Ectopic forms of schistosomiasis mansoni in the second macroregion of Alagoas: case series report and review of the literature

Abstract

Introduction: Ectopic forms of schistosomiasis are those in which the parasitic element is localized outside the portal system, the natural habitat of the helminth. Although the prevalence rates of schistosomiasis are high in Brazil, clinical and epidemiological data on ectopic forms of the disease are still scarce. Methods: Cross-sectional, retrospective and descriptive epidemiological study in which cases with a confirmed histopathological diagnosis of an ectopic form of schistosomiasis were analyzed. The cases were selected from a database of the anatomic pathology files of a referral center. Results: Of the 21 cases identified, seven affected the female genital tract and five the male genital tract; four cases were identified in the peritoneum; two cases involved lymph nodes and two involved adipose tissue; and renal involvement was detected in one case. Conclusions: The lack of knowledge of the clinical presentation of ectopic forms of schistosomiasis makes the early identification and treatment of this form difficult, with direct implications in the reduction of morbidity and mortality in endemic areas.

Expression of microRNA-223 and microRNA-146b in serum and liver tissue of mice infected with Schistosoma mansoni

“…In contrast, previous studies in S. japonicum mice models demonstrated downregulation of circulatory miRNA-146b but upregulated hepatic expression (Cai et al 2013 ; He et al 2013 ). A possible explanation for this contradiction is that circulatory miRNAs are affected by expression in several tissues such as the intestine, spleen, kidney, and other ectopic sites, especially in schistosomiasis japonicum (Lima et al 2017 ; Cai et al 2018 ).…”

Schistosomiasis Mansoni-Recruited Eosinophils: An Overview in the Granuloma Context

“…Although the eggs are transported through the intestinal wall to be eliminated with the fecal material for the continuity of the Schistosoma life cycle, a large proportion of them can stay trapped in the intestinal wall or even be directed to other organs—mainly, the liver [ 17 ]. Eggs from S. mansoni can also be ectopically located in the spleen [ 18 ], lungs [ 18 , 19 ], reproductive system [ 20 ], and central nervous system [ 21 , 22 ].…”

Fatores De Risco Relacionados Ao Câncer Infantojuvenil: Comunidades Expostas a Agrotóxicos No Ceará

“…Estima-se que cerca de 2,5 a 8 milhões de brasileiros são portadores da esquistossomose (LIMA et al, 2017…”

“…GED Gastroenterologia Endoscopia Digestiva, [S. l.], v. 30, n. 3, p. 103-109, 2011.symptoms, as well as provides information on transmitting snails and existing methods for their control, emphasizing the relevance of the use of plants with molluscicidal properties as an effective strategy to interrupt the evolutionary cycle of the S. mansoni parasite, thus contributing to the reduction of disease cases.KEYWORDS:Schistosomiasis mansoni; Epidemiology; Symptomatology; Control; , 2018). Esta parasitose é um fator limitante do desenvolvimento econômico e social, e ainda tem grande relevância no contexto da saúde pública, pois estima-se que existam quase 240 milhões de infectados no mundo e que mais de 700 milhões de pessoas se encontram em áreas de endemismo(CHENG et al, 2016;ROCHA et al, 2016; WHO, 2019).No Brasil, a esquistossomose é difundida pela espécie Schistosoma mansoni e acomete cerca de 2,5 a 8 milhões de indivíduos(LIMA et al, 2017). A helmintíase é amplamente distribuída, sendo que a área endêmica se estende do Maranhão até Minas Gerais, e outros focos de transmissão são registrados no Pará, Ceará, Piauí, Rio de Janeiro, São Paulo, Paraná, Santa Catarina, Goiás e Rio Grande do Sul (BRASIL, 2017).A presença de planorbídeos Biomphalaria em determinadas localidades, associada à ocorrência de portadores de S. mansoni, representa a condição necessária para o estabelecimento da endemia esquistossomótica.…”