Acute methanol poisoning

Severe visual loss caused by inhalational methanol poisoning in fireworks production: A report on 3 cases

“…Formic acid, the end‐product of methanol metabolism, directly inhibits the activity of cytochrome oxidase in mitochondria and interferes with adenosine triphosphate (ATP) production. It can result in neuronal cellular hypoxia that preferentially affects the retina and optic nerve causing severe visual dysfunction 3 . Methanol intoxication additionally leads to metabolic acidosis, permanent neurological dysfunction, cardiovascular instability, and even death.…”

Reply

“…I thank Drs. Sookaromdee and Wiwanitkit for their comments on the manuscript entitled "Acute methanol poisoning" 1 . The readers argue that "it is difficult to judge that the case is an actual neurological problem due to methanol poisoning" and that "the high plasma methanol level, but normal osmolar gap, should be discussed".…”