2014
DOI: 10.1590/0004-2730000003051
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Abstract: Polycystic ovary syndrome (PCOS) is a common condition in women at reproductive age associated with reproductive and metabolic dysfunction. Proposed diagnosed criteria for PCOS include two out of three features: androgen excess, menstrual irregularity, and polycystic ovary appearance on ultrasound (PCO), after other causes of hyperandrogenism and dysovulation are excluded. Based on these diagnostic criteria, the most common phenotypes are the "classic PCOS" -hyperandrogenism and oligomenorrhea, with or without… Show more

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Cited by 82 publications
(66 citation statements)
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“…In fact, abdominal adiposity, often present even in nonobese PCOS women, is a hallmark of insulin resistance. Thus, clinical markers of abdominal adiposity should be searched in each PCOS woman as a screening for higher metabolic risk and for prevention of metabolic comorbidities (Spritzer 2014). In this sense, we have previously shown that measuring waist circumference (WC), an easy procedure to estimate body fat R224 P M Spritzer and others distribution, in obese PCOS and healthy control women with the same BMI is strongly correlated with truncal fat mass estimated by dual-energy X-ray absorptiometry ( Fig.…”
Section: Metabolic Repercussions Of Adipose Tissue Dysfunction In Pcosmentioning
confidence: 96%
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“…In fact, abdominal adiposity, often present even in nonobese PCOS women, is a hallmark of insulin resistance. Thus, clinical markers of abdominal adiposity should be searched in each PCOS woman as a screening for higher metabolic risk and for prevention of metabolic comorbidities (Spritzer 2014). In this sense, we have previously shown that measuring waist circumference (WC), an easy procedure to estimate body fat R224 P M Spritzer and others distribution, in obese PCOS and healthy control women with the same BMI is strongly correlated with truncal fat mass estimated by dual-energy X-ray absorptiometry ( Fig.…”
Section: Metabolic Repercussions Of Adipose Tissue Dysfunction In Pcosmentioning
confidence: 96%
“…Frequently, however, it will be necessary to add an insulin-sensitizing drug (Spritzer 2014). Metformin has been shown to ameliorate cardiometabolic profile by improving insulin sensitivity, lowering blood glucose and androgen levels, possibly through its effects on body weight (Nieuwenhuis-Ruifrok et al 2009).…”
Section: Metabolic Repercussions Of Adipose Tissue Dysfunction In Pcosmentioning
confidence: 99%
“…However, while being a common trait, insulin resistance is not a universal feature of PCOS 19,24 . In addition, the focus of treatment should be their clinical consequences instead of the insulin resistance per se, such as metabolic syndrome, abdominal adiposity (waist circumference higher than 88 cm) as well as impaired fasting glucose (IFG, fasting glucose between 100 and 125 mg/dL), impaired glucose tolerance (IGT, 2 h post-glucose between 140 and 199 mg/dL) and T2 diabetes (fasting glucose equal or higher than 126 and/or 2 h post-glucose equal or higher than 200 mg/dL) 2,24,25 . Lifestyle change is the first-line non-pharmacological therapy to lessen cardiovascular and metabolic risks, mainly in overweight or obese PCOS women, and should combine behavioral (reduction of psychosocial stressors), dietary, and exercise management [26][27][28] .…”
Section: Metabolic Disturbances and Cardiovascular Risk Factors In Womentioning
confidence: 99%
“…In essence, PCOS is characterized by androgen excess and chronic anovulation. However, the clinical presentation is heterogeneous among patients and may change in the same women along the years [2][3][4] . Most common signs and symptoms include hirsutism, irregular menstrual cycles and infertility.…”
mentioning
confidence: 99%
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