Migraine improvement correlates with posterior cingulate cortical thickness reduction

Amaral, Vanise C G; Tukamoto, Gustavo; Kubo, Tadeu Takao Almodovar; Luiz, Ronir Raggio; Gasparetto, Emerson L.; Vincent, Maurice

doi:10.1590/0004-282x20180004

Cited by 9 publications

(6 citation statements)

References 36 publications

(32 reference statements)

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“…Prior literature on regional morphological alterations in brain gray matter in chronic neuropathic pain subjects have revealed widespread cortical thickness abnormalities. In comparison to healthy controls, subjects with orofacial chronic neuropathic pain showed thicker postcentral gyrus, thinner insular cortex, and thinner cuneus cortex ( Amaral et al, 2018 , Hubbard et al, 2014 , Maleki et al, 2015 , Moayedi et al, 2011 , Parise et al, 2014 , Wang et al, 2017a , Wang et al, 2017b , Yang et al, 2017 ). Our current study adds to the clinical importance of these observations by showing insular cortical thickness is predictive of individual-level 1 year response to surgical interventions for orofacial chronic neuropathic pain like trigeminal neuralgia.…”

Section: Discussionmentioning

confidence: 99%

Regional brain morphology predicts pain relief in trigeminal neuralgia

Hung

Noorani

Zhang

et al. 2021

NeuroImage: Clinical

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Highlights Regional brain gray matter morphology robustly predict TN radiosurgery response. Surface area ML model was 96.7% accurate, 100.0% sensitive, and 89.1% specific. Top predictor for surface area model was contralateral superior frontal gyrus. Cortical thickness ML model was 90.5% accurate, 93.5% sensitive, and 83.7% specific. Top predictor for cortical thickness model was contralateral isthmus cingulate gyrus.

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Section: Discussionmentioning

confidence: 99%

Regional brain morphology predicts pain relief in trigeminal neuralgia

Hung

Noorani

Zhang

et al. 2021

NeuroImage: Clinical

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“…A prior migraine study demonstrated that migraine improvement (i.e. reduced time with headache) was associated with cortical thickness changes in the left posterior cingulate [ 50 ]. The putamen participates in sensory-discriminative aspects of pain processing including the determination of pain sensitivity [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

“…A prior migraine study demonstrated that migraine improvement (i.e. reduced time with headache) was associated with cortical thickness changes in the left posterior cingulate [50].…”

Section: Pain-induced Activationsmentioning

confidence: 99%

Longitudinal changes in functional connectivity and pain-induced brain activations in patients with migraine: a functional MRI study pre- and post- treatment with Erenumab

et al. 2022

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Background Migraine involves central and peripheral nervous system mechanisms. Erenumab, an anti-calcitonin gene-related peptide (CGRP) receptor monoclonal antibody with little central nervous system penetrance, is effective for migraine prevention. The objective of this study was to determine if response to erenumab is associated with alterations in brain functional connectivity and pain-induced brain activations. Methods Adults with 6–25 migraine days per month during a 4-week headache diary run-in phase underwent pre-treatment brain functional MRI (fMRI) that included resting-state functional connectivity and BOLD measurements in response to moderately painful heat stimulation to the forearm. This was followed by two treatments with 140 mg erenumab, at baseline and 4 weeks later. Post-treatment fMRI was performed 2 weeks and 8 weeks following the first erenumab treatment. A longitudinal Sandwich estimator analysis was used to identify pre- to post-treatment changes in resting-state functional connectivity and brain activations in response to thermal pain. fMRI findings were compared between erenumab treatment-responders vs. erenumab non-responders. Results Pre- and post-treatment longitudinal imaging data were available from 32 participants. Average age was 40.3 (+/− 13) years and 29 were female. Pre-treatment average migraine day frequency was 13.8 (+/− 4.7) / 28 days and average headache day frequency was 15.8 (+/− 4.4) / 28 days. Eighteen of 32 (56%) were erenumab responders. Compared to erenumab non-responders, erenumab responders had post-treatment differences in 1) network functional connectivity amongst pain-processing regions, including higher global efficiency, clustering coefficient, node degree, regional efficiency, and modularity, 2) region-to-region functional connectivity between several regions including temporal pole, supramarginal gyrus, and hypothalamus, and 3) pain-induced activations in the middle cingulate, posterior cingulate, and periaqueductal gray matter. Conclusions Reductions in migraine day frequency accompanying erenumab treatment are associated with changes in resting state functional connectivity and central processing of extracranial painful stimuli that differ from erenumab non-responders. Trial registration clinicaltrials.gov (NCT03773562).

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“…In their study population, changes in the left posterior cingulate cortex correlated with headache frequency and intensity. 42 Studies with TTH are quite limited. Chen et al reported no significant difference in gray matter density between TTH patients and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Visual rating of cortical atrophy in migraine and tension-type headache

Yıldırım¹,

Eyigürbüz²,

Şentürk³

et al. 2022

NeuroAsia

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Background: Studies of cortical atrophy in migraine and tension-type headache (TTH) have reported inconsistent results. Some studies have reported decreased cortical thickness or volume, while others have reported thickening in the somatosensory and visual cortices in migraine patients. The same controversy is true with respect to episodic and chronic headaches. This study evaluated and compared cortical atrophy in migraine and TTH as well as in episodic and chronic headache. Methods: The study included 43 (37 female) migraine and 15 (12 female) TTH patients. Demographic, clinical, and brain magnetic resonance imaging (MRI) data were evaluated. 1.5 Tesla MRI brain coronal T2 sequences were reviewed by two neurologists, and atrophy was graded according to a visual rating scale (VRS). Two neurologists jointly evaluated and scored cortical thickness on a Likert scale of 0 to 3 or 4 at the following sites bilaterally: olfactory sulcus, anterior cingulate sulcus, circular insular sulcus, anterior temporal and medial temporal lobes, and posterior cingulate and parieto-occipital sulci. The scores at all sites were then summed into a total atrophy score (TAS) for each subject. Results: There was no significant difference between the migraine and TTH groups regarding demographics, clinical findings, and atrophy scores in any particular region or with respect to the TAS. When we divided our study subjects into episodic and chronic headache groups, there was no significant difference between these groups in terms of demographic and clinical findings or individual and total atrophy scores. Conclusions: These results are in line with previous studies that have reported no differences between migraine and TTH in terms of cortical atrophy.

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Migraine improvement correlates with posterior cingulate cortical thickness reduction

Cited by 9 publications

References 36 publications

Regional brain morphology predicts pain relief in trigeminal neuralgia

Regional brain morphology predicts pain relief in trigeminal neuralgia

Longitudinal changes in functional connectivity and pain-induced brain activations in patients with migraine: a functional MRI study pre- and post- treatment with Erenumab

Visual rating of cortical atrophy in migraine and tension-type headache

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