Suicidal ideation, anxiety, and depression in patients with multiple sclerosis

Tauil, Carlos Bernardo; Grippe, Talyta Cortez; Dias, Ronaldo Maciel; Carneiro, Rafael; Carneiro, Narel Moita; Aguilar, Ana Carolina; Silva, Flávia Martins da; Bezerra, Felipe; Almeida, Leonardo Kenzo de; Massarente, Vitoria Lana; Giovannelli, Elaine de Carvalho; Tilbery, Charles Peter; Brandão, Carlos Otávio; Santos, Leonilda Maria Barbosa dos; Santos-Neto, Leopoldo Luiz dos

doi:10.1590/0004-282x20180036

Cited by 42 publications

(32 citation statements)

References 18 publications

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“…A score of >17 indicates clinical depression. Studies showed that BDI‐II scores were positively associated with suicidal ideation and suicide attempts (Badiee et al, ; Doshi et al, ; Tauil et al, ).…”

Section: Methodsmentioning

confidence: 99%

Interpersonal Risk Factors for Suicide in Cocaine Dependence: Association with Self‐Esteem, Personality Traits, and Childhood Abuse

Zhornitsky

Dhingra

et al. 2020

Suicide & Life Threat Behav

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Objective Studies have linked cocaine dependence to suicidality. According to the Interpersonal Theory of Suicide, suicidal behavior becomes likely with the simultaneous presence of perceived burdensomeness (PB), lack of (or thwarted) belongingness (TB), and acquired fearlessness about death (FAD). Here, we examined personality and other variables, including depression, self‐esteem, childhood abuse, and substance use, as predictors of these risk factors in cocaine‐dependent individuals (CDs). Methods Seventy CDs and 70 healthy controls (HCs) participated. We examined group differences in a group‐by‐sex analysis of variance and identified predictors of PB, TB, and FAD in stepwise regressions. Results CDs exhibited elevated PB and TB but not FAD, compared to HCs. CDs also exhibited elevated harm avoidance, novelty seeking, depression, and lower self‐esteem and reward dependence. Females reported elevated sexual abuse, harm avoidance, reward dependence, depression, but lower FAD, relative to males, among CDs and HCs. Among CDs, PB was predicted by lower self‐esteem and greater emotional abuse; TB was predicted by lower self‐esteem and reward dependence, as well as greater emotional and sexual abuse; and FAD was predicted by lower harm avoidance and greater physical abuse. Conclusions Interventions targeting suicidality in cocaine dependence should take into consideration self‐esteem, personality traits, and childhood abuse.

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Section: Methodsmentioning

confidence: 99%

Interpersonal Risk Factors for Suicide in Cocaine Dependence: Association with Self‐Esteem, Personality Traits, and Childhood Abuse

Zhornitsky

Dhingra

et al. 2020

Suicide & Life Threat Behav

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“…Clinical studies reported that CD8+ T lymphocyte levels in MS depressed patients are significantly increased compared to non-depressed patients, although CD4+ T lymphocytes play an important role in triggering depressive symptoms in MS, as suggested by other authors (Morris et al, 2018). CD8+ T lymphocytes are more frequently detectable in serum of MS patients during active phases (Kaskow and Baecher-Allan, 2018), and the incidence of depressive symptoms in the course of MS is more elevated during clinical relapses, consequently related to the increase in CD8+-mediated cell immunity during disease exacerbation (Tauil et al, 2018).…”

Section: The Role Of Lymphocytes In Ms Depressionmentioning

confidence: 70%

“…It is a heterogeneous disorder caused by a complex interaction between genetic and environmental factors (Wang et al, 2015;Fakhoury, 2016;Otte et al, 2016;Shadrina et al, 2018). Stress is a major risk factor for depression, in particular early life stress, and enduring stress exerted on susceptible individuals may ultimately lead to Major Depressive Disorder (MDD) and eventually suicide behavior (Bielau et al, 2005;Otte et al, 2016;Tauil et al, 2018). Pathophysiological hallmarks of depressive symptoms include monoamine depletion, glucocorticoid receptor (GR) resistance, corticotrophin-releasing hormone and cortisol levels as well as excess of glutamate (Boku et al, 2018;Seki et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis

Bruno

Dolcetti

Rizzo

et al. 2020

Front. Cell. Neurosci.

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In the past years, several theories have been advanced to explain the pathogenesis of Major Depressive Disorder (MDD), a neuropsychiatric disease that causes disability in general population. Several theories have been proposed to define the MDD pathophysiology such as the classic “monoamine-theory” or the “glutamate hypothesis.” All these theories have been recently integrated by evidence highlighting inflammation as a pivotal player in developing depressive symptoms. Proinflammatory cytokines have been indeed claimed to contribute to stress-induced mood disturbances and to major depression, indicating a widespread role of classical mediators of inflammation in emotional control. Moreover, during systemic inflammatory diseases, peripherally released cytokines circulate in the blood, reach the brain and cause anxiety, anhedonia, social withdrawal, fatigue, and sleep disturbances. Accordingly, chronic inflammatory disorders, such as the inflammatory autoimmune disease multiple sclerosis (MS), have been associated to higher risk of MDD, in comparison with overall population. Importantly, in both MS patients and in its experimental mouse model, Experimental Autoimmune Encephalomyelitis (EAE), the notion that depressive symptoms are reactive epiphenomenon to the MS pathology has been recently challenged by the evidence of their early manifestation, even before the onset of the disease. Furthermore, in association to such mood disturbance, inflammatory-dependent synaptic dysfunctions in several areas of MS/EAE brain have been observed independently of brain lesions and demyelination. This evidence suggests that a fine interplay between the immune and nervous systems can have a huge impact on several neurological functions, including depressive symptoms, in different pathological conditions. The aim of the present review is to shed light on common traits between MDD and MS, by looking at inflammatory-dependent synaptic alterations associated with depression in both diseases.

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“…Some authors also draw attention to the fact that patients with multiple sclerosis who coexist with depressive disorders exhibit cognitive impairment, a higher degree of disability, and respond less well to the treatment of the underlying disease [1]. In addition, Tauil et al [23] showed that patients with longer disease duration are more likely to experience depression.…”

Section: Depressive Disordersmentioning

confidence: 99%

Psychiatric Disorders in the Course of Multiple Sclerosis

Zając¹,

Główczyński²,

Badura-Brzoza³

2020

Wiad Lek

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Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system of a chronic nature, most often with periods of exacerbation and remission, mainly affecting people between 20-40 years of age, with a slight prevalence of women. The aim of the study was to collect and analyze materials published in the literature regarding the prevalence and co-occurrence of mental disorders in patients with multiple sclerosis. Current reports show that as many as 75% of patients with this chronic disease experience various mental disorders, and the incidence of mental diseases - including mood disorders and anxiety disorders - is statistically higher than in the general population. Conclusions: Depending on the literature, depressive symptoms appear in 6.94% -70.1% of patients with MS. Diagnosis of anxiety disorders affects 11.1% of patients, while bipolar disorder affects up to 16.2%. Co-occurrence of MS with schizophrenia is estimated at 1.28%. The incidence of other psychoses is 2-4% in patients with MS. Only in the case of schizophrenia, men with MS are more likely to develop it, while other psychiatric disorders are more common among women. Co-occurrence of mental disorders in the course of multiple sclerosis adversely affects the treatment process and the functioning of patients and their families.

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Suicidal ideation, anxiety, and depression in patients with multiple sclerosis

Abstract: A high prevalence of depression and anxiety, and a higher rate of suicidal ideation were identified in MS patients compared to the general population. The presence of depressive symptoms appeared to have a direct influence on the risk of suicide.

Cited by 42 publications

References 18 publications

Interpersonal Risk Factors for Suicide in Cocaine Dependence: Association with Self‐Esteem, Personality Traits, and Childhood Abuse

Interpersonal Risk Factors for Suicide in Cocaine Dependence: Association with Self‐Esteem, Personality Traits, and Childhood Abuse

Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis

Psychiatric Disorders in the Course of Multiple Sclerosis

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