2015
DOI: 10.1590/0004-282x20140202
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Abstract: Objective: To evaluate the effect of waiting time (WT) to radiotherapy (RT) on overall survival (OS) of glioblastoma (GBM) patients as a reliable prognostic variable in Brazil, a scenario of medical disparities. Method: Retrospective study of 115 GBM patients from two different health-care institutions (one public and one private) in Brazil who underwent post-operative RT. Results: Median WT to RT was 6 weeks (range, 1.3-17.6). The median OS for WT # 6 weeks was 13.5 months (95%CI , 9.1-17.9) and for WT . 6 we… Show more

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Cited by 13 publications
(12 citation statements)
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“…Studies included for Meta-analysis (20) analyzed the relationship between delayed radiotherapy and the prognosis of high-grade glioma based on MGMT promoter methylation status. With the exception of two studies, almost all of them focused on the relationship between WT and OS.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Studies included for Meta-analysis (20) analyzed the relationship between delayed radiotherapy and the prognosis of high-grade glioma based on MGMT promoter methylation status. With the exception of two studies, almost all of them focused on the relationship between WT and OS.…”
Section: Resultsmentioning
confidence: 99%
“…(Figure 3,4).The prognostic factors were adjusted by meta-regression, there is still no clear evidence that the waiting time of radiotherapy has an impact on the prognosis of high-grade glioma patients (Table 3). 14,20,25,30 1.000 0.976-1.025 0.934 a.Adeberg [21] reported HR of KPS>70% and it was converted according to the method proposed by Tierney [34] .…”
Section: Resultsmentioning
confidence: 99%
“…Regarding the study about RT delaying, glioblastoma, lung cancer, and breast cancer had been thoroughly studied; however, the results were different. Most of the studies [14] , [15] , [16] , [17] , [18] found no statistically significant relationship between survival and the time from surgery to the initiation of RT. Do et al [18] used multivariate analysis to assess the effect of radiotherapy delay on survival in a retrospective study of 182 patients with high-grade glioma and found no significant effect of delaying postoperative RT on OS.…”
Section: Discussionmentioning
confidence: 97%
“…Although some authors found that RT delay has negative effects on OS 25,27 this topic remains controversial. In turn, Loureiro et al 28 assessed the time elapsed from surgery to onset of RT at one public and one private healthcare service in Brazil and also failed to find any difference in OS in association with delayed RT (RR = 1.2; 95%CI = 0.8 -1.8; p = 0.470).…”
Section: Influence Of Radiotherapy Delay On Survivalmentioning
confidence: 99%
“…While difficulty in meeting the demand is encountered in developed countries, it is much more frequent in developing countries, especially in the public healthcare setting 28 . In Brazil, the situation is especially worrisome, as the increasing demand for RT created an inefficient system; thus, only 65.9% of the patients needing RT actually receive it, having to wait a median interval of almost four months, independent of the type of cancer 28 . Our service represents a classic example of these problems: onset of RT was delayed in 74% of the patients analyzed in the present study: the median interval from surgery to onset of RT was eight months.…”
Section: Influence Of Radiotherapy Delay On Survivalmentioning
confidence: 99%