HIV-1 epidemiology and circulating subtypes in the countryside of South Brazil

Librelotto, Carina Sperotto; Gräf, Tiago; Simon, Daniel; Almeida, Sabrina Esteves de Matos; Lunge, Vagner Ricardo

doi:10.1590/0037-8682-0083-2015

Cited by 14 publications

(11 citation statements)

References 39 publications

(29 reference statements)

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“…In the United States and Western Europe, HIV-1 subtype B is the most common variant. In Brazil, HIV subtypes C, F1, and recombinants BC and BF are generally observed at low frequencies as previously described (34) . However, there have been a few studies showing the genetic variability of HIV-1 among patients with HIV-hepatitis coinfections.…”

Section: Discussionsupporting

confidence: 55%

Profile of HCV Genotypes and Hiv-Subtypes Among Hiv-Coinfected Patients in Southern Brazil

Silva

Peder

Thomazella

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: Hepatitis B and C virus (HBV and HCV) are the two most common infections among human immunodeficiency virus (HIV)-infected patients. OBJECTIVE: To identify the frequency of HIV subtypes and HCV genotypes in HIV-coinfected patients. METHODS: A cross-sectional and retrospective study was carried out into two reference centers in Southern Brazil between January 1, 2002 and June 30, 2016. The Abbott Real Time HCV Genotype II system was used for routine diagnostics to determine the HCV genotype based on dual-target real-time PCR. Proviral HIV-1 RNA was extracted from serum samples and fragments of the pol gene were generated by PCR. The HIV-1 PT and RT gene sequences were submitted to Maximum Likelihood Phylogenetic analysis by collecting reference sequences from the HIV-1 group M subtype of the Los Alamos database. RESULTS: During the study period, 3340 patients with HIV were diagnosed at both referral centers, of which 4.97% (166/3340) had HBV and/or HCV coinfection. Seroprevalence of HIV-HBV, HIV-HCV and HIV-HBV-HCV was 37.4%, 58.4%, and 4.2%, respectively. HIV-HCV-coinfected patients had a lower median nadir CD4+ T-cell count when compared to HIV-HBV-coinfected patients (P=0.01). Among those coinfected with HCV, HCV-1 (HCV-1) and HCV-3 (HCV-3) genotypes were the most prevalent, being detected in 73.8% and 21.4%, respectively. Among the HCV-1 coinfected patients, 79.3% and 20.1% had subtypes 1a and 1b, respectively. HIV subtype B was the most prevalent in HIV-coinfected patients. There was no significant difference regarding nadir CD4+ T-cell count and HIV viral load when compared to coinfected with HCV-1 with HCV-3, as well as those co-infected with HCV-1a with HCV-1b. CONCLUSION: In the present study, a higher frequency of subtype B of HIV and HCV-1 were found in HIV-coinfected patients. Further larger-scale and long-term studies are needed to better understand the effect of HCV genotypes in HIV-infected patients.

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Section: Discussionsupporting

confidence: 55%

Profile of HCV Genotypes and Hiv-Subtypes Among Hiv-Coinfected Patients in Southern Brazil

Silva

Peder

Thomazella

et al. 2019

Arq. Gastroenterol.

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“…This was consistent with other data from Brazil [12][13][14][15][16][17][18][19][20] with the exception of the southern states, where subtype C has been found to prevail. 21 To a lesser extent, presence of recombinant forms between subtypes B and F, K and between F and subtype F1 was also found. Subtype C was not observed in the samples, but the prevalence of this subtype is increasing in Brazil, 22 apparently with disease progression characteristics differing from those of subtype B.…”

Section: Discussionmentioning

confidence: 93%

HIV-1 genetic diversity and resistance to antiretroviral drugs among pregnant women in Ribeirão Preto (SP), Brazil. Cross-sectional study

et al. 2018

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“…O Ministério da Saúde destaca que nos últimos anos a disseminação do HIV tomou grandes proporções no Brasil, principalmente em municípios de pequeno e médio porte. 3 139 (12,20) 44 (3,87) 851 (87, 19) 125 (12, em um estudo realizado na zona rural do sul do Brasil, onde a orientação sexual dos indivíduos estudados era principalmente heterossexual (97,6% mulheres e 85,1% homens), baixo nível de educação (73,8%), forma de transmissão do vírus principalmente sexual (85,9%) e o tempo de diagnóstico médio de 6,2 ± 5,6 anos. 19 Resultados semelhantes aos apresentados neste estudo também foram encontrados no Chile, onde houve predomínio da infecção no sexo masculino (75,4%) e em indivíduos solteiros (55,8%).…”

Section: Discussionunclassified

Perfil epidemiológico dos pacientes com HIV em um centro de referência no sul do Brasil. Características de dez anos.

Silva

Jorge

Dalbosco

et al. 2017

Rev Epidemiol Control Infect

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Justificativa e Objetivos: A epidemia da infecção pelo HIV constitui um verdadeiro mosaico de sub-epidemias regionais. O estudo possuiu como objetivo descrever o perfil 2 dos pacientes recém-infectados com HIV em um centro de referência no Sul do Brasil. Métodos: Trata-se de um estudo transversal, a partir de informações de prontuários e da Rede Nacional de Sistema de Controle de Testes de Laboratório. Foi realizada uma análise descritiva, agrupadas pelo sexo, das características ociodemográficas, comportamentais e sorológica dos pacientes infectados pelo HIV, entre janeiro de 2005 a dezembro 2014. A associação entre as variáveis qualitativas foi realizada utilizando-se os testes Qui-quadrado ou Teste Exato de Fisher, e as quantitativas foram analisadas pelo Teste de Wilcoxon. O nível de significância foi fixado em 5%. Resultados: A epidemia apresentou taxas crescentes, principalmente no sexo masculino e no município de Cascavel. A mediana da idade da população foi de 33 anos, sendo que 680 (57,43 %) eram homens. Em relação ao estado civil, o sexo masculino era predominantemente solteiro (51,99% versus (vs.) 34,10%). O tempo de diagnóstico menor/igual a dois anos foi maior entre os homens (29,26% vs. 20,83%). A mediana da ontagem de células T CD4+ no sexo feminino foi superior ao masculino (416 células/mm3 vs. 334,5 células/mm3 ; p < 0,0001). Conclusão: Os características sociodemográficas, comportamentais e as disparidades regionais devem ser levadas em conta na formulação de programas de prevenção. DESCRITORES: HIV. Epidemiologia. Síndrome de Imunodeficiência Adquirida.

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HIV-1 epidemiology and circulating subtypes in the countryside of South Brazil

Cited by 14 publications

References 39 publications

Profile of HCV Genotypes and Hiv-Subtypes Among Hiv-Coinfected Patients in Southern Brazil

Profile of HCV Genotypes and Hiv-Subtypes Among Hiv-Coinfected Patients in Southern Brazil

HIV-1 genetic diversity and resistance to antiretroviral drugs among pregnant women in Ribeirão Preto (SP), Brazil. Cross-sectional study

Perfil epidemiológico dos pacientes com HIV em um centro de referência no sul do Brasil. Características de dez anos.

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