Breast cancer metastasis to the pituitary gland

Magalhães, J. F. F.; Bacchin, Renata Prota; Costa, Priscila Scatena; Alves, Giovanni; Filho, Fadlo Fraige; Stella, Lenira Cristina

doi:10.1590/0004-2730000002950

Cited by 12 publications

(2 citation statements)

References 17 publications

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“…The frequencies of primary sites are summarized in Fig. 1 (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 10...…”

Section: Resultsmentioning

confidence: 99%

Pituitary metastasis: a rare condition

Javanbakht

D’Apuzzo

Badie

et al. 2018

Endocrine Connections

129

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Tumor metastasis to the pituitary gland is a rare, not well-documented and life-threatening condition associated with a shortened life span. A better understanding of its clinical manifestations could lead to earlier diagnosis, appropriate therapy and potentially improving quality of life. Therefore, we retrospectively studied the charts of patients with pituitary metastases who were treated at the City of Hope National Medical Center (Duarte, CA) from 1984 to 2018. We reviewed and analyzed tumor origin, primary pituitary clinical manifestation, duration between primary tumor diagnosis and pituitary metastasis, type of treatment and patient survival. A total of 11 patients were identified with a mean age of 59.2 years and median survival following the diagnosis of metastasis of 10 months. Breast cancer and lymphoma were the most common primary origins in these cases, and diabetes insipidus and panhypopituitarism were the most common clinical manifestations of their metastasis. We also compared our results with reports in the literature published between 1957 and 2018. A total 289 patients with pituitary metastasis have been reported in the literature. Breast cancer was the most frequent primary origin of the metastasis, and visual symptoms were the most common primary manifestation. The posterior part of the pituitary is more susceptible than the anterior to metastasis. Pituitary metastasis may occur as a consequence of successful primary tumor treatment prolonging the chance of seeding. Future studies are needed to determine the molecular mechanism of metastasis to the pituitary.

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Section: Resultsmentioning

confidence: 99%

Pituitary metastasis: a rare condition

Javanbakht

D’Apuzzo

Badie

et al. 2018

Endocrine Connections

129

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“…At least in part the reason is that these two types of malignancies are most commonly encountered in clinical practice. Less often described are metastasis of renal cell carcinoma, gastrointestinal tumours, lymphomas, leukemias, thyroid carcinomas, myeloma, hepatocellular carcinoma and rhabdomyosarcoma (Table 1) [1,2,[7][8][9][10][11][12][13][14][15][16][17][18][19]. When confirming the metastasis in the pituitary, there are frequently metastases present at several other locations, most often in bones.…”

Section: Discussionmentioning

confidence: 99%

Hypophyseal metastases: A report of three cases and literature review

Ravnik

Ŝmigoc

Bunc

et al. 2016

Neurologia i Neurochirurgia Polska

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Metastatic tumours to the pituitary gland are rare. The most frequent are metastases from breast and lung. We describe three patients with metastatic tumours: (I) a 54-year-old patient with metastatic renal clear-cell carcinoma and consequent disturbances in visual acuity, cranial nerve paresis and panhypopituitarism, (II) a 60-year-old patient with a diffuse large B-cell lymphoma with panhypopituitarism and diabetes insipidus and (III) a 57-year-old patient with metastasis of breast cancer and panhypopituitarism, visual impairment and cranial nerve paresis. A transnasal endoscopic biopsy and resection of the tumour was performed in all patients, followed by the oncological treatment. Despite the rarity of the disease, it is important to suspect a metastatic pituitary tumour especially in the case of diabetes insipidus, ophthalmoplegia, rapid course of the disease and headaches. In 20-30% of patients, a metastasis to the pituitary is the first manifestation of a tumour of unknown origin. Surgical and adjuvant therapy may improve the quality of life. The survival is not affected, however, and the prognosis of the disease is usually poor.

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Imaging of metastases from breast cancer to uncommon sites: a pictorial review

et al. 2016

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There are three types of breast cancer recurrence which can occur after initial treatment: local, regional, and distant. Distant metastases are more frequent than local and regional recurrences. It usually occurs several years after the primary breast cancer, although it is sometimes diagnosed at the same time as the primary breast cancer. Although the common distant metastases are bone, lung and liver, breast cancer has the potential to metastasize to almost any region of the body. Early detection and treatment of distant metastases improves the prognosis, therefore radiologists and clinicians should recognize the possibility of metastasis from breast cancer and grasp the imaging characteristics. In this report, we demonstrate the imaging characteristics of metastases from breast cancer to uncommon sites.

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Breast cancer metastasis to the pituitary gland

Cited by 12 publications

References 17 publications

Pituitary metastasis: a rare condition

Pituitary metastasis: a rare condition

Hypophyseal metastases: A report of three cases and literature review

Imaging of metastases from breast cancer to uncommon sites: a pictorial review

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