Overlapping MRI findings in progressive supranuclear palsy ? corticobasal syndrome

Prezzi, Eduardo Della Valle; Vasconcellos, Luiz Felipe Rocha; Marussi, Victor Hugo Rocha

doi:10.1590/0004-282x20140065

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…The CBS-AD group was associated with a posterior pattern of gray matter imaging loss, involving parietal, posterior temporal and occipital lobes. 33 , 34 …”

Section: Imaging and Biomarkersmentioning

confidence: 99%

Corticobasal syndrome: A diagnostic conundrum

Parmera

Rodriguez

Neto

et al. 2016

Dement. neuropsychol.

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Corticobasal syndrome (CBS) is an atypical parkinsonian syndrome of great interest to movement disorder specialists and behavioral neurologists. Although originally considered a primary motor disorder, it is now also recognized as a cognitive disorder, usually presenting cognitive deficits before the onset of motor symptoms. The term CBS denotes the clinical phenotype and is associated with a heterogeneous spectrum of pathologies. Given that disease-modifying agents are targeting the pathologic process, new diagnostic methods and biomarkers are being developed to predict the underlying pathology. The heterogeneity of this syndrome in terms of clinical, radiological, neuropsychological and pathological aspects poses the main challenge for evaluation.

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“…The CBS-AD group was associated with a posterior pattern of gray matter imaging loss, involving parietal, posterior temporal and occipital lobes. 33 , 34 …”

Section: Imaging and Biomarkersmentioning

confidence: 99%

Corticobasal syndrome: A diagnostic conundrum

Parmera

Rodriguez

Neto

et al. 2016

Dement. neuropsychol.

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An autopsy case of type A FTLD‐TDP with a GRN mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently

Tomenaga,

Minatani,

Namba

et al. 2024

Neuropathology

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A 68‐year‐old woman presented with difficulty finding words and writing characters. Neurological examination led to clinical diagnosis at onset of the logopenic variant of primary progressive aphasia accompanied with ideomotor apraxia, visuospatial agnosia on the right, and Gerstmann syndrome. Bradykinesia and rigidity on the right with shuffling gait developed after one year. Treatment with L‐dopa had no effect. The patient was diagnosed with corticobasal syndrome (CBS). Brain magnetic resonance imaging revealed diffuse cortical atrophy dominantly on the left, especially in the temporal, parietal, and occipital lobes. Positron emission tomography did not reveal any significant accumulation of amyloid β or tau protein. She died five years later. Neuropathological examination revealed diffuse cortical atrophy with severe neuronal loss and fibrous gliosis in the cortex. Neuronal cytoplasmic inclusions, short dystrophic neurites, and, most notably, neuronal intranuclear inclusions, all immunoreactive for phosphorylated TDP‐43, were observed. Western blotting revealed a full length and fragments of phosphorylated TDP‐43 at 45 and 23 kDa, respectively, confirming the pathological diagnosis of type A FTLD‐TDP. Whole exome sequencing revealed a pathogenic mutation in GRN (c.87dupC). FTLD‐TDP should be included in the differential diagnosis of CBS.

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Neuroimaging Research on Dementia in Brazil in the Last Decade: Scientometric Analysis, Challenges, and Peculiarities

2021

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The last years have evinced a remarkable growth in neuroimaging studies around the world. All these studies have contributed to a better understanding of the cerebral outcomes of dementia, even in the earliest phases. In low- and middle-income countries, studies involving structural and functional neuroimaging are challenging due to low investments and heterogeneous populations. Outstanding the importance of diagnosing mild cognitive impairment and dementia, the purpose of this paper is to offer an overview of neuroimaging dementia research in Brazil. The review includes a brief scientometric analysis of quantitative information about the development of this field over the past 10 years. Besides, discusses some peculiarities and challenges that have limited neuroimaging dementia research in this big and heterogeneous country of Latin America. We systematically reviewed existing neuroimaging literature with Brazilian authors that presented outcomes related to a dementia syndrome, published from 2010 to 2020. Briefly, the main neuroimaging methods used were morphometrics, followed by fMRI, and DTI. The major diseases analyzed were Alzheimer's disease, mild cognitive impairment, and vascular dementia, respectively. Moreover, research activity in Brazil has been restricted almost entirely to a few centers in the Southeast region, and funding could be the main driver for publications. There was relative stability concerning the number of publications per year, the citation impact has historically been below the world average, and the author's gender inequalities are not relevant in this specific field. Neuroimaging research in Brazil is far from being developed and widespread across the country. Fortunately, increasingly collaborations with foreign partnerships contribute to the impact of Brazil's domestic research. Although the challenges, neuroimaging researches performed in the native population regarding regional peculiarities and adversities are of pivotal importance.

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Overlapping MRI findings in progressive supranuclear palsy ? corticobasal syndrome

Cited by 3 publications

References 3 publications

Corticobasal syndrome: A diagnostic conundrum

Corticobasal syndrome: A diagnostic conundrum

An autopsy case of type A FTLD‐TDP with a GRN mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently

Neuroimaging Research on Dementia in Brazil in the Last Decade: Scientometric Analysis, Challenges, and Peculiarities

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