Bone tuberculosis: a case report on child

Santos, Fabiana Cristina Fulco; Nascimento, André Luiz Alves do; Lira, Laís Ariane de Siqueira; Lima, Juliana Figueirêdo da Costa; Montenegro, Rosana de Albuquerque; Montenegro, Lílian Maria Lapa; Schindler, Haiana Charifker

doi:10.1590/0037-8682-0010-2012

Cited by 8 publications

(8 citation statements)

References 6 publications

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“…Spinal TB is uncommon in infancy as it takes more than 1 year to develop. Moreover, paraplegia or quadriplegia are less severe in infants and hence diagnosis gets delayed 5 . Pyrexia of unknown origin and sudden appearance of gibbus made us suspect spinal TB.…”

Section: Discussionmentioning

confidence: 99%

Pott’s spine in an infant: a diagnostic challenge

Mahapatra

Mukherjee

Kundu

et al. 2017

Sri Lanka J Child Health

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Section: Discussionmentioning

confidence: 99%

Pott’s spine in an infant: a diagnostic challenge

Mahapatra

Mukherjee

Kundu

et al. 2017

Sri Lanka J Child Health

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“…The clinical symptoms of spinal tuberculosis in children are often insidious and include back pain, fever, paraparesis, sensory disturbances, and bowel and bladder dysfunction ( 11 ). In the literature, kyphosis and thoracic spine deformities related to the collapse of the T11 and T12 vertebral bodies were reported due to late diagnosis ( 12 ). In the present case, the MRI findings showed the degeneration of the corpus inferior of the T8, T9, and T10 vertebrae; corpus damage of T9 and T10; and a 30 × 12 × 72 mm abscess in the prevertebral space.…”

Section: Discussionmentioning

confidence: 99%

“…We did not repeat the biopsy, which is a weakness in this case report. As an early TB indicator, a positive tuberculin test is strongly indicative of the presence of tuberculosis ( 12 ). In our case, the tuberculin test was positive, and this supported the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Coexistence of a Ghon Complex, Pott’s Disease, and Hip Arthritis in a Child

Yiğit

Erol

Gayret

et al. 2016

Iran Red Crescent Med J

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IntroductionTuberculosis remains a major public health problem in developing countries. Diagnosing extrapulmonary tuberculosis can be difficult, as it requires a higher index of suspicion than primary tuberculosis. Extrapulmonary tuberculosis may mimic malignancies and many other diseases, so it should be included in the differential diagnosis. Here, we present a case of extrapulmonary tuberculosis associated with Pott’s disease and hip arthritis in a patient who recovered after 12 months of antituberculosis therapy.Case PresentationA 16-year-old girl presented to the outpatient otolaryngology clinic with painless swelling of the neck, and to the physical medicine and rehabilitation clinic with complaints of hip and low back pain that mimicked spondyloarthropathy. She was eventually referred to the outpatient pediatric clinic. Her acute-phase reactants were high, and hilar lymphadenopathy was evident on chest x-ray. On computerized tomography, a Pott’s abscess involving the T8, T9, and T10 vertebrae was suspected. Magnetic resonance imaging of the dorsal vertebrae and hip was performed, and a Pott’s abscess and hip tuberculous arthritis were confirmed. The patient had been exposed to tuberculosis 10 years earlier, and her purified protein derivative (PPD) test was 16 mm. After antituberculosis treatment, our patient recovered and the Pott’s disease and hip tuberculous arthritis regressed.ConclusionsExtrapulmonary tuberculosis may mimic many other diseases, so it should be kept in mind in the differential diagnosis. It is essential to diagnose osteoarticular tuberculosis early, as late diagnosis or inadequate treatment may cause permanent disability.

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“…Molecular tests based on M. tuberculosis genomic fragment amplifi cation are rapid and sensitive techniques that can detect less than 10 bacilli per ml in a clinical sample 14,15 . Although conventional polymerase chain reaction (PCR) is useful for M. tuberculosis detection, the nested-PCR (nPCR) technique has greater sensitivity and specifi city for the test, indicating that it is a promising laboratory tool for diagnosing paucibacillary forms of TB, including the pleural form 6,14,16,17 .…”

Section: Methodsmentioning

confidence: 99%

The performance of an in-house nested-PCR technique for pleural tuberculosis diagnoses

Montenegro

Silva

Lima

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: This study evaluated the performance of an in-house nested-PCR system for the detection of the Mycobacterium tuberculosis complex in pleural fl uid, blood and urine samples from pleural effusion tuberculosis patients by health services physicians in Pernambuco, Brazil. Methods: A prospective double-blind study with 37 hospitalized patients of both sexes, aged over 15, was used to investigate the diagnosis of pleural effusion. The criteria used to defi ne the cases included the demonstration of bacillus in biological samples by smear or culture or by a granulomatous fi nding in the histopathological examination, associated with an evident response to specifi c treatments to each clinical situation. Pleural fl uid, blood and urine samples were collected and subjected to routine tests and the nested PCR technique to assess for M. tuberculosis amplifi cation. Results: In total, 37 pleural effusion patients took part in the study, of whom 19 (51.3%) had tubercular etiologies and 18 (48.7%) had etiologies from other causes. When the pleural fl uid, blood and/or urine sample in-house nested-PCR sensitivities were evaluated simultaneously, the results were positive regardless of the biological specimen (the sensitivity was 84.2%); however, when the blood and/or urine samples were analyzed together, the sensitivity was 72.2%. When the pleural fl uid samples were evaluated alone, the sensitivity was only 33.3%. Conclusions: The performance of the diagnostic pleural tuberculosis nested-PCR was directly related to the diversity of the samples collected from the same patient. Additionally, this study may identify a need to prioritize non-invasive blood and urine collection for this diagnosis.

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Bone tuberculosis: a case report on child

Cited by 8 publications

References 6 publications

Pott’s spine in an infant: a diagnostic challenge

Pott’s spine in an infant: a diagnostic challenge

Coexistence of a Ghon Complex, Pott’s Disease, and Hip Arthritis in a Child

The performance of an in-house nested-PCR technique for pleural tuberculosis diagnoses

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