Impact of the coronavirus disease 2019 on the diagnoses of Hansen's disease in Brazil

Marques, Nelson Pereira; Marques, Nádia Carolina Teixeira; Cardozo, Iberto Medeiros; Martelli, Daniella Reis Barbosa; Lucena, Edson Hilan Gomes de; Oliveira, Eduardo A.; Martelli, Hercílio

doi:10.1590/0037-8682-0251-2021

Cited by 8 publications

(7 citation statements)

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“…Hansen's disease control in Brazil is also threatened by a precipitous fall in new case detection rates, estimated to be almost 50% nationally when comparing the average number of newly diagnosed cases in 2010–2019 with 2020, representing almost 20,000 missed cases even before taking into account cases missed during 2021. 21 …”

Section: Discussionmentioning

confidence: 99%

“…Treatment adherence and cure among multibacillary patients was positively associated with receipt of the Programa Bolsa Família (PBF), 19 a Brazilian conditional cash transfer program which has been threatened by the financial and political fallout arising from the pandemic. Hansen's disease control in Brazil is also threatened by a precipitous fall in new case detection rates, estimated to be almost 50% nationally when comparing the average number of newly diagnosed cases in 2010–2019 with 2020, representing almost 20,000 missed cases even before taking into account cases missed during 2021 21 …”

Section: Discussionmentioning

confidence: 99%

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Hansen's disease and COVID‐19 co‐infection in Brazil

et al. 2022

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Background The implications of COVID‐19 co‐infection in patients under treatment for Hansen's disease (HD, leprosy) remain uncertain. We aimed to describe clinical characteristics, treatments, and outcomes in patients with HD and COVID‐19 in Brazil. Methods Cross‐sectional study recruiting adult HD patients with PCR‐confirmed COVID‐19 from five HD treatment centers in Brazil between March 1, 2020, and March 31, 2021. At the time of this study, no patient had received COVID‐19 vaccine. Results Of 1377 patients under treatment for HD, 70 (5.1%) were diagnosed with COVID‐19. Of these, 41 (58.6%) had PCR‐confirmed COVID‐19, comprising 19 men and 22 women, aged 24–67 (median 45) years. HD was multibacillary in 39/41 patients. Eight patients ceased WHO Multi‐Drug Therapy for HD, three for lack of drugs, two because of COVID‐19, and three for other reasons. Of the 33 who continued treatment, 26 were on the standard regimen and seven an alternative regimen. Seventeen patients were receiving oral prednisone, including nine patients with type 1 reaction, four with type 2 reaction, three with neuritis, and one with rheumatologic disease. Twelve patients were hospitalized for COVID‐19, and six patients died, of whom three had hypertension and one also had type 2 diabetes and obesity. Conclusions COVID‐19 and Hansen's disease co‐infection did not appear to change the clinical picture of either disease in this cross‐sectional study. The wider impact of the pandemic on persons affected by HD requires follow‐up and monitoring.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Hansen's disease and COVID‐19 co‐infection in Brazil

et al. 2022

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“…A apuração do número de casos de hanseníase no Brasil, diagnosticados entre 2010 e 2020, demonstrou que houve redução no número de diagnósticos entre 2010 e 2015, seguido por uma estabilização nos anos subsequentes e uma queda considerável no ano de 2020 (Marques et al, 2021). Nesse ano, com o aumento do número de casos da COVID-19 durante a pandemia, todos os estados brasileiros apresentaram queda no diagnóstico da hanseníase, como na região Nordeste, que apresentou diminuição de 44,40% entre 2019-2020, mas aumento no número de casos multibacilares e pessoas incapacitadas pela doença (Matos et al, 2021).…”

Section: Discussionunclassified

Impacto da pandemia de COVID-19 no cuidado continuado da hanseníase: uma revisão integrativa

Reis

Oliveira²,

Gomes³

et al. 2022

RSD

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A hanseníase é uma doença infecciosa que necessita de cuidados continuados para sua cura completa. Pacientes com essa e outras doenças crônicas apresentaram barreiras na longitudinalidade do tratamento com a pandemia do novo coronavírus. O objetivo deste artigo foi avaliar qual o impacto da pandemia de COVID-19 no cuidado continuado ao mal de Hansen. Trata-se de uma revisão integrativa de aspecto exploratório-descritivo que pesquisou as palavras-chave “Hanseníase”, “Cuidados Continuados” e “COVID-19” conectadas pelo termo AND nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Sistema Online de Busca e Análise de Literatura Médica (MEDLINE) e Biblioteca Eletrônica Científica Online (SCIELO) por meio da Biblioteca Virtual em Saúde (BVS). Foram encontrados 55 artigos, dos quais, ao serem filtrados por critérios de inclusão e exclusão, foram escolhidos 07 estudos para a confecção final deste documento. Os resultados mostraram que houve subnotificação dos casos de hanseníase durante a crise do COVID-19 em decorrência das barreiras de acesso aos serviços de saúde, além de negligência a aspectos básicos do tratamento continuado do mal de Hansen, a saber: falta de disponibilidade de medicamentos, campanhas de conscientização e cursos de capacitação. Conclui-se que os setores governamentais necessitam elaborar planos para a manutenção do adequado cuidado à hanseníase mesmo em situações pandêmicas, pois a doença gera alta morbidade nesses pacientes, que necessitam de atenção e integralidade para a resolução dessa infecção crônica.

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“…Analysis of larger regions not limited to Yunnan Province could reveal the localized spatial and transmission characteristics of leprosy more comprehensively and accurately. In addition, analysis of statistics from 2020 would not reflect reality due to the impact of the coronavirus disease 2019 (COVID-19) pandemic that occurred during this period [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

The state of the leprosy epidemic in Yunnan, China 2011–2020: A spatial and spatiotemporal analysis, highlighting areas for intervention

Chen

Shui

2021

PLoS Negl Trop Dis

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Background Despite public health efforts to reduce the leprosy burden in Yunnan, China, leprosy remains an important public health problem in some specific areas. We analyzed the epidemiological characteristics and spatial distribution of leprosy in Yunnan, China, and provide data to guide disease prevention and control efforts. Methodology/principal findings The surveillance data of newly detected leprosy cases in Yunnan, China, during 2011–2020 were extracted from the LEPROSY MANAGEMANT INFORMATION SYSTEM IN CHINA (LEPMIS), and spatial distribution analysis, spatial autocorrelation analysis, and spatiotemporal scanning were performed with ArcGIS 10.6.1, GeoDa 1.8.8, and SaTScan 9.4.3 software, respectively. A total of 1907 newly detected leprosy cases were reported in Yunnan, China, during 2011–2020. The new case detection rate (NCDR) decreased from 0.62 in 2011 to 0.25 in 2020, with an annual incidence of 0.41/100,000 population. The proportions of multibacillary (MB) cases, cases in female patients, cases causing grade 2 physical disability (G2D), and cases in pediatric patients were 67.07%, 33.93%, 17.99%, and 2.83%, respectively. The number of counties with an incidence above 1/100,000 population decreased from 30 in 2011 to 8 in 2020. The Moran’s I of leprosy in Yunnan, China, during 2011–2020 ranged from 0.076 to 0.260, indicating the presence of spatial clusters. Local spatial autocorrelation (LSA) analysis showed that high-high cluster areas (hot spots) were mainly distributed in the southeastern, northern, and northwestern regions. Spatiotemporal scanning showed three clusters with high NCDRs. The probably primary clusters, occurring during January 1, 2011–December 31, 2015, covered 11 counties in the southeastern region (RR = 5.046515, LRR = 271.749664, P = 0.000). Conclusion The number of leprosy cases in Yunnan decreased overall, although some high-NCDR regions remained. Geographic information system (GIS) analysis coupled with spatial analysis indicated regions with leprosy clusters. Continuous leprosy prevention and control strategies in Yunnan Province should be established, and interventions in high-risk regions should be prioritized and further strengthened.

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Impact of the coronavirus disease 2019 on the diagnoses of Hansen's disease in Brazil

Cited by 8 publications

References 8 publications

Hansen's disease and COVID‐19 co‐infection in Brazil

Hansen's disease and COVID‐19 co‐infection in Brazil

Impacto da pandemia de COVID-19 no cuidado continuado da hanseníase: uma revisão integrativa

The state of the leprosy epidemic in Yunnan, China 2011–2020: A spatial and spatiotemporal analysis, highlighting areas for intervention

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