Colonic basidiobolomycosis with liver involvement masquerading as gastrointestinal lymphoma: a case report and literature review

Abstract

Basidiobolomycosis is an unusual fungal skin infection that rarely involves the gastrointestinal tract. This study reported a 5-year-old boy with gastrointestinal basidiobolomycosis that had been misdiagnosed as gastrointestinal lymphoma. He was treated by surgical resection and a combination of posaconazole and amphotericin B deoxycholate with an acceptable response and no recurrence.

Gastrointestinal basidiobolomycosis: An emerging mycosis difficult to diagnose but curable. Case report and review of the literature

“…As in previous cases, in our patient the route of acquisition of the disease remains unknown; however since B. ranarum can be found in soil and decaying vegetables, we hypothesized that the consumption of homebrew unpasteurized and unfiltered beer might have been the source of fungal ingestion and subsequent involvement of the intestine. A preliminary misdiagnosis among patients with GIB was commonly reported in the literature, the most frequent being gastrointestinal malignancy and inflammatory bowel diseases [17,22,30,33,34,36,37,41,42,56,61,62,PR], although a suspicion should be raised whenever fever and abdominal pain occur in young patients with gastrointestinal, abdominal mass or intestinal wall thickening in association with high eosinophilia.…”

“…Although a definite diagnosis can be obtained with culture [14,15,18,19,[22][23][24]30,33,35,41,45,47,[49][50][51]54,59,62], it was frequently missed in previous reports because of the lack of suspicion that made tissue specimens unavailable for culture purpose. Therefore, the diagnosis of gastrointestinal infection by B. ranarum was mainly obtained on histologic examination, which typical morphologic features include granulomatous inflammation and a diffuse eosinophilic infiltrate with thin walled branched hyphae surrounded by eosinophilic material (Splendore-Höeppli phenomenon) and sometimes zygospores (spherical bodies with foamy cytoplasm) [4,6,12,16,17,20,24,[26][27][28][29][31][32][33][35][36][37][38][39][42][43][44]46,49,52,53,…”

A Very Rare Basidiobolomycosis Case Presented with Cecal Perforation and Concomitant Hepatic Involvement in an Elderly Male Patient: A Case Study

“…Table 1 provides a summary of the reported case of Basidiobolomycosis with colonic and liver involvement. [12] 18-year-old women (Jazan, Saudi Arabia).…”

A case of basidiobolomycosis mimicking rhabdomyosarcoma: A diagnostic challenge

“…Extracutaneous manifestations are diverse and nonspecific depending on the tissue involved; patients with B. ranarum infection may present with subcutaneous, gastrointestinal, or systemic lesions [4] . Consequently, gastrointestinal basidiobolomycosis (GIB) is recognized in the literature as a cause of misdiagnosis due to its ability to mimic the manifestations of more common entities such as benign tumors, malignancies, inflammatory bowel disease, appendicitis, tuberculosis, etc.…”