Guidelines for the management of human brucellosis in the State of Paraná, Brazil

Tuon, Felipe Francisco; Cerchiari, Natacha; Cequinel, Juliana Clelia; Droppa, Elizabeth El Hajjar; Moreira, Suzana Dal Ri; Costa, Tânia Portella; Navarro, Amanda de Paula Boni; Handar, Antonieta Milleo; Souza, Margely Nunes de

doi:10.1590/0037-8682-0319-2016

Cited by 23 publications

(27 citation statements)

References 23 publications

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“…Furthermore, the monotherapy for brucellosis has been considered inadequate due to unacceptably high relapse rates, now we present possible treatment schemes [2,3].…”

Section: Antibiotic Treatmentmentioning

confidence: 99%

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Update of Antibiotic Therapy of Brucellosis

Villate¹,

Casallas²

2020

New Insight Into Brucella Infection and Foodborne Diseases

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Currently, the only option for treating brucellosis is antibiotics especially to prevent complications. In this chapter, we want to talk about the drug therapy in brucellosis and the update of these therapies in the last years. Also, we will expose the principal antibiotics in brucellosis such as doxycycline, rifampin, streptomycin, cotrimoxazole (TMP/SMX), and gentamicin by talking about each one of their mechanism of action, pharmacokinetics, administration, risk assessment, adverse effects, and principal drug interactions. Furthermore, we will add the evidence of efficacy therapy in monotherapy or combinate therapy based on the evidence.

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“…Furthermore, the monotherapy for brucellosis has been considered inadequate due to unacceptably high relapse rates, now we present possible treatment schemes [2,3].…”

Section: Antibiotic Treatmentmentioning

confidence: 99%

“…• Doxycycline 100 mg orally twice daily plus rifampin 600-900 mg (15 mg/kg) orally one daily for 6 weeks [1,3].…”

Section: Antibiotic Treatmentmentioning

confidence: 99%

Update of Antibiotic Therapy of Brucellosis

Villate¹,

Casallas²

2020

New Insight Into Brucella Infection and Foodborne Diseases

View full text Add to dashboard Cite

show abstract

“…Brucella spp. is a Gram-negative coccobacillus that causes Brucellosis (also known as “Malta fever”); a contagious zoonotic infectious disease (1). The genus Brucella consists of seven species, four of which causes a disease in humans.…”

Section: Introductionmentioning

confidence: 99%

“…To aid the clinical diagnosis of brucellosis, laboratory methods are utilized which include direct and indirect methods. Direct methods include microbiological culturing as well as the detection Brucella gene using polymerase chain reaction (PCR) test (1). Brucella culture is considered the gold standard and provides the definitive diagnosis of the disease (5).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, indirect serological assays are used alternatively and provide faster results. The Rose Bengal testing, tube agglutination, and enzyme-linked immunosorbent assay (ELISA) are the most recommended methods of Brucella serology (1). Moreover, some nonspecific laboratory tests, such as white blood cell (WBC) count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum lactate dehydrogenase, and alkaline phosphatase may show some changes (6).…”

Section: Introductionmentioning

confidence: 99%

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