Amitriptyline and intraoral devices for migraine prevention: a randomized comparative trial

Bruno, Marco; Krymchantowski, Abouch Valenty

doi:10.1590/0004-282x20180023

Cited by 8 publications

(28 citation statements)

References 21 publications

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“…[18] Disocclusion or any high contact during occlusion creates an imbalance in the relaxation of the masticatory muscles considering their role in maximal intercuspation and in centric relation. [19] The relieve of the high contacts to attain an occlusal equilibration helps in relieving the symptoms the TMD's. [7,20] In addition, intra-oral splints either alone or in combination with other approaches are often used to reduce pain and improve function in patients with myofascial pain.…”

Section: Discussionmentioning

confidence: 99%

Clinical assessment of Nociceptive trigeminal inhibition tension suppression system (NTI-tss) appliance for Temporomandibular joint disorder associated with headache- A Case report

Ravi¹,

Sowmya²,

Roy³

2021

IJCRD

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Temporomandibular disorder and bruxism may cause individuals to experience extreme pain in the region of jaw and head. The associated musculature and the joint are placed at a strained position which manifests as unbearable pain. This pain may radiate to face, neck and some may even develop migraine, all of which can have painful and a debilitating effect on an individual. This paper describes the case where a patient who was suffering from TMJ pain from 8 years using multiple occlusal splints over the course of years but showed no signs of relief thus, impairing the quality of life. TMD's constitute a group of disease with overlapping similar sign and symptoms. In this case, the patient was diagnosed and treated with the NTI-tSS appliance, with a 6 month follow up showing almost complete resolution of the symptoms enhancing the quality of life.

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Section: Discussionmentioning

confidence: 99%

Clinical assessment of Nociceptive trigeminal inhibition tension suppression system (NTI-tss) appliance for Temporomandibular joint disorder associated with headache- A Case report

Ravi¹,

Sowmya²,

Roy³

2021

IJCRD

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“…Research on the use of TCAs for chronic migraine [39], insomnia [40,41], alcohol use disorder [42,43], and neuropathic corneal pain has been conducted with indications of therapeutic efficacy, though adverse effects remain a concern.…”

Section: Tricyclic Antidepressantsmentioning

confidence: 99%

Novel Pharmacological Approaches to the Treatment of Depression

Elias

Zhang

Manners

2022

Life

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Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-based antidepressants were the first drugs developed to treat major depressive disorder. More recently, ketamine and other analogues were introduced as fast-acting antidepressants. Unfortunately, currently available therapeutics are inadequate; lack of efficacy, adverse effects, and risks leave patients with limited treatment options. Efforts are now focused on understanding the etiology of depression and identifying novel targets for pharmacological treatment. In this review, we discuss promising novel pharmacological targets for the treatment of major depressive disorder. Targeting receptors including N-methyl-D-aspartate receptors, peroxisome proliferator-activated receptors, G-protein-coupled receptor 39, metabotropic glutamate receptors, galanin and opioid receptors has potential antidepressant effects. Compounds targeting biological processes: inflammation, the hypothalamic-pituitary-adrenal axis, the cholesterol biosynthesis pathway, and gut microbiota have also shown therapeutic potential. Additionally, natural products including plants, herbs, and fatty acids improved depressive symptoms and behaviors. In this review, a brief history of clinically available antidepressants will be provided, with a primary focus on novel pharmaceutical approaches with promising antidepressant effects in preclinical and clinical studies.

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“…To date, most studies show no additional benefit in comparing ACs with FPs. Furthermore, headache studies have shown that there was minimal effect in improvement of migraine headaches using ACs when compared to low dose tricyclic antidepressant medication (38). There have been both one MAUDE database report and anecdotal evidence to indicate that these appliances even worn just at night can cause occlusal changes with resulting anterior open bite.…”

Section: Anterior Only Contacting Oas (Acs)mentioning

confidence: 99%

Intraoral appliances for temporomandibular disorders: what we know and what we need to know

Menchel¹,

Greene²,

Huff³

2021

Front Oral Maxillofac Med

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Oral appliances (OAs) have been a part of the clinical protocols used by many dentists over the past 100 years for treating patients with temporomandibular disorders (TMDs). However, in a field filled with many conceptual and clinical controversies, these devices remain near the top of the list of controversial topics. There are multiple designs proposed for making OAs, and there are disagreements about when and how they should be utilized. There are also theoretical arguments about what they are intended to do therapeutically. However, the most significant point of contention is whether OAs should be regarded as a first phase of TMD treatment, to be followed by a second phase of major dental procedures to realign the condylar position as well as the occlusal relationships. Alternatively, within the past 50 years many researchers have established an evidence base supporting a more conservative application of OAs in which they are an orthotic modality intended to produce relief from pain and improvement in jaw function-after which they may be removed or used to respond to symptomatic flareups. This paper discusses what we currently know, and what more we need to know, in order to deal with this confusing topic in the best interest of managing various categories of TMD patients. It concludes with a proposal for future research directions which may help to clarify some of these issues.

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Amitriptyline and intraoral devices for migraine prevention: a randomized comparative trial

Abstract: Amitriptyline proved superior to the NTI-tss and the non-occlusal splint. Despite its approval by the United States Food and Drug Administration, the NTI-tss was not superior to a sham device.

Cited by 8 publications

References 21 publications

Clinical assessment of Nociceptive trigeminal inhibition tension suppression system (NTI-tss) appliance for Temporomandibular joint disorder associated with headache- A Case report

Clinical assessment of Nociceptive trigeminal inhibition tension suppression system (NTI-tss) appliance for Temporomandibular joint disorder associated with headache- A Case report

Novel Pharmacological Approaches to the Treatment of Depression

Intraoral appliances for temporomandibular disorders: what we know and what we need to know

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