The deadliest snake according to ethnobiological perception of the population of the Alto Juruá region, western Brazilian Amazonia

Silva, Jessyca Lima da; Siva, Ageane Mota da; Amaral, Gardênia Lima Gurgel do; Ortega, Givanildo Pereira; Monteiro, Wuelton Marcelo; Bernarde, Paulo Sérgio

doi:10.1590/0037-8682-0305-2019

Cited by 12 publications

(4 citation statements)

References 15 publications

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“…The grade of envenoming is assessed according to the conclusions of the international symposium held in French Guiana in 2017 [ 5 ]. Adverse reactions to antivenom were reported to the French Agency for the Safety of Health Products (ANSM: Agence Nationale de Sécurité de Médicaments) and were classified as ‘mild’ (only cutaneous-urticaria, pruritus) or ‘severe’ (bronchospasm, angioedema, hypotension, colic) [ 38 ].…”

Section: Methodsmentioning

confidence: 99%

Clinical Features and Management of Snakebite Envenoming in French Guiana

Résière

Houcke

Pujo

et al. 2020

Toxins

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The management of snakebite (SB) envenoming in French Guiana (FG) is based on symptomatic measures and antivenom (AV) administration (Antivipmyn Tri®; Instituto Bioclon—Mexico). Our study aimed to assess clinical manifestations, the efficacy, and safety of Antivipmyn Tri® in the management of SB. Our study is a prospective observational work. It was conducted in the Intensive Care Unit (ICU) of Cayenne General Hospital between January 1st, 2016 and December 31, 2019. We included all patients hospitalized for SB envenoming. Our study contained three groups (without AV, three vials, and six vials Antivipmyn Tri®). During the study period, 133 patients were included. The main clinical symptoms were edema (98.5%), pain (97.7%), systemic hemorrhage (18%), blister (14.3%), and local hemorrhage (14.3%). AV was prescribed for 83 patients (62.3%), and 17 of them (20%) developed early adverse reactions. Biological parameters at admission showed defibrinogenation in 124 cases (93.2%), International Normalized Ratio (INR) > 2 in 104 cases (78.2%), and partial thromboplastin time (PTT) > 1.5 in 74 cases (55.6%). The time from SB to AV was 9:00 (5:22–20:40). The median time from SB to achieve a normal dosage of fibrinogen was 47:00 vs. 25:30, that of Factor II was 24:55 vs. 15:10, that of Factor V was 31:42 vs. 19:42, and that of Factor VIII was 21:30 vs. 10:20 in patients without and with AV, respectively, (p < 0.001 for all factors). Patients receiving Antivipmyn Tri® showed a reduction in the time to return to normal clotting tests, as compared to those who did not. We suggest assessing other antivenoms available in the region to compare their efficacy and safety with Antivipmyn Tri® in FG.

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Section: Methodsmentioning

confidence: 99%

Clinical Features and Management of Snakebite Envenoming in French Guiana

Résière

Houcke

Pujo

et al. 2020

Toxins

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“…An estimated 30,000 SBE incidents occur every year in this country resulting in approximately 4000 deaths ( Schneider et al, 2021 ). Most SBE incidents are caused by snakes of the Crotalus , Lachesis , Micrurus , and Bothrops genera although Bothrops species (lanceheads) cause more incidents than the others since they are found throughout Brazil ( Silva et al, 2019 ). The Ministry of Health in Brazil is responsible for managing SBE in the country, including the distribution of antivenom to main hospitals free of charge.…”

Section: Sbe In India and Brazilmentioning

confidence: 99%

Multifaceted community health education programs as powerful tools to mitigate snakebite-induced deaths, disabilities, and socioeconomic burden

Vaiyapuri

Kadam²,

Chandrasekharuni

et al. 2023

Toxicon: X

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“…In Brazil, snakebites are mainly associated with agricultural work and, in the Amazon region, also with extractive activities ( Silva et al, 2020 ; Feitosa et al, 2015 ; Pierini et al, 1996 ; Waldez and Vogt, 2009 ). Approximately 29,000 cases of snakebite accidents are reported each year by the SINAN (Reporting Disease Information System), with an average of 129 yearly deaths (0.44% lethality) ( Bernarde, 2014 ).…”

Section: Lachesis Envenoming: Epidemiology Symptoms and Treatmentmentioning

confidence: 99%

A brief review on the natural history, venomics and the medical importance of bushmaster (Lachesis) pit viper snakes

et al. 2020

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Snakes of the genus Lachesis , commonly known as bushmasters, are the largest venomous snakes in the Americas. Because these snakes have their habitats in areas of remote forests they are difficult to find, and consequently there are few studies of Lachesis taxa in their natural ecosystems. Bushmasters are distributed in tropical forest areas of South and Central America. In Brazil they can be found in the Amazon Rainforest and the Atlantic Forest. Despite the low incidence of cases, laquetic envenoming causes severe permanent sequelae due to the high amount of inoculated venom. These accidents are characterized by local pain, hemorrhage and myonecrosis that can be confused with bothropic envenomings. However, victims of Lachesis bites develop symptoms characteristic of Lachesis envenoming, known as vagal syndrome. An important message of this bibliographic synthesis exercise is that, despite having the proteomic profiles of all the taxa of the genus available, very few structure-function correlation studies have been carried out. Therefore the motivation for this review was to fill a gap in the literature on the genus Lachesis , about which there is no recent review. Here we discuss data scattered in a number of original articles published in specialized journals, spanning the evolutionary history and extant phylogeographic distribution of the bushmasters, their venom composition and diet, as well as the pathophysiology of their bites to humans and the biological activities and possible biotechnological applicability of their venom toxins.

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The deadliest snake according to ethnobiological perception of the population of the Alto Juruá region, western Brazilian Amazonia

Cited by 12 publications

References 15 publications

Clinical Features and Management of Snakebite Envenoming in French Guiana

Clinical Features and Management of Snakebite Envenoming in French Guiana

Multifaceted community health education programs as powerful tools to mitigate snakebite-induced deaths, disabilities, and socioeconomic burden

A brief review on the natural history, venomics and the medical importance of bushmaster (Lachesis) pit viper snakes

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