2017
DOI: 10.1590/0037-8682-0230-2017
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Abstract: Paracoccidioidomycosis is a systemic fungal disease occurring in Latin America that is associated with rural environments and agricultural activities. However, the incidence and prevalence of paracoccidiodomycosis is underestimated because of the lack of compulsory notification. If paracoccidiodomycosis is not diagnosed and treated early and adequately, the endemic fungal infection could result in serious sequelae. While the Paracoccidioides brasiliensis (P. brasiliensis) complex has been known to be the causa… Show more

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Cited by 289 publications
(585 citation statements)
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References 95 publications
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“…The mononuclear phagocytic system is the main site of infection. The lymph nodes are involved in nearly 100% of acute PCM cases, followed by the liver, spleen, and skin 1,6 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The mononuclear phagocytic system is the main site of infection. The lymph nodes are involved in nearly 100% of acute PCM cases, followed by the liver, spleen, and skin 1,6 .…”
Section: Discussionmentioning
confidence: 99%
“…These range from chronic PCM (adult type), accounting for 80-90% of cases that are mostly among male farm workers and usually affecting the lungs and oral mucosa, to acute/subacute PCM (juvenile type) in young susceptible patients presenting a more severe clinical condition because of intense reticuloendothelial system involvement 1 . Although it has been hypothesized that Paracoccidioides lutzii is associated with severe clinical forms, P. brasiliensis has also been recently reported to cause serious and unusual clinical pictures 2,3 .…”
Section: Introductionmentioning
confidence: 99%
“…Some patients have persistent pulmonary complications including residual pulmonary nodules (coccidioidomas), fibrosis and cavities, with the concurrent risks of developing chronic pulmonary aspergillosis or pulmonary abscesses, or fistulae as long-term sequelae [7,12,13]. dor, Peru, and Venezuela [14,15]. It is usually seen in individuals working in rural areas (e.g., farmers).…”
Section: Coccidioidomycosismentioning
confidence: 99%
“…Paracoccidioidomycosis is endemic in certain parts of South America, especially in Brazil [64]. Outdoor activities such as agriculture are risk factors for infection.…”
Section: Pulmonary Fungal Infectionsmentioning
confidence: 99%
“…The diagnosis can be made after identification of yeast forms in tissue samples or by culturing. Patients with mild to moderate disease are usually treated with itraconazole 200 mg daily for an average duration of 12 months [64]. Co-trimoxazole is recommended as an alternative treatment.…”
Section: Pulmonary Fungal Infectionsmentioning
confidence: 99%