The effectiveness of a rotavirus vaccine in preventing hospitalizations and deaths presumably due to acute infectious diarrhea in Brazilian children: a quasi-experimental study

Teles, Estêvão; Moscovici, Leonardo; Monteiro, Rosane Aparecida; Alves, Domingos; Laprega, Milton Roberto; Bellissimo-Rodrigues, Fernando

doi:10.1590/0037-8682-0311-2014

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Several studies have indicated that rotavirus vaccination programs are a high‐impact intervention for public health [Vesikari et al, ; Leshem et al, ; Paternina‐Caicedo et al, ; Atchison et al, ]. Specifically, in every Latin American and the Caribbean country where rotavirus vaccine was massively introduced, reduction of the severity and cases of death related to this agent was observed [Molto et al, ; Patel et al, ; Rha et al, ; de Oliveira et al, ; Paternina‐Caicedo et al, ; Teles et al, ]. As national analyses have already revealed, routine vaccination against rotavirus is considered highly cost‐effective and even cost‐saving in the North region [Urueña et al, ].…”

Section: Discussionmentioning

confidence: 99%

Rotavirus epidemiology and surveillance before vaccine introduction in Argentina, 2012–2014

Degiuseppe

Reale

Stupka

2016

Journal of Medical Virology

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Group A Rotavirus has been widely described as one of the most important infantile diarrheal pathogens worldwide. In Argentina, it is responsible for over 200,000 acute diarrhea cases and from 30 to 50 deaths annually in children under 5 years. The aim of this study is to analyze frequency, seasonality, age group distribution, and circulating genotypes based on data notified in the 2012-2014 period and in turn to assess the pre-vaccine scenario, considering that rotavirus vaccine was introduced in 2015. Data were taken from the Viral Diarrhea Notification module of the Argentine SNVS-SIVILA surveillance tool. Analyses of circulating genotypes were performed on rotavirus-positive stool specimens by conventional binary characterization of the outermost capsid genes. Overall data showed rotavirus detection in about 25% of samples tested, and higher rates in children under 2 years old were observed. Rotavirus positive cases were distributed according to a typical winter seasonal pattern. A heterogeneous regional pattern of prevalence was also observed, with higher rates detected in the North region. Genotype co-circulation and annual fluctuation were observed. In general, G1P[8], G2P[4], G3P[8], and G12P[8] were the most frequently detected genotypes. This study represents the last survey taken of a population considered to be naïve. J. Med. Virol. 89:423-428, 2017. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Rotavirus epidemiology and surveillance before vaccine introduction in Argentina, 2012–2014

Degiuseppe

Reale

Stupka

2016

Journal of Medical Virology

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“…In Brazil, the reduction ranged from 17 to 21.4%; 12,20 in the South and Southeast region, the reduction was 35% in the year 2007; 21 in the Southeast region the reduction was 21%; 12 and in the State of São Paulo the reduction ranged from 21 to 40%. 13,22 In the peak period of rotavirus infection (May and June), the reduction in hospital admissions due to acute diarrhea after the introduction of the vaccine was 82%, suggesting that the effectiveness of the vaccine was good. This result is compatible with efficacy studies conducted in Europe and Latin America, where the efficacy of the vaccine against hospital admissions ranged from 85 to 96%.…”

Section: Discussionmentioning

confidence: 99%

The impact of rotavirus vaccination on emergency department visits and hospital admissions for acute diarrhea in children under 5 years

Paulo

Rodrigues²,

Machado

et al. 2016

Rev. Assoc. Med. Bras.

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We screened the main diagnosis of all ED attendances and hospital admissions of children under 5 years in an electronic registry system database and calculated the rates of ED visits and hospital admissions. The reduction rate was analyzed according to the following formula: reduction (%) = (1 -odds ratio) x 100. Results: The rates of ED visits for acute diarrhea was 85.8 and 80.9 per 1,000 total ED visits in the pre and post vaccination periods, respectively, resulting in 6% reduction (95CI 4 to 9%, p<0.001). The rates of hospital admissions for acute diarrhea was 40.8 per 1,000 in the pre-vaccine period and dropped to 24.9 per 1,000 hospitalizations, resulting in 40% reduction (95CI 22 to 54%, p<0.001). Conclusion:The introduction of the RV1 vaccine resulted in 6% reduction in the ED visits and 40% reduction in hospital admissions for acute diarrhea.

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“…As restrições de idade utilizadas para aplicação de doses são uma precaução devido ao risco aumentado de eventos adversos pós-vacinação encontrado em estudos envolvendo as primeiras vacinas Rotavírus (WHO, 2013a). Estudos já mostraram que após a introdução da vacina no Brasil, em meados de 2006, houve queda de hospitalizações e da mortalidade causadas por diarreia relacionada a rotavírus e reforçam a importância do alcance de coberturas cada vez mais próximas de 100% (do CARMO et al, 2011;DULGHEROFF et al, 2012;LUCHS et al, 2015;TELES et al, 2015;MASUKAWA et al, 2015), porém é importante observar o risco de casos de intussuscepção que, apesar de menor com as novas vacinas, segue sendo um importante evento adverso.…”

Section: Coberturas Específicasunclassified

Avaliação de coberturas vacinais aos 12 e 24 meses de idade por meio de um sistema informatizado de imunização em Araraquara (SP)

Ferreira¹

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pela oportunidade, acolhimento, atenção, paciência, ensinamentos, confiança e incentivos durante esses dois anos. À Profª Drª Patricia Constante Jaime, pelo apoio desde os tempos de graduação, pelo exemplo como profissional e por despertar em mim o interesse pela pesquisa.À Profª Drª Maria do Rosário Dias de Oliveira Latorre, pelos ensinamentos durante os dois anos de iniciação científica, os quais me deram certeza de que deveria seguir a carreira acadêmica.À equipe do Registro de Câncer de Base Populacional de São Paulo durante meu período como aluno de iniciação científica, pela colaboração e pela amizade. À Fernanda Michels e Stela Verzinhasse, pelos grandes ensinamentos, apoio e amizade.Ao Prof. Dr. Marcelo Macedo Rogero, pelos ensinamentos, conselhos e apoio durante a graduação e o mestrado.Ao Prof. Dr. Wolney Lisboa Conde, pelos ensinamentos durante minha primeira etapa do mestrado.

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The effectiveness of a rotavirus vaccine in preventing hospitalizations and deaths presumably due to acute infectious diarrhea in Brazilian children: a quasi-experimental study

Cited by 6 publications

References 23 publications

Rotavirus epidemiology and surveillance before vaccine introduction in Argentina, 2012–2014

Rotavirus epidemiology and surveillance before vaccine introduction in Argentina, 2012–2014

The impact of rotavirus vaccination on emergency department visits and hospital admissions for acute diarrhea in children under 5 years

Avaliação de coberturas vacinais aos 12 e 24 meses de idade por meio de um sistema informatizado de imunização em Araraquara (SP)

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