2014
DOI: 10.1590/0004-2730000003295
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Abstract: Objective: The present study aimed to examine the effects of thyroid hormone (TH), more precisely triiodothyronine (T3), on the modulation of TH receptor alpha (TRα) mRNA expression and the involvement of the phosphatidyl inositol 3 kinase (PI3K) signaling pathway in adipocytes, 3T3-L1, cell culture. Materials and methods: It was examined the involvement of PI3K pathway in mediating T3 effects by treating 3T3-L1 adipocytes with physiological (P = 10nM) or supraphysiological (SI = 100 nM) T3 doses during one ho… Show more

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Cited by 7 publications
(7 citation statements)
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“…The 3T3‐L1 cell line was used as described previously by de Oliveira et al ( and Oliveira et al (, , ). After confluence, the differentiation process was initiated by culturing the cells for 3 days in DMEM containing 10% FBS, 0.5 mM IBMX, 1 mM dexamethasone, and 1 mg/mL insulin.…”
Section: Methodsmentioning
confidence: 99%
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“…The 3T3‐L1 cell line was used as described previously by de Oliveira et al ( and Oliveira et al (, , ). After confluence, the differentiation process was initiated by culturing the cells for 3 days in DMEM containing 10% FBS, 0.5 mM IBMX, 1 mM dexamethasone, and 1 mg/mL insulin.…”
Section: Methodsmentioning
confidence: 99%
“…Cell differentiation was evaluated by the presence of lipid droplets stained with Oil Red O, as described previously (de Oliveira et al, 2013;Oliveira et al, 2013Oliveira et al, , 2014Oliveira et al, , 2015. After fixation with 37% formaldehyde for 30 min at room temperature (RT), cells were stained for 2 h at 37 C temperature with 5% Oil Red O.…”
Section: Oil Red O Stainingmentioning
confidence: 99%
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“…Cancer is the number of over than 100 different types of diseases characterized by uncontrolled growth of abnormal cells with invasive potential. It is entailed by various conditions and has several factors that can either start it or promote it [1]. It is the leading cause of death in economically developed countries and the second leading cause in developing countries [2].…”
Section: Introductionmentioning
confidence: 99%
“…According to estimatives, there were 14.1 million new cancer cases and a total of 8.2 million deaths from cancer worldwide in 2012 [1]. Cancer is currently the second leading cause of death in the United States, and is expected to surpass heart diseases as the leading cause of death.…”
Section: Introductionmentioning
confidence: 99%