in the control programs strategies, in the sense of an effective reduction in cases and deaths from the disease in Brazil.

show abstract

“…Schistosoma mansoni is the species causing human schistosomiasis in Brazil. Schistosomiasis is endemic in 19 of the 27 states in Brazil with over 70% of cases from the Northeast region 2 . An estimated 1.5 million individuals were infected with S. mansoni and 42.9 million people were at high risk of infection 3 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of schistosomula crude antigen (SCA) as a diagnostic tool for Schistosoma mansoni in low endemic human population

Oyeyemi

Corsini

Gonçalves

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The study aimed to determine the potential of schistosomula crude antigen (SCA) as a diagnostic target for anti-S. mansoni antibody detection. Cercariae were transformed into schistosomula, homogenized through sonication, and then centrifuged to obtain the SCA. SCA was evaluated using ELISA and dot blots immunoassays on 30 S. mansoni infected sera samples obtained from chronic patients and 30 non-infected humans’ sera samples. Either Kato-Katz or saline gradient method or both were employed as the diagnostic reference. Dot blots immunoassay was further performed on protein eluted from 10 to 12 kDa immunoreactive band identified by Western blot analysis. The area under the ROC curve was 0.95 (AUC 0.95, CI 0.88–1.01, p < 0.0001). The sensitivity and specificity of SCA-ELISA and dot blots assays were 96.67% and 86.67% respectively. The human IgG-specific response against SCA was significantly higher in S. mansoni infected individuals (OD = 0.678 ± 0.249) compared to the non-infected population (OD = 0.235 ± 0.136) (p < 0.0001). Our study showed that SCA and its 10–12 kDa component could be useful as diagnostic tools for chronic schistosomiasis.

show abstract

Spatial analysis of viral hepatitis and schistosomiasis coinfection in an endemic area in Northeastern Brazil

Abstract: Spatial analysis allowed visualization of high-risk areas, leading to a definition of priority areas to be targeted for intensification of control interventions.

Cited by 14 publications

References 11 publications

Persistence of Schistosomiasis-Related Morbidity in Northeast Brazil: An Integrated Spatio-Temporal Analysis

Persistence of Schistosomiasis-Related Morbidity in Northeast Brazil: An Integrated Spatio-Temporal Analysis

Basic and associated causes of schistosomiasis-related mortality in Brazil: A population-based study and a 20-year time series of a disease still neglected

Evaluation of schistosomula crude antigen (SCA) as a diagnostic tool for Schistosoma mansoni in low endemic human population

Contact Info

Product

Resources

About