High incidence of hypertriglyceridemia in a Brazilian cohort of people living with HIV/AIDS undergoing antiretroviral treatment in Belo Horizonte, 2001-2010

Mendicino, Cássia Cristina Pinto; Braga, Letícia Pena; Pádua, Cristiane Aparecida Menezes de; Guimarães, Mark Drew Crosland

doi:10.1590/0037-8682-0078-2016

Cited by 8 publications

(4 citation statements)

References 13 publications

(14 reference statements)

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“…Here, our study paralleled these previous studies, demonstrating that the hyperlipidemia group had a higher level of ART usage. In addition, a meta-analysis of previous studies and our study showed that patients with ART use had a higher hyperlipidemia risk than patients who were not using ART ( Supplementary Table 3 and Supplementary Figures 1–2 ) [ 28 , 29 ]. Our results also suggest that HIV patients may have a higher hyperlipidemia risk when they receive ART regimens in dose- and adherence- dependent manners, especially in the cases of PI, NRTI, and NNRTI regimens.…”

Section: Discussionmentioning

confidence: 62%

Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era

et al. 2017

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HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in the Taiwanese HIV/ART cohort. A total of 13,370 HIV-infected patients (2,674 hyperlipidemia and 10,696 non-hyperlipidemia patients) were recruited after matching for age, gender, and the first diagnosis date of HIV infection by using the National Health Insurance Research Database in Taiwan. Hyperlipidemia risk associated with cumulative ART use, ART adherence, and their combination was assessed. The matched hyperlipidemia group had a larger number of patients using ART and a higher incidence of comorbidities, specifically, respiratory disease and diabetes. Patients with high ART dosage and dose-dependent manner adherence, respectively, demonstrated an increased risk of hyperlipidemia. For single ART regimens, patients receiving nucleoside reverse-transcriptase inhibitors (NRTI/NRTI)- containing regimen had the highest hyperlipidemia risk, followed by protease inhibitor (PI)- containing and non-NRTI- containing regimens. For combination ART regimens, patients receiving a NRTI/NRTI + PI regimen had the highest hyperlipidemia risk. An increased cumulative drug dose was observed in patients who received the PI, NRTI/NRTI, NRTI, and NNRTI regimens in the hyperlipidemia group, when compared to the non-hyperlipidemia group. In conclusion, ART cumulative use, adherence, and regimen may affect hyperlipidemia risk among HIV-infected patients in a dose-dependent manner.

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Section: Discussionmentioning

confidence: 62%

Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era

et al. 2017

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“…Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is associated with opportunistic pathologies due to low activity of the immune system ( Raso et al, 2007 ). Highly active antiretroviral therapy (HAART) is widely recommended for patients with HIV/AIDS as a way to prevent the onset of these pathologies ( Chow et al, 2017 ; Mendicino et al, 2016 ). However, HAART increases the cardiovascular risk of the patients ( Hsue et al, 2009 ; Lipshultz et al, 2003 ; Zareba et al, 2005 ), especially women ( Muyanja et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Blood pressure responses after resistance exercise session in women living with human immunodeficiency virus/acquired immunodeficiency syndrome

et al. 2018

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The aim of this study was to verify blood pressure (BP) responses after a single resistance exercise session in women with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Twelve patients underwent a resisted exercise session. BP, heart rate, and rate pressure product were evaluated before and during 120 min after the session. Mean cardiovascular values before and after the session were similar (P>0.05). Analysis of the individual data revealed that for 120 min after exercise, 5 and 4 patients presented a reduction in systolic and diastolic BP of ≥4 mmHg, respectively. The clinical characteristics of the patients appear to influence BP responses after exercise. Individual data showed that some of the HIV+ women demonstrated a clinically significant decrease in BP. Although a single resistance exercise session does not decrease BP in women with HIV/AIDS, individual data present heterogeneity and individual characteristics seem to influence BP reduction after a single session of resistance exercises.

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“…Generally, protease inhibitors, nucleoside reverse-transcriptase inhibitors (NRTIs), and non-NRTIs (NNRTIs) all increase triglyceride levels and newer drugs have more favorable effects compared to older ones [ 1 , 2 ]. In addition, studies found that the prevalence of hypertriglyceridemia was higher in males with HIV [ 7 , 8 ]. A recent study showed that hypertriglyceridemia is associated with subclinical atherosclerosis and vascular inflammation even in participants with normal low-density lipoprotein cholesterol levels [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Incidence and risk factors of hypertriglyceridemia in males with human immunodeficiency virus who are treated with combination antiretroviral therapy: a retrospective cohort study

Huang

Jiao

et al. 2023

Lipids Health Dis

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Background Hypertriglyceridemia is associated with subclinical atherosclerosis and vascular inflammation even when low-density lipoprotein cholesterol levels are normal. However, few cohort studies on hypertriglyceridemia have been conducted in males with higher susceptibility to human immunodeficiency virus (HIV)-related deterioration of arterial structure and function. Our objective was to investigate the incidence of hypertriglyceridemia during treatment with combination antiretroviral therapy (cART) in males with HIV and explore its related risk factors. Methods In this retrospective study, we included 309 males living with HIV (median age 31 years [interquartile range 26–42.5]) who initiated cART treatment in our hospital from January 2013 to December 2018. We collected follow-up data on serum triglycerides and other related information as of June 31, 2021. A Cox proportional hazards regression model was used to analyze the related risk factors. Results In 666.7 person-years, hypertriglyceridemia occurred in 140 patients (triglyceride ≥2.3 mmol/L [200 mg/dL]), and the incidence rate was 21.0 per 100 person-years (Patients who took the lamivudine [3TC] + tenofovir disoproxil fumarate [TDF] + efavirenz [EFV] regimen accounted for 77.0% of the total patients.). Multiple Cox regression analysis showed that baseline CD4/CD8 ratio < 0.20 (hazard ratio [HR], 2.705 [95% confidence interval (CI): 1.381–5.296]; P = 0.004}, body mass index (BMI) ≥ 24.0 kg/m2 (HR, 1.768 [95% CI: 1.225–2.552]; P = 0.002), borderline high triglyceride at baseline (HR, 3.457 [95% CI: 2.162–5.527]; P < 0.001), and 3TC + zidovudine (AZT) + EFV regimen (HR, 2.702 [95% CI: 1.593–4.581]; P < 0.001), or 3TC + TDF + lopinavir/ritonavir (LPV/r) regimen (HR, 4.349 [95% CI: 2.664–7.102]; P < 0.001) were independent risk factors for hypertriglyceridemia. Conclusion During the course of cART treatment, the incidence of hypertriglyceridemia in males with HIV was high. The main risk factors influencing its occurrence are a low baseline CD4/CD8 ratio, overweight and obesity, and the use of AZT or LPV/r in the cART regimen.

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High incidence of hypertriglyceridemia in a Brazilian cohort of people living with HIV/AIDS undergoing antiretroviral treatment in Belo Horizonte, 2001-2010

Cited by 8 publications

References 13 publications

Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era

Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era

Blood pressure responses after resistance exercise session in women living with human immunodeficiency virus/acquired immunodeficiency syndrome

Incidence and risk factors of hypertriglyceridemia in males with human immunodeficiency virus who are treated with combination antiretroviral therapy: a retrospective cohort study

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