Detection of antibodies against Leptospira spp in free-living marsupials caught in the Eastern Amazon

Mesquita, Gleiciane Schupp de Sena; Rocha, Katarine de Souza; Monteiro, Thamillys Rayssa Marques; Rosário, Marcely Karen Santos do; Baia, Ianny Watuzy Monteiro; Pereira, Helyanne de Sousa; Cerqueira, Valíria Duarte; Moraes, Carla Cristina Guimarães de

doi:10.1590/0037-8682-0236-2017

Cited by 8 publications

(7 citation statements)

References 7 publications

(9 reference statements)

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“…had already been detected in D. marsupialis, Caluromys sp. and Marmosa murina in the same region in the state of Pará (Mesquita et al 2018), which, together with our detection of Leptospira DNA in kidney samples from D. marsupialis and M. pinheiroi, suggests that marsupials are potential reservoirs of the agent at the region. This is also the first report of infection by Leptospira spp.…”

Section: Palavras-chavesupporting

confidence: 69%

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New records of Leptospira spp. in wild marsupials and a rodent in the eastern Brazilian Amazon through PCR detection

et al. 2020

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We analyzed the presence of Leptospira spp. in liver and kidney tissue of wild marsupials and rodents trapped in a periurban forest in the eastern Brazilian Amazon. We examined 25 individuals of four marsupial and seven rodent species for the presence of the 16S rRNA gene of Leptospira in the DNA extracted from 47 liver and kidney tissue samples using PCR. We detected positive samples in 12% (3/25) of the individuals, in kidney fragments of two marsupial species (Didelphis marsupialis and Marmosops pinheiroi) and in a liver fragment of one rodent species (Echimys chrysurus). These are the first records of Leptospira spp. in M. pinheiroi and E. chrysurus and it is the first molecular survey of marsupials and rodents in the Brazilian Amazon.

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Section: Palavras-chavesupporting

confidence: 69%

“…and a marsupial (Didelphis marsupialis Linnaeus, 1758), and two unidentified isolates in rodents and four in marsupials. Mesquita et al (2018) reported a prevalence of 36.8% of seropositive D. marsupialis, Caluromys sp. and Marmosa murina (Linnaeus, 1758) for antibodies to serovars Icterohaemorrhagiae, Panama and Nupezo.…”

Section: Palavras-chavementioning

confidence: 99%

New records of Leptospira spp. in wild marsupials and a rodent in the eastern Brazilian Amazon through PCR detection

et al. 2020

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“…Other municipalities such as São Francisco do Pará, Ponta de Pedras, Breves, Bragança, Castanhal, and São Domingos do Capim, registered increased incidence, which demonstrates the need for greater State intervention in these regions. The recent detection of anti-leptospira antibodies in wild marsupials in the municipalities of Castanhal, Peixe-boi and Viseu, in the northeast mesoregion and the same mesoregion for some of the municipalities mentioned above, demonstrate a circulation of the pathogen amongst these animals, and this can be an important source of leptospirosis infection for inhabitants in this area 25 .…”

Section: Discussionmentioning

confidence: 88%

Spatio-temporal analysis of leptospirosis in Eastern Amazon, State of Pará, Brazil

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Oliveira

et al. 2020

Rev. bras. epidemiol.

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Introduction: Brazil has registered more than 62,000 confirmed cases of leptospirosis between 2001 and 2017, with more than 2,000 cases confirmed in the State of Pará. Despite a large number of cases, no study has been conducted to trace the spatio-temporal profile of the disease. Methodology: Confirmed cases of leptospirosis from 2001 to 2017 from the state of Pará were the basis for this space-time study. The database of the Department of Informatics of the Ministry of Health was used to access data on leptospirosis. The spatio-temporal analysis was performed in the SaTScan software for the detection of clusters, and maps were generated in the QGIS software. Results: The municipalities of Belém and Santarém were among the ones with the highest incidence rates of leptospirosis for the whole study period. Increased number of cases in Soure, Inhangapi, São João da Ponta and Magalhães Barata, Ponta de Pedras, Breves, Bragança, Castanhal, and São Domingos do Capim were identified in different time periods. Santarém and Belém are the main foci of leptospirosis because they are the most urbanized and densely populated municipalities in the State. The cases found in smaller municipalities may be associated with periods of more frequent rainfall and circulation of Leptospira sp. in marsupials and cattle, in the northeastern part of the State. Conclusion: Further studies are needed to help identify the risk factors that contribute to the occurrence of leptospirosis in the State of Pará, particularly in areas with lower population density.

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“…Rodents have been described as the most essential maintenance/amplifier reservoirs in nature for several pathogenic Leptospira (9,10). In Brazil, marsupials from the eastern Amazon (11), semi-arid regions (12), and the Atlantic Forest biome (13,14) have also been reported with antibodies against Leptospira spp. The first report of Leptospira isolation in samples of Didelphis albiventris was from southern Brazil.…”

Section: Introductionmentioning

confidence: 99%

Small Mammals as Carriers/Hosts of Leptospira spp. in the Western Amazon Forest

et al. 2020

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Leptospira is a bacteria that causes leptospirosis and is transmitted through water, soil, or mud that is contaminated by the urine of infected animals. Although it is mainly associated with the urban environment, Leptospires also circulate in rural and wild environments. This study aimed to investigate the role of small mammals in leptospirosis epidemiology in the western Amazon, Brazil. In total, 103 animals from 23 species belonging to the orders Didelphimorphia and Rodentia were captured. Blood, kidney, and urine samples were collected and Microscopic Agglutination Test (MAT), lipL32 PCR, secY sequencing, and culturing were conducted. MAT was reactive on 1/15 sera, and no bacterial isolate was obtained. PCR yielded 44.7% positive samples from 16 species. Twenty samples were genetically characterized and identified as L. interrogans (n = 12), L. noguchii (n = 4), and L. santarosai (n = 4). No statistical association was found between the prevalence of infection by Leptospira spp. in small mammals within carrier/hosts species, orders, study area, and forest strata. Our results indicate a high prevalence of pathogenic Leptospira spp. in several rodent and marsupial species and report the first evidence of Leptospira spp. carrier/hosts in the Brazilian Western Amazon.

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Detection of antibodies against Leptospira spp in free-living marsupials caught in the Eastern Amazon

Cited by 8 publications

References 7 publications

New records of Leptospira spp. in wild marsupials and a rodent in the eastern Brazilian Amazon through PCR detection

New records of Leptospira spp. in wild marsupials and a rodent in the eastern Brazilian Amazon through PCR detection

Spatio-temporal analysis of leptospirosis in Eastern Amazon, State of Pará, Brazil

Small Mammals as Carriers/Hosts of Leptospira spp. in the Western Amazon Forest

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