2013
DOI: 10.1590/0037-8682-0064-2012
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Abstract: Introduction:The diagnosis of schistosomiasis mansoni on early stages of infection is important to prevent late morbidity. A simple, cheap, sensitive and specific assay for routine diagnosis of schistosome infection based on the detection of specific IgG for schistosomula tegument antigens (ELISA-SmTeg) was developed by our group. Methods: We describe here an acute outbreak involving a travel group of 80 individuals from a non-endemic area of the State of Minas Gerais, Brazil. These individuals were in contact… Show more

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Cited by 15 publications
(20 citation statements)
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“…Adult Schistosoma worm membrane extracts have been applied in immunoblots for detecting antibodies against S. intercalatum, and an alkaline phosphatase immune capture assay (APIA) has also been developed for diagnosing this infection in patients (144,145). An ELISA detecting specific IgG against schistosomula tegument antigens (ELISA-SmTeg) has shown an improved performance compared to that for an assay detecting antibody against AWA, particularly in diagnosing early-stage acute S. mansoni infections among individuals in a travel group from an area in Brazil where the disease is not endemic, who were infected in a new focus of S. mansoni (146). Furthermore, the SmCTF-ELISA was later applied in an effective lateral flow device that was used as a pointof-care rapid diagnostic test (RDT).…”
Section: Antibody Detectionmentioning
confidence: 99%
“…Adult Schistosoma worm membrane extracts have been applied in immunoblots for detecting antibodies against S. intercalatum, and an alkaline phosphatase immune capture assay (APIA) has also been developed for diagnosing this infection in patients (144,145). An ELISA detecting specific IgG against schistosomula tegument antigens (ELISA-SmTeg) has shown an improved performance compared to that for an assay detecting antibody against AWA, particularly in diagnosing early-stage acute S. mansoni infections among individuals in a travel group from an area in Brazil where the disease is not endemic, who were infected in a new focus of S. mansoni (146). Furthermore, the SmCTF-ELISA was later applied in an effective lateral flow device that was used as a pointof-care rapid diagnostic test (RDT).…”
Section: Antibody Detectionmentioning
confidence: 99%
“…This disease is caused by the trematode Schistosoma [29]. It is often found in sub-Saharan Africa, South America, and Asia but it is also more recently moving to areas that it was not as common previously due to tourism [19,30]. It can occur at any time through parasitic infection [31].…”
Section: Schistosomiasismentioning
confidence: 99%
“…These antibodies can be directed against any of the four stages of the Schistosoma genus which includes penetrating cercariae, schistosomula which is the migration of juvenile worms, the presence of adult worms, and eggs produced by worms through mating [23,32,35]. For the serological assays that have been taken, some have been found to be specific for endemic regions [30,[38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56].…”
Section: Pathogenesismentioning
confidence: 99%
“…It is currently acknowledged that the KK test lacks sensitivity especially in low endemic areas [14]. The search for a reliable tool for monitoring and surveillance of schistosomiasis has led to various antigens being investigated for sero-diagnostic tests [15]: schistosomula tegumental antigens [16,17], soluble egg antigens (SEA) [18], soluble worm antigen preparation (SWAP), and cercarial transformation fluid [19,20]. Tests based on the detection of specific antibodies against these antigens provide variable advantages and drawbacks that limit their applicability [21].…”
Section: Introductionmentioning
confidence: 99%