Genes related to maintenance of autophagy and successful aging

Abstract

Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults. The expression profile of autophagic pathway-related genes was carried out in peripheral blood, and the proteasome quantification was performed in plasma. No significant changes were found in plasma proteasome concentrations or in correlations between proteasome concentrations and ages. However, some autophagy- and/or apoptosis-related genes were differentially expressed. In addition, the network and enrichment analysis showed an interaction between four of the five differentially expressed genes and an association of these genes with the transcriptional process. Considering that the oldest old individuals maintained both the expression of genes linked to the autophagic machinery, and the proteasome levels, when compared with the older group, we concluded that these factors could be considered crucial for successful aging.

Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy

“…An analysis of gene regulatory networks for ICS response in mid-childhood identified enrichment of pro-apoptosis pathways in good ICS responders, and anti-apoptosis pathway enrichment in poor ICS responders. While cellular apoptosis is a natural process occurring at all stages of human development, changes in expression of apoptosis genes occur with age [35,36]. In our study, alterations in SMARCD1 expression with age may relate to its involvement in apoptosis pathways.…”

A qualitative cross-case analysis of older adults’ acceptance and resiliency behaviors amidst the COVID-19 pandemic crisis

“…In the process of aging, health-related events occur that compromise activities or even independence emergent evidence have demonstrated concerns among older persons in achieving successful aging, especially during the COVID-19 pandemic crisis, which has resulted in difficulty achieving physical independence, satisfaction, and other related societal appreciation. However, older adults may exist with at least minimal ability to overcome difficulties and adjust to the challenges of advanced age despite advancing age in consideration of a phenomenon of a decline in every person's essential process (Chaves et al, 2018;Araújo et al, 2016;Martin et al, 2015). Therefore, an essential component that contributes to age successfully is developing resilience and coping effectively while acceptance of aging toward changing well-being later in life (Hochhalter et al, 2011).…”

Positively Correlated CD47 Activation and Autophagy in Umbilical Cord Blood-Derived Mesenchymal Stem Cells during Senescence

“…An alternating lysosomal degradation system and decreased autophagic activity were ensued by aging. Commonly, impaired and defective autophagy in aged cells has been identified [10,11]. The decline in both the number and functionality of stem cells with aging may contribute to regenerative decline.…”