The prevalence of the metabolic syndrome increases through the           quartiles of thyroid stimulating hormone in a population-based sample of euthyroid           subjects

Shinkov, Alexander; Borissovа, Anna-Maria; Кovatcheva, Roussanka; Atanassova, Iliana; Vlahov, Jordan; Dakovska, Lilia

doi:10.1590/0004-2730000003538

Cited by 25 publications

(26 citation statements)

References 28 publications

(29 reference statements)

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“…The significant positive correlations between CRP and IL-6 in both OB groups as well as in the hypothyroid patients with a normal BMI (Group C) corresponded to data of other authors reporting that thyroid deficiency and visceral obesity are independently associated with increased CRP and IL-6 as markers of low-grade chronic inflammation of adipose tissue [9][10][11]. Some found that euthyroid subjects with TSH in upper normal range (2.5-4.5 mU/l) and normal FT3 and FT4 had increased BMI and significantly higher prevalence of metabolic syndrome [12,13]. In this respect, thyroid hormone deficiency seems to be a possible pathogenetic factor, which aggravates the metabolic disturbances.…”

Section: Discussionsupporting

confidence: 83%

Role of Thyroid Deficiency on Adiponectin, Leptin, and Metabolic Status in Visceral Obesity: A Cross-Sectional Study

et al. 2017

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Hypothyroidism results in disturbances of metabolism influencing many regulatory systems and active molecules as adipocytokines. Objective of the study was to investigate leptin and adiponectin in patients with visceral obesity and hypothyroidism in relation to metabolic status, insulin resistance and systemic inflammation. A total of 118 patients (59 hypothyroid and 59 euthyroid) were enrolled divided into four age-matched groups according to body wеight (BMI) and thyroid function. Laboratory panel includes TSH, FT4, FT3 (CMIA), adiponectin and leptin (ELISA), IL- 6 (ECLIA), CRP, insulin, glucose, apolipoprotein B and lipoprotein (a) - Lp(a). Hypothyroid patients revealed significant positive correlations of TSH, adiponectin and Lp(a). Their medians of 10.4 mU/l, 12.5 µg/ml and 116.3 mg/l respectively were significantly higher than in euthyroid patients- 1.5 mU/l, 6.26 µg/ml and 32.0 mU/l (p < 0.0001). Leptin in both obese groups was significantly higher than in patients with normal weight. Leptin in hypothyroid patients was lower but not significant to euthyroid ones (9.7 ng/ml vs 13.4 ng/ml respectively, p = 0.16), correlated negatively to TSH and positively to CRP, IL-6, ApoB, Lp(a) and BMI. HOMA-IR and serum insulin at 120 min in OGTT were significantly higher in hypothyroid than in euthyroid patients independent of BMI (p < 0.001). Adiponectin, insulin resistance and chronic inflammation indices in hypothyroid patients correlated positively to TSH, BMI and atherogenic lipoproteins subclasses ApoB/Lp(a). Increased adiponectin in thyroid deficiency could be due to secondary resistance of adiponectin receptors or appeared as a compensatory pathogenetic factor in hypothyroidism.

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Section: Discussionsupporting

confidence: 83%

Role of Thyroid Deficiency on Adiponectin, Leptin, and Metabolic Status in Visceral Obesity: A Cross-Sectional Study

et al. 2017

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“…Several cross‐sectional studies have explored the association between THs or TSH and MetS in euthyroid subjects. Most of these studies only reported the association between TSH within reference range and the prevalence of MetS, which showed that serum TSH levels were positively associated with MetS in different populations . Another three cross‐sectional studies demonstrated that higher FT3 and lower FT4 levels were associated with higher odds ratio of MetS .…”

Section: Discussionmentioning

confidence: 99%

“…To date, only several cross‐sectional studies have evaluated the association between THs or TSH and MetS in euthyroid subjects, and a few studies assessed just MetS components individually rather than the syndrome as a whole . Additionally, only one cohort study evaluated the association between TSH levels and the prevalence and incidence of the MetS in older people (aged 70‐79 years) .…”

Section: Introductionmentioning

confidence: 99%

The association between thyroid function and incidence of metabolic syndrome in euthyroid subjects: Tianjin chronic low‐grade systemic inflammation and health cohort study

Wang

Zhang

et al. 2018

Clinical Endocrinology

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“…Indeed, it may often be recognized as one of the metabolic syndrome features. Also, TSH levels have been associated with increased body fat and BMI, as well as increased cardiovascular risk [35], although the studies are still controversial [36,37]. Within the reference range, it was already acknowledged that TSH levels seem to increase the BMI proportionally [38].…”

Section: Discussionmentioning

confidence: 99%

Association between Thyroid-Stimulating Hormone Levels and Non-Alcoholic Fatty Liver Disease Is Not Independent from Metabolic Syndrome Criteria

Janovsky¹,

Cesena

Valente

et al. 2018

Eur Thyroid J

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Introduction: Thyroid hormones are involved in the regulation of body composition, lipid metabolism, and insulin resistance. Thus, it is possible that they might play a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the role of thyroid function on NAFLD is not well defined. In this study, we evaluated the relationship between thyroid-stimulating hormone (TSH) levels, within the reference range, and presence of NAFLD in asymptomatic individuals. Study Design: We included all individuals evaluated at a preventive clinic of the Hospital Israelita Albert Einstein, between 2014 and 2015. The prevalence of NAFLD (analyzed by abdominal ultrasound), according to TSH quartiles, within the reference range, was determined. The association between TSH quartiles and NAFLD was analyzed by logistic regression adjusted for possible confounders. Results: We evaluated 10,539 individuals (73% male, age 43.4 ± 9.4 years). The prevalence of NAFLD was 34, 38, 38, and 39% in the first to the fourth TSH quartiles (0.46–1.44, 1.45–1.97, 1.98–2.68, and 2.69–4.68 mUI/L, respectively, p for trend < 0.001). At univariate analysis, higher TSH levels were associated with the diagnosis of NAFLD. When data were adjusted for the metabolic syndrome characteristics (waist circumference, HDL-cholesterol and triglycerides levels, presence of diabetes, and systemic arterial hypertension), the association was no longer significant. Conclusions: Although the TSH variability within the reference range is associated with NAFLD in univariable models, once adjusted for metabolic syndrome factors no significant association is noted.

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The prevalence of the metabolic syndrome increases through the quartiles of thyroid stimulating hormone in a population-based sample of euthyroid subjects

Cited by 25 publications

References 28 publications

Role of Thyroid Deficiency on Adiponectin, Leptin, and Metabolic Status in Visceral Obesity: A Cross-Sectional Study

Role of Thyroid Deficiency on Adiponectin, Leptin, and Metabolic Status in Visceral Obesity: A Cross-Sectional Study

The association between thyroid function and incidence of metabolic syndrome in euthyroid subjects: Tianjin chronic low‐grade systemic inflammation and health cohort study

Association between Thyroid-Stimulating Hormone Levels and Non-Alcoholic Fatty Liver Disease Is Not Independent from Metabolic Syndrome Criteria

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