Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia

Martinez-Salazar, Edgar L; Tobón-Castaño, Alberto

doi:10.1590/0037-8682-0078-2014

Cited by 26 publications

(20 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 B), though both naïve and semi-immune groups exhibited platelet depletion after P. vivax infection ( Fig. 5 C), consistent with previous literature [47] . Associated with this hub are many metabolite clusters encompassing 881 features (p < 0.05 Figs.…”

Section: Resultssupporting

confidence: 91%

Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling

et al. 2018

View full text Add to dashboard Cite

Almost invariably, humans become ill during primary infections with malaria parasites which is a pathology associated with oxidative stress and perturbations in metabolism. Importantly, repetitive exposure to Plasmodium results in asymptomatic infections, which is a condition defined as clinical tolerance. Integration of transcriptomics and metabolomics data provides a powerful way to investigate complex disease processes involving oxidative stress, energy metabolism and immune cell activation. We used metabolomics and transcriptomics to investigate the different clinical outcomes in a P. vivax controlled human malaria infection trial. At baseline, the naïve and semi-immune subjects differed in the expression of interferon related genes, neutrophil and B cell signatures that progressed with distinct kinetics after infection. Metabolomics data indicated differences in amino acid pathways and lipid metabolism between the two groups. Top pathways during the course of infection included methionine and cysteine metabolism, fatty acid metabolism and urea cycle. There is also evidence for the activation of lipoxygenase, cyclooxygenase and non-specific lipid peroxidation products in the semi-immune group. The integration of transcriptomics and metabolomics revealed concerted molecular events triggered by the infection, notably involving platelet activation, innate immunity and T cell signaling. Additional experiment confirmed that the metabolites associated with platelet activation genes were indeed enriched in the platelet metabolome.

show abstract

Section: Resultssupporting

confidence: 91%

Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Non-severe thrombocytopaenia was found in almost half of complicated malaria cases, similar to a previous report in Colombia [ 6 ]. That is an important manifestation since altered platelet indices have been found as potential markers of severe malaria [ 18 , 35 ]. Unfortunately, further information of severe thrombocytopaenia in patients studied here was not available.…”

Section: Discussionmentioning

confidence: 99%

Clinical and epidemiological aspects of complicated malaria in Colombia, 2007–2013

Chaparro-Narváez¹,

Lopez-Perez

Rengifo

et al. 2016

Malar J

View full text Add to dashboard Cite

BackgroundDuring the last decade, Colombia presented a significant decrease in malaria clinical cases and associated mortality. However, there is a lack of reliable information about the prevalence and characteristics of complicated malaria cases as well as its association with different Plasmodium species. A description of the epidemiological and clinical aspects of complicated malaria in Colombia is presented here.MethodsA descriptive study was conducted using data collected between 2007 and 2013 by the Public Health Surveillance System (SIVIGILA). Demographic and clinical features were described. Frequency of complicated malaria cases, annual parasite index (API) and annual percent change (APC) for trend modelling by gender and age were also calculated.ResultsA total of 547,542 malaria cases were recorded by SIVIGILA during the study period, of which 2553 (0.47 %) corresponded to complicated cases with similar distribution by Plasmodium vivax and Plasmodium falciparum species. Mixed infections were found in 153 cases (6.0 %). Trend modelling of the API for complicated malaria for all parasite species showed a non-significant increase throughout the years (APC 14.4 %; 95 % CI −4.3 to 36.6 %). Complicated malaria individuals were mostly males (62.2 %) and young adults (median age of 23 years). Notably, 72.4 % of the patients attended for malaria diagnosis >72 h after symptoms onset and 17 % reported malaria episodes in the last 30 days. All patients received anti-malarial treatment, but only 40 % received the first-line as recommended by the Colombian guidelines. Overall, hepatic and renal complications were the most common severe manifestations (63.6 %). Whereas hepatic and pulmonary complications were more common in P. vivax infections, renal and cerebral complications were significantly more frequent in patients with P. falciparum. In contrast with mono-infected patients, severe anaemia and shock were more frequent in patients with mixed infection.ConclusionIn contrast with the malaria-decreasing trend over the last years, the complicated malaria trend showed a non-significant annual increase. Therefore, in addition to existing national policies on early diagnosis and prompt anti-malarial treatment, more efforts have to be committed addressing the delayed diagnosis and inadequate treatment found in this study. Improving malaria notification forms, medical assistance skills, and capacity should be prioritized.Electronic supplementary materialThe online version of this article (doi:10.1186/s12936-016-1323-5) contains supplementary material, which is available to authorized users.

show abstract

“…Malaria can affect any organ or system, the hematological system being the most affected one. The majority of described alterations occur on the red cell line and platelets, causing anemia and thrombocytopenia [ 6 – 8 ]. Alterations in the white blood cell (WBC) counts are less reported and have been associated with factors such as severity, Plasmodium species, concurrent infections, and treatment response [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Leukogram Profile and Clinical Status invivaxandfalciparumMalaria Patients from Colombia

Tobón-Castaño

Mesa-Echeverry

Miranda-Arboleda

2015

Journal of Tropical Medicine

Self Cite

View full text Add to dashboard Cite

Introduction. Hematological alterations are frequent in malaria patients; the relationship between alterations in white blood cell counts and clinical status in malaria is not well understood. In Colombia, with low endemicity and unstable transmission for malaria, with malaria vivax predominance, the hematologic profile in malaria patients is not well characterized. The aim of this study was to characterize the leukogram in malaria patients and to analyze its alterations in relation to the clinical status. Methods. 888 leukogram profiles of malaria patients from different Colombian regions were studied: 556 with P. falciparum infection (62.6%), 313 with P. vivax infection (35.2%), and 19 with mixed infection by these species (2.1%). Results. Leukocyte counts at diagnosis were within normal range in 79% of patients and 18% had leucopenia; the most frequent alteration was lymphopenia (54%) followed by monocytosis (11%); the differential granulocyte count in 298 patients revealed eosinophilia (15%) and high basophil counts (8%). Leukocytosis, eosinopenia, and neutrophilia were associated with clinical complications. The utility of changes in leukocyte counts as markers of severity should be explored in depth. A better understanding of these hematological parameters will allow their use in prompt diagnosis of malaria complications and monitoring treatment response.

show abstract

Platelet profile is associated with clinical complications in patients with vivax and falciparum malaria in Colombia

Cited by 26 publications

References 40 publications

Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling

Integrative metabolomics and transcriptomics signatures of clinical tolerance to Plasmodium vivax reveal activation of innate cell immunity and T cell signaling

Clinical and epidemiological aspects of complicated malaria in Colombia, 2007–2013

Leukogram Profile and Clinical Status invivaxandfalciparumMalaria Patients from Colombia

Contact Info

Product

Resources

About